One-step microencapulation of nanoparticles and perfluorocarbon in
microbubbles for potential application in controlled activation

Guangbin Li; Ting Si; Xisheng Luo; Ronald Xu

doi:10.1117/12.2041062

17 February 2014 One-step microencapulation of nanoparticles and perfluorocarbon in microbubbles for potential application in controlled activation

Guangbin Li, Ting Si, Xisheng Luo, Ronald Xu

Author Affiliations +

Proceedings Volume 8937, Multimodal Biomedical Imaging IX; 89370K (2014) https://doi.org/10.1117/12.2041062
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Silver nanoparticles and perfluorocarbon are encapsulated in multilayered lipid microbubbles by a coaxial electro-flow focusing process. The process is characterized as a coaxial liquid jet in the core of a high-speed coflowing gas stream under an axial electric field. Different flow modes are identified and the stable cone-jet structure is formed in a wide range of process parameters. Core-shell structures of microbubbles with nanoparticles inside the shell are clearly observed. The effects of the main process parameters on the process outcome are studied systemically for the enhanced microbubble morphology. The preliminary elevation of the temperature in silver nanoparticle suspended perfluorcarbon is observed upon exposure to broadband light illumination, indicating the technical potential for light-activated drug delivery.

Citation Download Citation

Guangbin Li, Ting Si, Xisheng Luo, and Ronald Xu "One-step microencapulation of nanoparticles and perfluorocarbon in microbubbles for potential application in controlled activation", Proc. SPIE 8937, Multimodal Biomedical Imaging IX, 89370K (17 February 2014); https://doi.org/10.1117/12.2041062

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