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13 October 2022 Rapid analysis of single proteins and their interactions with accessible aperture-based tweezers
Reuven Gordon
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Proceedings Volume PC12198, Optical Trapping and Optical Micromanipulation XIX; PC1219806 (2022) https://doi.org/10.1117/12.2633083
Event: SPIE Nanoscience + Engineering, 2022, San Diego, California, United States
Abstract
This presentation will focus on enhancing the usability of double-nanohole (DNH) optical tweezers in protein analysis applications. We will compare the technique with existing label-free and tether-free methods, showing that the DNH has an order of magnitude lower limit of detection and higher sensitivity. We will also present advances for low-cost and high-througput analysis, with applications to drug discovery, drug validation and biologics. We will also discuss applications to the analysis of perovskite quantum dots.
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Reuven Gordon "Rapid analysis of single proteins and their interactions with accessible aperture-based tweezers", Proc. SPIE PC12198, Optical Trapping and Optical Micromanipulation XIX, PC1219806 (13 October 2022); https://doi.org/10.1117/12.2633083
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KEYWORDS
Proteins
Biological research
Drug discovery
Optical tweezers
Perovskite
Quantum dots
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