Radiobiology at ultra-high dose rates employing laser-driven ions

F. Hanton; D. Doria; K. F. Kakolee; S. Kar; S. K. Litt; F. Fiorini; H. Ahmed; S. Green; J. C. G. Jeynes; J. Kavanagh; D. Kirby; K. J. Kirkby; C. L. Lewis; M. J. Merchant; G. Nersisyan; R. Prasad; K. Prise; G. Schettino; M. Zpef; M. Borghesi

doi:10.1117/12.2017565

9 May 2013 Radiobiology at ultra-high dose rates employing laser-driven ions

F. Hanton, D. Doria, K. F. Kakolee, S. Kar, S. K. Litt, F. Fiorini, H. Ahmed, S. Green, J. C. G. Jeynes, J. Kavanagh, D. Kirby, K. J. Kirkby, C. L. Lewis, M. J. Merchant, G. Nersisyan, R. Prasad, K. Prise, G. Schettino, M. Zpef, M. Borghesi

Author Affiliations +

Proceedings Volume 8779, Laser Acceleration of Electrons, Protons, and Ions II; and Medical Applications of Laser-Generated Beams of Particles II; and Harnessing Relativistic Plasma Waves III; 87791E (2013) https://doi.org/10.1117/12.2017565
Event: SPIE Optics + Optoelectronics, 2013, Prague, Czech Republic

Abstract

The potential that laser based particle accelerators offer to solve sizing and cost issues arising with conventional proton therapy has generated great interest in the understanding and development of laser ion acceleration, and in investigating the radiobiological effects induced by laser accelerated ions. Laser-driven ions are produced in bursts of ultra-short duration resulting in ultra-high dose rates, and an investigation at Queen’s University Belfast was carried out to investigate this virtually unexplored regime of cell rdaiobiology. This employed the TARANIS terawatt laser producing protons in the MeV range for proton irradiation, with dose rates exceeding 10⁹ Gys^-1 on a single exposure. A clonogenic assay was implemented to analyse the biological effect of proton irradiation on V79 cells, which, when compared to data obtained with the same cell line irradiated with conventionally accelerated protons, was found to show no significant difference. A Relative Biological effectiveness of 1.4±0.2 at 10 % Survival Fraction was estimated from a comparison with a 225 kVp X-ray source.

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F. Hanton, D. Doria, K. F. Kakolee, S. Kar, S. K. Litt, F. Fiorini, H. Ahmed, S. Green, J. C. G. Jeynes, J. Kavanagh, D. Kirby, K. J. Kirkby, C. L. Lewis, M. J. Merchant, G. Nersisyan, R. Prasad, K. Prise, G. Schettino, M. Zpef, and M. Borghesi "Radiobiology at ultra-high dose rates employing laser-driven ions", Proc. SPIE 8779, Laser Acceleration of Electrons, Protons, and Ions II; and Medical Applications of Laser-Generated Beams of Particles II; and Harnessing Relativistic Plasma Waves III, 87791E (9 May 2013); https://doi.org/10.1117/12.2017565

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KEYWORDS

Ions

Laser therapeutics

Biological research

Ion lasers

Laser applications

Cancer

Laser development

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