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3 October 2022 Can we control the trans-membrane ion exchange by using amphiphilic azobenzene molecules (Conference Presentation)
Tigran Galstian, Ilham Touati, Yue Zhao
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Proceedings Volume PC12212, Molecular and Nano Machines V; PC1221206 (2022) https://doi.org/10.1117/12.2635898
Event: SPIE Organic Photonics + Electronics, 2022, San Diego, California, United States
Abstract
We have already reported the use of commercial Azobenzene molecules for the control of biological membranes. In the current work we have synthesized Azobenzene molecules that have both hydrophobic and hydrophilic opposed ends. Our working hypothesis is that the increased affinity of such molecules with amphiphilic molecules of the biological membrane will increase the impact of photo induced isomerization on the ionic exchange processes across the membrane. However, our preliminary results show that these molecules adopt relatively stable Trans and Cis isomers. The thermal isomerization of newly created (by using UV light) Cis molecules into their Trans form is almost inexistant. Thus, the process of isomerization is saturated quickly. This is the reason why we use a second (visible) light source to initiate the back photo isomerization and to maintain the continuous Trans-Cis and Cis-Trans isomerization process. The corresponding spectral investigations in water and mobility media as well as bacterial systems will be reported.
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Tigran Galstian, Ilham Touati, and Yue Zhao "Can we control the trans-membrane ion exchange by using amphiphilic azobenzene molecules (Conference Presentation)", Proc. SPIE PC12212, Molecular and Nano Machines V, PC1221206 (3 October 2022); https://doi.org/10.1117/12.2635898
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KEYWORDS
Molecules
Ion exchange
Molecular biology
Ultraviolet radiation
Visible radiation
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