Directing growth cones of optic axons growing with laser scissors and laser tweezers

Tao Wu; Timo A. Nieminen; Samarendra Mohanty; Jill Miotke; Ronald L. Meyer; Halina Rubinsztein-Dunlop; Michael W. Berns

doi:10.1117/12.930411

10 October 2012 Directing growth cones of optic axons growing with laser scissors and laser tweezers

Tao Wu, Timo A. Nieminen, Samarendra Mohanty, Jill Miotke, Ronald L. Meyer, Halina Rubinsztein-Dunlop, Michael W. Berns

Proceedings Volume 8458, Optical Trapping and Optical Micromanipulation IX; 84580P (2012) https://doi.org/10.1117/12.930411
Event: SPIE NanoScience + Engineering, 2012, San Diego, California, United States

Abstract

We have combined a laser scissors and a laser tweezers to study, (1) the response of nerve fiber growth cones to laser-induced damage on single axons, and (2) localized microfluidic flow generated by laser-driven spinning birefringent particles. In the laser scissors study, sub-axotomy damage elicits a growth cone response whether damage is on the same or an adjacent axon. In laser tweezers study, the axon growth cones turn in response to the optically driven microfluidic flow. In summary, both the laser scissors and the laser tweezers studies elicit growth cone turning responses.o

Citation Download Citation

Tao Wu, Timo A. Nieminen, Samarendra Mohanty, Jill Miotke, Ronald L. Meyer, Halina Rubinsztein-Dunlop, and Michael W. Berns "Directing growth cones of optic axons growing with laser scissors and laser tweezers", Proc. SPIE 8458, Optical Trapping and Optical Micromanipulation IX, 84580P (10 October 2012); https://doi.org/10.1117/12.930411

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