In vivo estimation of elastic wave parameters using phase-stabilized swept source optical coherence elastography

Ravi K. Manapuram; Salavat R. Aglyamov; Floredes M. Monediado; Maleeha Mashiatulla; Jiasong Li; Stanislav Y. Emelianov; Kirill V. Larin

doi:10.1117/1.JBO.17.10.100501

26 September 2012 In vivo estimation of elastic wave parameters using phase-stabilized swept source optical coherence elastography

Ravi K. Manapuram, Salavat R. Aglyamov, Floredes M. Monediado, Maleeha Mashiatulla, Jiasong Li, Stanislav Y. Emelianov, Kirill V. Larin

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Journal of Biomedical Optics, Vol. 17, Issue 10, 100501 (September 2012). https://doi.org/10.1117/1.JBO.17.10.100501

Abstract

We report a highly sensitive method based on phase-stabilized swept source optical coherence elastography (PhS-SSOCE) to measure elastic wave propagation in soft tissues in vivo. The waves were introduced using a mechanical stimulus and were assessed using the phase response of the swept source optical coherence tomography signal. The technique was utilized to measure age-related changes in elastic flexural wave velocity and attenuation in mice cornea in vivo. Results demonstrate that the wave velocity increases with animal age, supporting previous observations that stiffness of mice cornea gradually increases with age. Our studies suggest that the PhS-SSOCE technique could potentially be used to obtain biomechanical properties of ocular tissues in vivo.

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Ravi K. Manapuram, Salavat R. Aglyamov, Floredes M. Monediado, Maleeha Mashiatulla, Jiasong Li, Stanislav Y. Emelianov, and Kirill V. Larin "In vivo estimation of elastic wave parameters using phase-stabilized swept source optical coherence elastography," Journal of Biomedical Optics 17(10), 100501 (26 September 2012). https://doi.org/10.1117/1.JBO.17.10.100501

Published: 26 September 2012

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