The microfluidic bioagent autonomous networked detector (M-BAND): an update. Fully integrated, automated, and networked field identification of airborne pathogens

M. Sanchez; L. Probst; E. Blazevic; B. Nakao; M. A. Northrup

doi:10.1117/12.898650

13 October 2011 The microfluidic bioagent autonomous networked detector (M-BAND): an update. Fully integrated, automated, and networked field identification of airborne pathogens

M. Sanchez, L. Probst, E. Blazevic, B. Nakao, M. A. Northrup

Author Affiliations +

Proceedings Volume 8189, Optics and Photonics for Counterterrorism and Crime Fighting VII; Optical Materials in Defence Systems Technology VIII; and Quantum-Physics-based Information Security; 818907 (2011) https://doi.org/10.1117/12.898650
Event: SPIE Security + Defence, 2011, Prague, Czech Republic

Abstract

We describe a fully automated and autonomous air-borne biothreat detection system for biosurveillance applications. The system, including the nucleic-acid-based detection assay, was designed, built and shipped by Microfluidic Systems Inc (MFSI), a new subsidiary of PositiveID Corporation (PSID). Our findings demonstrate that the system and assay unequivocally identify pathogenic strains of Bacillus anthracis, Yersinia pestis, Francisella tularensis, Burkholderia mallei, and Burkholderia pseudomallei. In order to assess the assay's ability to detect unknown samples, our team also challenged it against a series of blind samples provided by the Department of Homeland Security (DHS). These samples included natural occurring isolated strains, near-neighbor isolates, and environmental samples. Our results indicate that the multiplex assay was specific and produced no false positives when challenged with in house gDNA collections and DHS provided panels. Here we present another analytical tool for the rapid identification of nine Centers for Disease Control and Prevention category A and B biothreat organisms.

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M. Sanchez, L. Probst, E. Blazevic, B. Nakao, and M. A. Northrup "The microfluidic bioagent autonomous networked detector (M-BAND): an update. Fully integrated, automated, and networked field identification of airborne pathogens", Proc. SPIE 8189, Optics and Photonics for Counterterrorism and Crime Fighting VII; Optical Materials in Defence Systems Technology VIII; and Quantum-Physics-based Information Security, 818907 (13 October 2011); https://doi.org/10.1117/12.898650

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KEYWORDS

Organisms

Microfluidics

Pathogens

Control systems

Luminescence

Sensors

Statistical analysis

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