CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume PC12822 > Article
Presentation
13 March 2024 Prevention of ventilation-associated pneumonia by applying a functionalized endotracheal tube and photodynamic therapy
Amanda Cristina Zangirolami, Vanderlei Salvador Bagnato, Kate Cristina Blanco
Author Affiliations +
Proceedings Volume PC12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024; PC128220F (2024) https://doi.org/10.1117/12.3001094
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
The pandemic SARS-CoV-2 exacerbated the number of intubated patients, because of the worst form of the disease cause respiratory failure. Endotracheal tubes are placed to facilitate gas exchange and intubated patient has a major risk (5-40%) of developing Ventilator Associated Pneumonia, where half of this number happen to die. Functionalization in polymeric materials, associated to photodynamic therapy, is a strategy which has been applied with success to avoid and decontaminated biofilms in medical devices. This study developed a curcumin-functionalized ET by applying photodynamic therapy inactivate different bacterial biofilm species associated with PAV. Cytotoxicity assays hasn’t revealed any toxic effect in mammal cells and the respiratory system model support that the functionalized tube when irradiated can act such as a photodynamic barrier to avoid the infection spread and reach the lungs. In vivo studies were performed in pigs intubated and ventilated for 24h and the animals intubated with the functionalized tube and irradiated showed a significant reduction of biofilm development, without adverse effects in oral, tracheal and pulmonary mucosa.
Conference Presentation
© (2024) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Amanda Cristina Zangirolami, Vanderlei Salvador Bagnato, and Kate Cristina Blanco "Prevention of ventilation-associated pneumonia by applying a functionalized endotracheal tube and photodynamic therapy", Proc. SPIE PC12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024, PC128220F (13 March 2024); https://doi.org/10.1117/12.3001094
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Photodynamic therapy
Biofilms
Fiber coupled lasers
Medical devices
Polymers
Laser irradiation
Lung
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top