Implementation of an effective KL domain penalized weighted least-squares sinogram restoration for low-dose CT colonography

Yi Fan; Jing Wang; Hongbing Lu; Zhengrong Liang

doi:10.1117/12.811670

13 March 2009 Implementation of an effective KL domain penalized weighted least-squares sinogram restoration for low-dose CT colonography

Yi Fan, Jing Wang, Hongbing Lu, Zhengrong Liang

Author Affiliations +

Proceedings Volume 7258, Medical Imaging 2009: Physics of Medical Imaging; 725856 (2009) https://doi.org/10.1117/12.811670
Event: SPIE Medical Imaging, 2009, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

Currently available spiral/helical computed tomography (HCT) technologies have demonstrated the potential for CTbased virtual colonoscopy or CT-colonography (CTC). However, a major limitation for this clinical application is associated with the risk of high radiation exposure, especially for its use for screening purpose at a large population. In this work, we presented an improved Karhunen-Loeve (KL) domain penalized weighted least-squares (PWLS) strategy which considers the data correlation among the nearby angular views and nearby axial slices simultaneously so that a fully three-dimensional (3D) restoration problem can be reduced to a 1D operation and therefore an analytical calculation is feasible for highest computing efficiency. The KL-PWLS strategy was implemented and tested on computer simulated sinograms which mimic low-dose CT scans at different noise levels characterized by 50, 40, 30, 20 and 10 mAs respectively. The reconstructed images by the presented strategy demonstrated the potential of ultra low-dose CT at as low as 10 mAs for VC application. Further evaluation by receiver operating characteristic study is needed and is under progress.

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Yi Fan, Jing Wang, Hongbing Lu, and Zhengrong Liang "Implementation of an effective KL domain penalized weighted least-squares sinogram restoration for low-dose CT colonography", Proc. SPIE 7258, Medical Imaging 2009: Physics of Medical Imaging, 725856 (13 March 2009); https://doi.org/10.1117/12.811670

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