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4 June 2012 Real-time photoacoustic imaging of prostate brachytherapy seeds using a clinical ultrasound system
Nathanael P. Kuo, Hyun Jae Kang, Danny Y. Song, Jin U. Kang, Emad M. Boctor
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Journal of Biomedical Optics, Vol. 17, Issue 6, 066005 (June 2012). https://doi.org/10.1117/1.JBO.17.6.066005
Abstract
Prostate brachytherapy is a popular prostate cancer treatment option that involves the permanent implantation of radioactive seeds into the prostate. However, contemporary brachytherapy procedure is limited by the lack of an imaging system that can provide real-time seed-position feedback. While many other imaging systems have been proposed, photoacoustic imaging has emerged as a potential ideal modality to address this need, since it could easily be incorporated into the current ultrasound system used in the operating room. We present such a photoacoustic imaging system built around a clinical ultrasound system to achieve the task of visualizing and localizing seeds. We performed several experiments to analyze the effects of various parameters on the appearance of brachytherapy seeds in photoacoustic images. We also imaged multiple seeds in an ex vivo dog prostate phantom to demonstrate the possibility of using this system in a clinical setting. Although still in its infancy, these initial results of a photoacoustic imaging system for the application of prostate brachytherapy seed localization are highly promising.
© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE) 0091-3286/2012/$25.00 © 2012 SPIE
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Nathanael P. Kuo, Hyun Jae Kang, Danny Y. Song, Jin U. Kang, and Emad M. Boctor "Real-time photoacoustic imaging of prostate brachytherapy seeds using a clinical ultrasound system," Journal of Biomedical Optics 17(6), 066005 (4 June 2012). https://doi.org/10.1117/1.JBO.17.6.066005
Received: 13 January 2012; Accepted: 5 April 2012; Published: 4 June 2012
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Cited by 31 scholarly publications and 2 patents.
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KEYWORDS
Prostate
Ultrasonography
Imaging systems
Photoacoustic imaging
Photoacoustic spectroscopy
Data acquisition
Signal to noise ratio
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