Ultrashort relativistic electron bunches and spatio-temporal radiation biology

Y. A. Gauduel; J. Faure; V. Malka

doi:10.1117/12.793733

3 September 2008 Ultrashort relativistic electron bunches and spatio-temporal radiation biology

Y. A. Gauduel, J. Faure, V. Malka

Proceedings Volume 7080, Penetrating Radiation Systems and Applications IX; 708002 (2008) https://doi.org/10.1117/12.793733
Event: Optical Engineering + Applications, 2008, San Diego, California, United States

Abstract

The intensive developments of terawatt Ti:Sa lasers permit to extend laser-plasma interactions into the relativistic regime, providing very-short electron or proton bunches. Experimental researches developed at the interface of laser physics and radiation biology, using the combination of sub-picosecond electron beams in the energy range 2-15 MeV with femtosecond near-IR optical pulses might conjecture the real-time investigation of penetrating radiation effects. A perfect synchronization between the particle beam (pump) and optical beam at 820 nm (probe) allows subpicosecond time resolution. This emerging domain involves high-energy radiation femtochemistry (HERF) for which the early spatial energy deposition is decisive for the prediction of cellular and tissular radiation damages. With vacuum-focused intensities of 2.7 x 10¹⁹ W cm^-2 and a high energy electron total charge of 2.5 nC, radiation events have been investigated in the temporal range 10^-13 - 10^-10s. The early radiation effects of secondary electron on biomolecular sensors may be investigated inside sub-micrometric ionisation, considering the radial direction of Gaussian electron bunches. It is shown that short range electron-biosensor interactions lower than 10 A take place in nascent track structures triggered by penetrating radiation bunches. The very high dose delivery 10¹³ Gy s^-1 performed with laser plasma accelerator may challenge our understanding of nanodosimetry on the time scale of molecular target motions. High-quality ultrashort penetrating radiation beams open promising opportunities for the development of spatio-temporal radiation biology, a crucial domain of cancer therapy, and would favor novating applications in nanomedicine such as highly-selective shortrange pro-drug activation.

Citation Download Citation

Y. A. Gauduel, J. Faure, and V. Malka "Ultrashort relativistic electron bunches and spatio-temporal radiation biology", Proc. SPIE 7080, Penetrating Radiation Systems and Applications IX, 708002 (3 September 2008); https://doi.org/10.1117/12.793733

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