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4 May 2012 Lifetime-based photoacoustic oxygen sensing in vivo
Aniruddha Ray, Raoul Kopelman, Justin R. Rajian, Xueding Wang, Yong-Eun K. Lee
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Journal of Biomedical Optics, Vol. 17, Issue 5, 057004 (May 2012). https://doi.org/10.1117/1.JBO.17.5.057004
Abstract
The determination of oxygen levels in blood and other tissues in vivo is critical for ensuring proper body functioning, for monitoring the status of many diseases, such as cancer, and for predicting the efficacy of therapy. Here we demonstrate, for the first time, a lifetime-based photoacoustic technique for the measurement of oxygen in vivo, using an oxygen sensitive dye, enabling real time quantification of blood oxygenation. The results from the main artery in the rat tail indicated that the lifetime of the dye, quantified by the photoacoustic technique, showed a linear relationship with the blood oxygenation levels in the targeted artery.
© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE) 0091-3286/2012/$25.00 © 2012 SPIE
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Aniruddha Ray, Raoul Kopelman, Justin R. Rajian, Xueding Wang, and Yong-Eun K. Lee "Lifetime-based photoacoustic oxygen sensing in vivo," Journal of Biomedical Optics 17(5), 057004 (4 May 2012). https://doi.org/10.1117/1.JBO.17.5.057004
Published: 4 May 2012
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Cited by 40 scholarly publications and 1 patent.
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KEYWORDS
Oxygen
Photoacoustic spectroscopy
Blood
In vivo imaging
Tissues
Laser beam diagnostics
Absorption
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