Effects of motion on optical properties in the spatial frequency domain

John Quan M. Nguyen; Rolf B. Saager; Anthony J. Durkin; David J. Cuccia; Kristen M. Kelly; James Jakowatz; David J. Hsiang

doi:10.1117/1.3662454

1 December 2011 Effects of motion on optical properties in the spatial frequency domain

John Quan M. Nguyen, Rolf B. Saager, Anthony J. Durkin, David J. Cuccia, Kristen M. Kelly, James Jakowatz, David J. Hsiang

Author Affiliations +

Journal of Biomedical Optics, Vol. 16, Issue 12, 126009 (December 2011). https://doi.org/10.1117/1.3662454

Abstract

Spatial frequency domain imaging (SFDI) is a noncontact and wide-field optical imaging technology currently being used to study the optical properties and chromophore concentrations of in vivo skin including skin lesions of various types. Part of the challenge of developing a clinically deployable SFDI system is related to the development of effective motion compensation strategies, which in turn, is critical for recording high fidelity optical properties. Here we present a two-part strategy for SFDI motion correction. After verifying the effectiveness of the motion correction algorithm on tissue-simulating phantoms, a set of skin-imaging data was collected in order to test the performance of the correction technique under real clinical conditions. Optical properties were obtained with and without the use of the motion correction technique. The results indicate that the algorithm presented here can be used to render optical properties in moving skin surfaces with fidelities within 1.5% of an ideal stationary case and with up to 92.63% less variance. Systematic characterization of the impact of motion variables on clinical SFDI measurements reveals that until SFDI instrumentation is developed to the point of instantaneous imaging, motion compensation is necessary for the accurate localization and quantification of heterogeneities in a clinical setting.

Citation Download Citation

John Quan M. Nguyen, Rolf B. Saager, Anthony J. Durkin, David J. Cuccia, Kristen M. Kelly, James Jakowatz, and David J. Hsiang "Effects of motion on optical properties in the spatial frequency domain," Journal of Biomedical Optics 16(12), 126009 (1 December 2011). https://doi.org/10.1117/1.3662454

Published: 1 December 2011

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
10 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY