Characterizing intestinal fibrosis using endoscopic strain-photoacoustic and spectroscopic imaging

Linyu Ni; Xiaorui Peng; Laura Johnson; Kathryn A. Eaton; Jonathan Rubin; Peter Higgins M.D.; Xueding Wang; Guan Xu; Yunhao Zhu; Guorong Hu

doi:10.1117/12.2649219

9 March 2023 Characterizing intestinal fibrosis using endoscopic strain-photoacoustic and spectroscopic imaging

Linyu Ni, Xiaorui Peng, Laura Johnson, Kathryn A. Eaton, Jonathan Rubin, Peter Higgins M.D., Xueding Wang, Guan Xu, Yunhao Zhu, Guorong Hu

Author Affiliations +

Proceedings Volume PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023; PC123790S (2023) https://doi.org/10.1117/12.2649219
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Quantification of fibrosis is critical for the management of inflammatory bowel disease. In this study, two measurements, collagen-to-Hb ratio quantified by spectroscopic analysis and tissue stiffness quantified by PA-strain, measured by our PA-US balloon catheter were employed to quantify intestinal fibrosis in 23 rabbits in vivo. Results show that both measurements can distinguish the low histological fibrosis (0-2) and high histological fibrosis (3-5) with statistical significance (p-value<0.001). Collagen-to-Hb ratio and PA-strain are highly correlated with the fibrosis stages with correlation of 0.67 and 0.64, respectively. PA-strain is positively correlated to Young’s Modulus measured ex vivo using microelastometer with correlation 0.81.

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Citation Download Citation

Linyu Ni, Xiaorui Peng, Laura Johnson, Kathryn A. Eaton, Jonathan Rubin, Peter Higgins M.D., Xueding Wang, Guan Xu, Yunhao Zhu, and Guorong Hu "Characterizing intestinal fibrosis using endoscopic strain-photoacoustic and spectroscopic imaging", Proc. SPIE PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023, PC123790S (9 March 2023); https://doi.org/10.1117/12.2649219

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