Fluorescence anisotropy characterization of urine in the diagnosis of cancer

Ramu Rajasekaran; Elumalai Brindha; Shanmugam Sivabalan; Prakasa Rao Aruna; Dornadula Koteeswaran; Singaravelu Ganesan

doi:10.1117/12.2212618

7 March 2016 Fluorescence anisotropy characterization of urine in the diagnosis of cancer

Ramu Rajasekaran, Elumalai Brindha, Shanmugam Sivabalan, Prakasa Rao Aruna, Dornadula Koteeswaran, Singaravelu Ganesan

Proceedings Volume 9703, Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis; 97031P (2016) https://doi.org/10.1117/12.2212618
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Cervical cancer is considered as the second most commonly occurring malignancy among women, next to breast cancer. It is well known that most of the cancer patients diagnosed with advanced stages and there is a pressing need for improved methods to detect cancer at its initial stages. Many techniques have been adopted for the diagnosis of cervical cancer. Among these, fluorescence polarization spectroscopy is a complementary technique of fluorescence spectroscopy which helps us to elucidate the spectral characteristics which highly depend on pH, viscosity and local environment. Since urine has many metabolites and the measurement of native fluorescence of urine, in principle, able to provide an indication of a number of health conditions, attempts were made to study fluorescence anisotropic characterization of the human urine of cervical cancer patients and normal subjects. Significant differences were observed between the anisotropic and polarization values of cancer subjects and normal subjects.

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Ramu Rajasekaran, Elumalai Brindha, Shanmugam Sivabalan, Prakasa Rao Aruna, Dornadula Koteeswaran, and Singaravelu Ganesan "Fluorescence anisotropy characterization of urine in the diagnosis of cancer", Proc. SPIE 9703, Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis, 97031P (7 March 2016); https://doi.org/10.1117/12.2212618

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KEYWORDS

Cancer

Luminescence

Polarization

Cervical cancer

Anisotropy

Fluorescence spectroscopy

Spectroscopy

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