Time-resolved transmittance: a comparison of the diffusion model approach with Monte Carlo simulations

Ramona Rothfischer; Dirk Grosenick; Rainer Macdonald

doi:10.1117/12.2183762

16 July 2015 Time-resolved transmittance: a comparison of the diffusion model approach with Monte Carlo simulations

Ramona Rothfischer, Dirk Grosenick, Rainer Macdonald

Proceedings Volume 9538, Diffuse Optical Imaging V; 95381H (2015) https://doi.org/10.1117/12.2183762
Event: European Conferences on Biomedical Optics, 2015, Munich, Germany

Abstract

We discuss the determination of optical properties of thick scattering media from measurements of time-resolved transmittance by diffusion theory using Monte Carlo simulations as a gold standard to model photon migration. Our theoretical and experimental investigations reveal differences between calculated distributions of times of flight (DTOFs) of photons from both models which result in an overestimation of the absorption and the reduced scattering coefficient by diffusion theory which becomes larger for small scattering coefficients. By introducing a temporal shift in the DTOFs obtained with the diffusion model as additional fit parameter, the deviation in the absorption coefficient can be compensated almost completely. If the scattering medium is additionally covered by transparent layers (e.g. glass plates) the deviation between the DTOFs from both models is even larger which mainly effects the determination of the reduced scattering coefficient by diffusion theory. A temporal shift improves the accuracy of the optical properties derived by diffusion theory in this case as well.

Citation Download Citation

Ramona Rothfischer, Dirk Grosenick, and Rainer Macdonald "Time-resolved transmittance: a comparison of the diffusion model approach with Monte Carlo simulations", Proc. SPIE 9538, Diffuse Optical Imaging V, 95381H (16 July 2015); https://doi.org/10.1117/12.2183762

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available