The potential application of PS-OCT in the safety assessment of non-steroidal topical creams for atopic dermatitis treatment

Mengqiu Duan; Robert Byers; Simon G. Danby; Rosie N. Taylor; Amy Cha; Roni Adiri; Chuanbo Zang; John Werth; Michael J. Cork; Stephen J. Matcher

doi:10.1117/12.2647545

17 March 2023 The potential application of PS-OCT in the safety assessment of non-steroidal topical creams for atopic dermatitis treatment

Mengqiu Duan, Robert Byers, Simon G. Danby, Rosie N. Taylor, Amy Cha, Roni Adiri, Chuanbo Zang, John Werth, Michael J. Cork, Stephen J. Matcher

Author Affiliations +

Proceedings Volume PC12352, Photonics in Dermatology and Plastic Surgery 2023; PC123520F (2023) https://doi.org/10.1117/12.2647545
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Crisaborole 2% ointment is a non-steroidal treatment for mild-moderate atopic dermatitis (AD) and may have a better safety profile than topical corticosteroids (TCS), which produce pronounced epidermal atrophy. In this study we compared crisaborole to betamethasone valerate (BMV) in terms of changes to dermal collagen, using PS-OCT to quantify dermal birefringence. 37 subjects were enrolled in this study, which involved daily application of BMV & crisaborole. Results showed BMV produced a significant increase in dermal birefringence, whereas crisaborole showed no significant change. PS-OCT may thus have an important role in the safety assessment of non-steroidal alternatives to TCS.

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Mengqiu Duan, Robert Byers, Simon G. Danby, Rosie N. Taylor, Amy Cha, Roni Adiri, Chuanbo Zang, John Werth, Michael J. Cork, and Stephen J. Matcher "The potential application of PS-OCT in the safety assessment of non-steroidal topical creams for atopic dermatitis treatment", Proc. SPIE PC12352, Photonics in Dermatology and Plastic Surgery 2023, PC123520F (17 March 2023); https://doi.org/10.1117/12.2647545

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KEYWORDS

Safety

Collagen

Image segmentation

Optical coherence tomography

Birefringence

Microscopy

Second-harmonic generation

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