Indocyanine green-based in-vivo photoacoustic imaging contrast agent platform

Shrishti Singh; Giovanni Giammanco; Chih-hsiang Hu; Joshua Bush; Leandro S. Cordova; Dylan J. Lawrence; Jeffrey Oğuz L. Moran; Parag Chitnis; Remi Veneziano

doi:10.1117/12.2650123

9 March 2023 Indocyanine green-based in-vivo photoacoustic imaging contrast agent platform

Shrishti Singh, Giovanni Giammanco, Chih-hsiang Hu, Joshua Bush, Leandro S. Cordova, Dylan J. Lawrence, Jeffrey Oğuz L. Moran, Parag Chitnis, Remi Veneziano

Author Affiliations +

Proceedings Volume PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023; PC123790O (2023) https://doi.org/10.1117/12.2650123
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

We developed an indocyanine green J-aggregated (ICG-JA) nanoparticle platform for near infrared photoacoustic imaging (NIR-PAI). This platform achieves a facile synthesis, size tunability and direct functionalization. In an in vitro setting, we compared the PA signal of ICG-JA (at its optical absorption peak of 895 nm) to be two times that of whole blood. We then imaged HeLa cells with ICG-JA functionalized with RGD-peptide using NIR-PAI. Using a multi-wavelength NIR-PAI system, TriTom™, volumetric whole-body images were acquired of mice administed with RGD-peptide functionalized ICG-JA. Results indicated enhanced visualization of the liver, spleen and thoracic arteries with a contrast-to-noise-ratio of 2.42.

Conference Presentation

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Shrishti Singh, Giovanni Giammanco, Chih-hsiang Hu, Joshua Bush, Leandro S. Cordova, Dylan J. Lawrence, Jeffrey Oğuz L. Moran, Parag Chitnis, and Remi Veneziano "Indocyanine green-based in-vivo photoacoustic imaging contrast agent platform", Proc. SPIE PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023, PC123790O (9 March 2023); https://doi.org/10.1117/12.2650123

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KEYWORDS

In vivo imaging

Photoacoustic imaging

Absorption

Imaging systems

Near infrared

Tissue optics

Nanoparticles

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