High throughput low cost microfluidic interferometric chamber for RBC disease detection

Cindy X. Chen; Adam Wax

doi:10.1117/12.3001149

13 March 2024 High throughput low cost microfluidic interferometric chamber for RBC disease detection

Cindy X. Chen, Adam Wax

Proceedings Volume PC12854, Label-free Biomedical Imaging and Sensing (LBIS) 2024; PC128540T (2024) https://doi.org/10.1117/12.3001149
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

High throughput quantitative phase imaging show immense potential for clinical applications in various disease detection, however, traditional interferometric setups on optical benchtops are bulky and expensive by design. We present a low-cost, compact interferometric chamber system that would consist of merely three lenses and one beam splitter. The presented system can provide high throughput single-cell level screening of million cell sample population. In combination with customized dataset refinement algorithm and machine learning, we developed a novel technique that would allow for detection of RBC morphology-altering diseases such as sickle cell disease.

Conference Presentation

Citation Download Citation

Cindy X. Chen and Adam Wax "High throughput low cost microfluidic interferometric chamber for RBC disease detection", Proc. SPIE PC12854, Label-free Biomedical Imaging and Sensing (LBIS) 2024, PC128540T (13 March 2024); https://doi.org/10.1117/12.3001149

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available