Exploration of photoacoustic remote sensing virtual histology in skin malignancies

Benjamin R. Ecclestone; James Tweel; Krystal Li; Hager Gaouda; Kevan Bell; Deepak Dinakaran; Muba Taher; John Mackey; Parsin Haji Reza

doi:10.1117/12.2650980

17 March 2023 Exploration of photoacoustic remote sensing virtual histology in skin malignancies

Benjamin R. Ecclestone, James Tweel, Krystal Li, Hager Gaouda, Kevan Bell, Deepak Dinakaran, Muba Taher, John Mackey, Parsin Haji Reza

Author Affiliations +

Proceedings Volume PC12352, Photonics in Dermatology and Plastic Surgery 2023; PC1235201 (2023) https://doi.org/10.1117/12.2650980
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Label-free virtual-histology of skin tissues using a Photoacoustic Remote Sensing (PARS) microscope is explored. The PARS captures optical absorption contrast facilitating label-free imaging of numerous biomolecules. Combined with AI-based image processing, PARS provides virtual histology images label-free directly from unprocessed tissues. The label-free contrast means several virtual stains may be applied to each tissue section. Subsequent results are explored in unprocessed human skin with basal cell carcinoma, and squamous cell carcinoma. Clinical comparison studies indicate there is similar diagnostic quality between the PARS and gold-standard histology preparations. This represents a significant milestone in the development of a clinically ready microscope for label-free skin cancer histology.

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Benjamin R. Ecclestone, James Tweel, Krystal Li, Hager Gaouda, Kevan Bell, Deepak Dinakaran, Muba Taher, John Mackey, and Parsin Haji Reza "Exploration of photoacoustic remote sensing virtual histology in skin malignancies", Proc. SPIE PC12352, Photonics in Dermatology and Plastic Surgery 2023, PC1235201 (17 March 2023); https://doi.org/10.1117/12.2650980

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