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9 July 2012 Out-of-plane Stokes imaging polarimeter for early skin cancer diagnosis
Pejhman Ghassemi, Paul Lemaillet, Jessica C. Ramella-Roman, Jeffrey W. Shupp M.D., Suraj S. Venna, Marc E. Boisvert M.D., Katherine Flanagan, Marion H. Jordan M.D., Thomas A. Germer
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Journal of Biomedical Optics, Vol. 17, Issue 7, 076014 (July 2012). https://doi.org/10.1117/1.JBO.17.7.076014
Abstract
Optimal treatment of skin cancer before it metastasizes critically depends on early diagnosis and treatment. Imaging spectroscopy and polarized remittance have been utilized in the past for diagnostic purposes, but valuable information can be also obtained from the analysis of skin roughness. For this purpose, we have developed an out-of-plane hemispherical Stokes imaging polarimeter designed to monitor potential skin neoplasia based on a roughness assessment of the epidermis. The system was utilized to study the rough surface scattering for wax samples and human skin. The scattering by rough skin-simulating phantoms showed behavior that is reasonably described by a facet scattering model. Clinical tests were conducted on patients grouped as follows: benign nevi, melanocytic nevus, melanoma, and normal skin. Images were captured and analyzed, and polarization properties are presented in terms of the principal angle of the polarization ellipse and the degree of polarization. In the former case, there is separation between different groups of patients for some incidence azimuth angles. In the latter, separation between different skin samples for various incidence azimuth angles is observed.
© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE) 0091-3286/2012/$25.00 © 2012 SPIE
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Pejhman Ghassemi, Paul Lemaillet, Jessica C. Ramella-Roman, Jeffrey W. Shupp M.D., Suraj S. Venna, Marc E. Boisvert M.D., Katherine Flanagan, Marion H. Jordan M.D., and Thomas A. Germer "Out-of-plane Stokes imaging polarimeter for early skin cancer diagnosis," Journal of Biomedical Optics 17(7), 076014 (9 July 2012). https://doi.org/10.1117/1.JBO.17.7.076014
Published: 9 July 2012
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Cited by 30 scholarly publications and 4 patents.
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KEYWORDS
Polarization
Scattering
Skin
Polarimetry
Light scattering
Melanoma
Skin cancer
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