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We report a novel multispectral FLIm/ swept-source OCT intravascular imaging catheter system including three key innovative features: 1) UV/NIR beam focusing is achieved with a free-form reflective distal optics that outperforms both ball and GRIN-based catheter optics, 2) stable optical coupling (single mode transmission: 75.7+-0.5% at 100 rps) by way of an air bearing rotary collimator, and 3) improvements in FLIm SNR obtained by integrating solid-state FLIm detection within the motor drive. Validation in excised human coronary artery specimens demonstrates the capabilities of FLIm to detect and quantify inflammation and characterize the extracellular matrix of atherosclerotic lesions.
Julien Bec,Cai Li,Xiangnan Zhou,Deborah Vela, andLaura Marcu
"Evaluation of a high-performance FLIm/OCT catheter system for biochemical and structural evaluation of atherosclerosis", Proc. SPIE PC11936, Diagnostic and Therapeutic Applications of Light in Cardiology 2022, PC1193604 (7 March 2022); https://doi.org/10.1117/12.2607844
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Julien Bec, Cai Li, Xiangnan Zhou, Deborah Vela, Laura Marcu, "Evaluation of a high-performance FLIm/OCT catheter system for biochemical and structural evaluation of atherosclerosis," Proc. SPIE PC11936, Diagnostic and Therapeutic Applications of Light in Cardiology 2022, PC1193604 (7 March 2022); https://doi.org/10.1117/12.2607844