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13 March 2024 Hyperspectral stimulated Raman imaging with a turn-key imaging system based on a compact fiber laser and balanced detection
Tim Hellwig, Niklas Lüpken, Sven Dobner, Felix Neumann, Ramon Droop, Christoph Engwer, Maryam Rezaei, Maximilian Brinkmann
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Proceedings Volume PC12855, Advanced Chemical Microscopy for Life Science and Translational Medicine 2024; PC128550H (2024) https://doi.org/10.1117/12.3001381
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Hyperspectral Stimulated Raman Imaging (SRS) has shown great promise as a label-free chemical imaging technique in biomedical and medical research. We present recent developments in SRS integrating a compact and portable all-fiber laser with balanced detection into an imaging system, aiming to enhance ease-of-use, specificity, and reliability in acquiring high-speed, multicolor chemical images. The system's adaptability is highlighted by its seamless integration with a Nikon Eclipse Ti widefield microscope, providing a compact and robust extension for varied imaging setups. The system incorporates a balanced detector to enable shot-noise-limited measurements, accommodating over 100mW of Stokes power on the detector.
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Tim Hellwig, Niklas Lüpken, Sven Dobner, Felix Neumann, Ramon Droop, Christoph Engwer, Maryam Rezaei, and Maximilian Brinkmann "Hyperspectral stimulated Raman imaging with a turn-key imaging system based on a compact fiber laser and balanced detection", Proc. SPIE PC12855, Advanced Chemical Microscopy for Life Science and Translational Medicine 2024, PC128550H (13 March 2024); https://doi.org/10.1117/12.3001381
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KEYWORDS
Imaging systems
Biomedical optics
Hyperspectral imaging
Raman spectroscopy
Fiber lasers
Medical research
Medical diagnostics
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