Tight neurovascular coupling in a rat model of quasi-periodic interictal spiking using multispectral optical imaging

Philippe Pouliot; Van Tri Truong; Cong Zhang; Simon Dubeau; Frédéric Lesage

doi:10.1117/12.2000717

23 October 2012 Tight neurovascular coupling in a rat model of quasi-periodic interictal spiking using multispectral optical imaging

Philippe Pouliot, Van Tri Truong, Cong Zhang, Simon Dubeau, Frédéric Lesage

Author Affiliations +

Proceedings Volume 8412, Photonics North 2012; 841203 (2012) https://doi.org/10.1117/12.2000717
Event: Photonics North 2012, 2012, Montréal, Canada

Abstract

The hemodynamic responses to 4-aminopyridine (4-AP) induced focal epileptic spikes and electrical stimulations are compared in a rat model. Nonlinearities are quantified with biophysical models. Supranormal oxygen consumption from epileptic spikes is inferred. In one recording, interictal spikes followed an almost periodic pattern. Such rhythmic spiking is a well-documented phenomenon in electrophysiological studies, but the hemodynamics correlates have been less studied. Spikes occurred every 12.5 ± 1.0 s. Peaks in total hemoglobin (HbT), a proxy for regional cerebral blood volume, followed spikes by 2.6 ± 0.3 s. Troughs in HbT preceded spikes by 1.68 ± 1.2 s. The narrowness of this distribution is surprising. From it, one may derive a significant but paradoxical fall in HbT several seconds before the spikes, but which this decrease in HbT is better interpreted as being due to the interictal spike that occurred before.

Citation Download Citation

Philippe Pouliot, Van Tri Truong, Cong Zhang, Simon Dubeau, and Frédéric Lesage "Tight neurovascular coupling in a rat model of quasi-periodic interictal spiking using multispectral optical imaging", Proc. SPIE 8412, Photonics North 2012, 841203 (23 October 2012); https://doi.org/10.1117/12.2000717

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