Dependence of radiation dose on area and volumetric mammographic breast density estimation

H. Jing; B. Keller; Jae Young Choi; R. Crescenzi; E. Conant; A. Maidment; D. Kontos

doi:10.1117/12.2007989

6 March 2013 Dependence of radiation dose on area and volumetric mammographic breast density estimation

H. Jing, B. Keller, Jae Young Choi, R. Crescenzi, E. Conant, A. Maidment, D. Kontos

Proceedings Volume 8668, Medical Imaging 2013: Physics of Medical Imaging; 866827 (2013) https://doi.org/10.1117/12.2007989
Event: SPIE Medical Imaging, 2013, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

Mammographic breast density is a strong risk factor for breast cancer. Studies on imaging dose in mammography have primarily focused on imaging quality and diagnostic accuracy, while little work has been done on understanding its effect on the estimation of breast density. Studies on the effect of dose on mammographic density estimation can be useful in dose reduction for the purpose of density estimation and monitoring. In this study, we investigate the dependence of percent area (PD%) and volumetric (VD%) breast density estimation on imaging dose using an anthropomorphic breast phantom (Rachel, Gammex). A set of digital mammograms were obtained with a GE Senographe 2000D FFDM system, using 220 unique combinations of different imaging physics, namely target/filter, kVp and mAs. Specifically, 8 different mAs settings were defined as corresponding to 10%, 20%, 40%, 70%, 100%, 150%, 200% and 300% of 1.8 mGy reference average glandular dose (AGD) for standard phototimed exposure. Breast density was estimated using fully-automated FDA-cleared software (Quantra v.2.0, Hologic Inc.). The obtained estimates were analyzed to study the effect of the imaging dose, using ANOVA and linear regression. Results show that there is a statistically significant dependence of density estimation on x-ray imaging dose (p-value=0.014 and <0.001 for PD% and VD%, respectively), while the actual variation of the estimation across the different levels of dose is relatively low (standard deviation of 2.87% and 0.66% for PD% and VD% respectively), the differences could be significant when breast density measures are used for risk estimation.

Citation Download Citation

H. Jing, B. Keller, Jae Young Choi, R. Crescenzi, E. Conant, A. Maidment, and D. Kontos "Dependence of radiation dose on area and volumetric mammographic breast density estimation", Proc. SPIE 8668, Medical Imaging 2013: Physics of Medical Imaging, 866827 (6 March 2013); https://doi.org/10.1117/12.2007989

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available