Novel optical sensors for detection of toxins, viruses, and bacteria

Gregory D. Emmerson; Ian J. G. Sparrow; Devaki Bhatta; Jean E. SohnaSohna

doi:10.1117/12.800324

2 October 2008 Novel optical sensors for detection of toxins, viruses and bacteria

Gregory D. Emmerson, Ian J. G. Sparrow, Devaki Bhatta, Jean E. SohnaSohna

Proceedings Volume 7116, Optically Based Biological and Chemical Detection for Defence IV; 711603 (2008) https://doi.org/10.1117/12.800324
Event: SPIE Security + Defence, 2008, Cardiff, Wales, United Kingdom

Abstract

A novel optical sensor system for rapid, sensitive and robust biological detection is presented. Sensor elements based on integrated optical circuits confine all optical signals into a planar format, resulting in a small, low-cost and mechanically stable refractive index sensor, without any external bulk optics. Consequently, the sensor elements are able to operate in real-world environments, resilient to vibration and temperature changes, whilst maintaining refractive index resolution of 10-6. Oxide surfaces on the sensor are ideal for protein attachment and have a long lifetime in buffer solutions (>100hrs). Real-time, label-free detection of biological agents has been demonstrated using antibodies attached to the sensor surface. The sensor design results in a large penetration depth of the sensing light, up to 1μm into the sample liquid, conferring the ability to detect various classes of biological targets, spanning toxins, viruses and bacteria. Each sensing element utilizes parallel multiple wavelength data to provide additional information at the point of measurement, resulting in on-chip temperature and strain referencing, focused towards increased accuracy and reduction of false alarms. The large size range of biological detection, coupled with the long lifetime of the sensors makes the system ideally suited to applications ranging from medical diagnostics to confirmatory detectors for homeland security

Citation Download Citation

Gregory D. Emmerson, Ian J. G. Sparrow, Devaki Bhatta, and Jean E. SohnaSohna "Novel optical sensors for detection of toxins, viruses and bacteria", Proc. SPIE 7116, Optically Based Biological and Chemical Detection for Defence IV, 711603 (2 October 2008); https://doi.org/10.1117/12.800324

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