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20 June 2024 Precision in dynamic light scattering optical coherence tomography measurements of diffusion and flow
Konstantine Cheishvili
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Proceedings Volume PC13006, Biomedical Spectroscopy, Microscopy, and Imaging III; PC130060K (2024) https://doi.org/10.1117/12.3016243
Event: SPIE Photonics Europe, 2024, Strasbourg, France
Abstract
We quantify the precision and bias of dynamic light scattering optical coherence tomography (DLS-OCT) measurements of the diffusion coefficient and flow speed for first and second-order normalized autocovariance functions. For both diffusion and flow the measurement precision and accuracy are severely limited by correlations between the errors in the normalized autocovariance function. We demonstrate a method of mixing statistically independent normalized autocovariance functions at every time delay for removing these correlations. The mixing method reduces the uncertainty in the obtained parameters by a factor of two but has no effect on the standard error of the mean. We find that the precision in DLS-OCT is identical for different averaging techniques, but that the lowest bias is obtained by averaging the measured correlation functions before fitting the model parameters. With our correlation mixing method it is possible to quantify the precision in DLS-OCT and verify whether the Cramer-Rao bound is reached.
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(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.
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Konstantine Cheishvili "Precision in dynamic light scattering optical coherence tomography measurements of diffusion and flow", Proc. SPIE PC13006, Biomedical Spectroscopy, Microscopy, and Imaging III, PC130060K (20 June 2024); https://doi.org/10.1117/12.3016243
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KEYWORDS
Diffusion
Optical coherence tomography
Dynamic light scattering
Particles
Doppler tomography
Motion analysis
Motion measurement
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