Organic nanoparticles as a central plateform of magnetofluorescent nano-assemblies toward two-photon bioimaging applications

Adrien Faucon; Romarik Lenk; Julie Hemez; Eric Gautron; Jérôme Fresnais; Jean-François Berret; Eléna Ishow

doi:10.1117/12.946364

10 October 2012 Organic nanoparticles as a central plateform of magnetofluorescent nano-assemblies toward two-photon bioimaging applications

Adrien Faucon, Romarik Lenk, Julie Hemez, Eric Gautron, Jérôme Fresnais, Jean-François Berret, Eléna Ishow

Author Affiliations +

Proceedings Volume 8464, Nanobiosystems: Processing, Characterization, and Applications V; 84640N (2012) https://doi.org/10.1117/12.946364
Event: SPIE NanoScience + Engineering, 2012, San Diego, California, United States

Abstract

The combined association of magnetic and luminescent properties into a unique object (especially nanoparticle) has recently driven considerable interest since it offers non-invasive dual imaging and permits contactless addressing and vectorization. We report on the use of organic materials, known to emit in the solid state and form size-controlled nanoparticles upon precipitation. They generate cohesive magnetofluorescent hybrid nanospheres without requiring prior coating of the inorganic entities. Their internalization in living cells is successfully proved by two-photon laser scanning fluorescence microscopy and TEM imaging. Deeper photophysical analyses reveal two kinds of structure depending on the solvent and concentration conditions.

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Adrien Faucon, Romarik Lenk, Julie Hemez, Eric Gautron, Jérôme Fresnais, Jean-François Berret, and Eléna Ishow "Organic nanoparticles as a central plateform of magnetofluorescent nano-assemblies toward two-photon bioimaging applications", Proc. SPIE 8464, Nanobiosystems: Processing, Characterization, and Applications V, 84640N (10 October 2012); https://doi.org/10.1117/12.946364

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