Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements

Stefan A. Carp; Tina Kauffman; Qianqian Fang; Elizabeth A. Rafferty; Richard H. Moore; Daniel B. Kopans; David A. Boas

doi:10.1117/1.2397572

1 November 2006 Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements

Stefan A. Carp, Tina Kauffman, Qianqian Fang, Elizabeth A. Rafferty, Richard H. Moore, Daniel B. Kopans, David A. Boas

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Journal of Biomedical Optics, Vol. 11, Issue 6, 064016 (November 2006). https://doi.org/10.1117/1.2397572

Abstract

We use optical spectroscopy to characterize the influence of mammographic-like compression on the physiology of the breast. We note a reduction in total hemoglobin content, tissue oxygen saturation, and optical scattering under compression. We also note a hyperemic effect during repeated compression cycles. By modeling the time course of the tissue oxygen saturation, we are able to obtain estimates for the volumetric blood flow (1.64±0.6 mL/100 mL/min) and the oxygen consumption (1.97±0.6 μmol/100 mL/min) of compressed breast tissue. These values are comparable to estimates obtained from previously published positron emission tomography (PET) measurements. We conclude that compression-induced changes in breast physiological properties are significant and should be accounted for when performing optical breast imaging. Additionally, the dynamic characteristics of the changes in breast physiological parameters, together with the ability to probe the tissue metabolic state, may prove useful for breast cancer detection.

©(2006) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Stefan A. Carp, Tina Kauffman, Qianqian Fang, Elizabeth A. Rafferty, Richard H. Moore, Daniel B. Kopans, and David A. Boas "Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements," Journal of Biomedical Optics 11(6), 064016 (1 November 2006). https://doi.org/10.1117/1.2397572

Published: 1 November 2006

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