Spectroscopic imaging of blood vessels only near the skin surface for non-invasive blood glucose measurement

Masaru Fujiwara; Shun Sato; Pradeep K. W. Abeygunawardhana; Satoru Suzuki; Akira Nishiyama; Kenji Wada; Ichiro Ishimaru

doi:10.1117/12.2183671

15 July 2015 Spectroscopic imaging of blood vessels only near the skin surface for non-invasive blood glucose measurement

Masaru Fujiwara, Shun Sato, Pradeep K. W. Abeygunawardhana, Satoru Suzuki, Akira Nishiyama, Kenji Wada, Ichiro Ishimaru

Author Affiliations +

Proceedings Volume 9537, Clinical and Biomedical Spectroscopy and Imaging IV; 953714 (2015) https://doi.org/10.1117/12.2183671
Event: European Conferences on Biomedical Optics, 2015, Munich, Germany

Abstract

To realize the non-invasive blood glucose measurement, it will be effective to acquire the spectroscopic imaging of blood vessels only near the skin surface for eliminating other biological-component’s disturbances. Our proposed imaging-type 2-dimensional Fourier spectroscopic imaging can limit the measuring depth into focal plane with high light detection sensitivity. Thus, the proposed method will be suitable for measuring only near the skin surface with detecting weak reflected light from inner biomembrane. But reflectance of skin surface is more than 1000 times larger than inner skin’s reflectance. Paying attention on Fresnel reflection, fingers what were illuminated by p-polarized beam from Brewster's angle were observed with crossed-Nicol dark field optics. We successfully acquired spectroscopic characteristics of hemoglobin at vein area near the skin surface.

Citation Download Citation

Masaru Fujiwara, Shun Sato, Pradeep K. W. Abeygunawardhana, Satoru Suzuki, Akira Nishiyama, Kenji Wada, and Ichiro Ishimaru "Spectroscopic imaging of blood vessels only near the skin surface for non-invasive blood glucose measurement", Proc. SPIE 9537, Clinical and Biomedical Spectroscopy and Imaging IV, 953714 (15 July 2015); https://doi.org/10.1117/12.2183671

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available