Real-time, closed-loop dual-wavelength optical polarimetry for glucose monitoring

Bilal H. Malik; Gerard L. Coté

doi:10.1117/1.3290819

1 January 2010 Real-time, closed-loop dual-wavelength optical polarimetry for glucose monitoring

Bilal H. Malik, Gerard L. Coté

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Journal of Biomedical Optics, Vol. 15, Issue 1, 017002 (January 2010). https://doi.org/10.1117/1.3290819

Abstract

The development of a real-time, dual-wavelength optical polarimetric system to ultimately probe the aqueous humor glucose concentrations as a means of noninvasive diabetic glucose monitoring is the long-term goal of this research. The key impact of the work is the development of an approach for the reduction of the time-variant corneal birefringence due to motion artifact, which is still a limiting factor preventing the realization of such a device. Our dual-wavelength approach utilizes real-time, closed-loop feedback that employs a classical three-term feedback controller and efficiently reduces the effect of motion artifact that appears as a common noise source for both wavelengths. In vitro results are shown for the open-loop system, and although the dual-wavelength system helps to reduce the noise, it is shown that closed-loop control is necessary to bring the noise down to a sufficient level for physiological monitoring. Specifically, in vitro measurement results with the closed-loop dual-wavelength approach demonstrate a sensitivity of 12.8 mg/dl across the physiologic glucose range in the presence of time-variant test cell birefringence. Overall, it is shown that this polarimetric system has the potential to be used as a noninvasive measure of glucose for diabetes.

©(2010) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Bilal H. Malik and Gerard L. Coté "Real-time, closed-loop dual-wavelength optical polarimetry for glucose monitoring," Journal of Biomedical Optics 15(1), 017002 (1 January 2010). https://doi.org/10.1117/1.3290819

Published: 1 January 2010

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