A numerical model for quantitative photoacoustic spectroscopy of contrast agents

Marzieh Ezzatpour; Farzin Ghane Golmohamadi; Jan Laufer

doi:10.1117/12.3017064

20 June 2024 A numerical model for quantitative photoacoustic spectroscopy of contrast agents

Marzieh Ezzatpour, Farzin Ghane Golmohamadi, Jan Laufer

Proceedings Volume PC13006, Biomedical Spectroscopy, Microscopy, and Imaging III; PC130060H (2024) https://doi.org/10.1117/12.3017064
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Abstract

The development of photoacoustic contrast agents relies on the recovery of the photophysical properties from cuvette measurements. Photoacoustic signals are typically described using the Beer-Lambert law. In contrast agents with long excited state lifetimes, it is no longer valid. This is particularly noticeable at low concentrations and short cuvette pathlengths as acoustic propagation and detection effects become significant. A forward model is used to calculate time-resolved signals generated in a cuvette. The model is fitted to measured signals to recover absorption coefficients. The model will enable the characterization of new contrast agents by recovering the spatial distribution of thermalized energy.

Conference Presentation

Citation Download Citation

Marzieh Ezzatpour, Farzin Ghane Golmohamadi, and Jan Laufer "A numerical model for quantitative photoacoustic spectroscopy of contrast agents", Proc. SPIE PC13006, Biomedical Spectroscopy, Microscopy, and Imaging III, PC130060H (20 June 2024); https://doi.org/10.1117/12.3017064

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