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16 March 2023 Electrochemiluminescence detection of uric acid at point-of-need by using a lab-on-a-CMOS platform (Conference Presentation)
Reza Abbasi, Juanjuan Liu, Sorina Maria Suarasan, Sebastian Wachsmann-Hogiu
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Proceedings Volume PC12394, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XX; PC1239403 (2023) https://doi.org/10.1117/12.2656342
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
A complex instrument is ordinarily used in electrochemiluminescence (ECL) biosensors to monitor the emitted light from the chemiluminescence reaction. As a result, these biosensors may not be suitable for point-of-need (PON) testing, which is critical in healthcare diagnostics. Microfluidic and luminol-based ECL systems were integrated on a CMOS chip to create a miniaturized ECL sensor for PON applications in this study. The findings demonstrated that this novel lab-on-a-chip system could detect uric acid levels as an essential biomarker for diagnosing gout disease in urine and saliva at levels lower than the physiological range. The device's repeatability, reproducibility, and selectivity were also investigated.
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Reza Abbasi, Juanjuan Liu, Sorina Maria Suarasan, and Sebastian Wachsmann-Hogiu "Electrochemiluminescence detection of uric acid at point-of-need by using a lab-on-a-CMOS platform (Conference Presentation)", Proc. SPIE PC12394, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XX, PC1239403 (16 March 2023); https://doi.org/10.1117/12.2656342
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KEYWORDS
Photons
Diagnostics
Digital recording
Microfluidics
Microscopes
Photodetectors
Sensors
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