Optimization of clinical protocols for contrast enhanced breast imaging

Yue-Houng Hu; David A. Scaduto; Wei Zhao

doi:10.1117/12.2008028

6 March 2013 Optimization of clinical protocols for contrast enhanced breast imaging

Yue-Houng Hu, David A. Scaduto, Wei Zhao

Proceedings Volume 8668, Medical Imaging 2013: Physics of Medical Imaging; 86680G (2013) https://doi.org/10.1117/12.2008028
Event: SPIE Medical Imaging, 2013, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

Contrast enhanced (CE) breast imaging has been proposed as a method to increase the sensitivity and specificity of breast cancer detection. Because malignant lesions often exhibit angiogenesis, the uptake of radio-opaque contrast agents (e.g. iodine) results in increased attenuation compared to the background tissue. Both planar CE digital mammography (CE-DM) and digital breast tomosynthesis (CE-DBT) have been proposed, using temporal or dual energy (DE) subtraction to remove tissue backgrounds. In the current study, we apply a cascaded linear systems model approach to analyze CE techniques with DE subtraction for designing a diagnostic imaging study, including the effects of contrast dynamics. We apply the model for both CE-DM and CE-DBT to calculate the ideal observer signal-to-noise ratio (SNR) for the detection of I contrast objects of different sizes and concentrations. The calculation of this figure-of-merit (FOM) was be used to optimize CE clinical imaging protocols.

Citation Download Citation

Yue-Houng Hu, David A. Scaduto, and Wei Zhao "Optimization of clinical protocols for contrast enhanced breast imaging", Proc. SPIE 8668, Medical Imaging 2013: Physics of Medical Imaging, 86680G (6 March 2013); https://doi.org/10.1117/12.2008028

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available