Smart velocity ranging quantifiable optical microangiography

Zhongwei Zhi; Ruikang K. Wang

doi:10.1117/12.875712

10 February 2011 Smart velocity ranging quantifiable optical microangiography

Zhongwei Zhi, Ruikang K. Wang

Proceedings Volume 7898, Dynamics and Fluctuations in Biomedical Photonics VIII; 78980K (2011) https://doi.org/10.1117/12.875712
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

We introduce a new type of Optical Microangiography (OMAG) called Quantifiable Optical Microangiography (QOMAG) which is capable of performing quantitative flow imaging with smart velocity ranging. In order to extracting multi-range velocity, two three dimensional data sets need to be acquired at the same imaging area. One data set performs dense scanning in B-scan direction and Doppler analysis was done at the basis of subsequent A-scans, while the other data set performs dense scanning in C-scan direction and Doppler analysis was done at the basis of consecutive B-scan. Since the velocity ranging is determined by the time interval between consecutive measurements of the spectral fringes, longer time interval will give us higher sensitivity to slow velocity. By simultaneous acquiring data sets with different time intervals, we can perform smart velocity ranging quantification on blood flow characterized by different velocity values. The feasibility of QOMAG for variable blood flow imaging is demonstrated by in vivo studies executed on cerebral blood flow of mouse model. Multi-range detailed blood flow map within intracranial Dura mater and cortex of mouse brain can be given by QOMAG.

Citation Download Citation

Zhongwei Zhi and Ruikang K. Wang "Smart velocity ranging quantifiable optical microangiography", Proc. SPIE 7898, Dynamics and Fluctuations in Biomedical Photonics VIII, 78980K (10 February 2011); https://doi.org/10.1117/12.875712

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
4 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Blood circulation

Ranging

Optical coherence tomography

Tissue optics

In vivo imaging

Capillaries

Cerebral blood flow

Show All Keywords

Keywords/Phrases

Search In:

Publication Years