Dynamic eye phantom for retinal oximetry measurements

Paul Lemaillet; Jessica C. Ramella-Roman

doi:10.1117/1.3258669

1 November 2009 Dynamic eye phantom for retinal oximetry measurements

Paul Lemaillet, Jessica C. Ramella-Roman

Author Affiliations +

Journal of Biomedical Optics, Vol. 14, Issue 6, 064008 (November 2009). https://doi.org/10.1117/1.3258669

Abstract

Measurements of oxygen saturation and flow in the retina can yield information about eye health and the onset of eye pathologies such as diabetic retinopathy. Recently, we developed a multiaperture camera that uses the division of the retinal image into several wavelength-sensitive subimages to compute retinal oxygen saturation. The calibration of such instruments is particularly difficult due to the layered structure of the eye and the lack of alternative measurement techniques. For this purpose, we realize an in vitro model of the human eye composed of a lens, the retina vessel, and three layers: the choroid, the retinal pigmented epithelium, and the sclera. The retinal vessel is modeled with a microtube connected to a micropump and a hemoglobin reservoir in a closed circulatory system. Hemoglobin oxygenation in the vessel could be altered using a reversible fuel cell. The sclera is represented by a Spectralon slab. The optical properties of the other layers are mimicked using titanium dioxide as a scatterer, ink as an absorber, and epoxy as a supporting structure. The optical thickness of each layer of the eye phantom is matched to each respective eye layer.

©(2009) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Paul Lemaillet and Jessica C. Ramella-Roman "Dynamic eye phantom for retinal oximetry measurements," Journal of Biomedical Optics 14(6), 064008 (1 November 2009). https://doi.org/10.1117/1.3258669

Published: 1 November 2009

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Cited by 12 scholarly publications and 1 patent.

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KEYWORDS

Eye

Oxygen

Scattering

Eye models

Optical properties

Blood

Reflectivity

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