Fluorescence spectra of blood and urine for cervical cancer detection

Vadivel Masilamani; Mohamad S. AlSalhi; Trinka Vijmasi; Kanaganaj Govindarajan; Ram Rathan Rai; Muhammad Atif; Saradh Prasad; Abdullah Aldwayyan

doi:10.1117/1.JBO.17.9.098001

6 September 2012 Fluorescence spectra of blood and urine for cervical cancer detection

Vadivel Masilamani, Mohamad S. AlSalhi, Trinka Vijmasi, Kanaganaj Govindarajan, Ram Rathan Rai, Muhammad Atif, Saradh Prasad, Abdullah Aldwayyan

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Journal of Biomedical Optics, Vol. 17, Issue 9, 098001 (September 2012). https://doi.org/10.1117/1.JBO.17.9.098001

Abstract

In the current study, the fluorescence emission spectra (FES) and Stokes shift spectra (SSS) of blood and urine samples of cervical cancer patients were obtained and compared to those of normal controls. Both spectra showed that the relative intensity of biomolecules such as porphyrin, collagen, Nicotinamide adenine dinucleotide, and flavin were quite out of proportion in cervical cancer patients. The biochemical mechanism for the elevation of these fluorophores is not yet definitive; nevertheless, these biomolecules could serve as tumor markers for diagnosis, screening, and follow-up of cervical cancers. To the best of our knowledge, this is the first report on FES and SSS of blood and urine of cervical cancer patients to give a sensitivity of 80% and specificity of 78%.

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Vadivel Masilamani, Mohamad S. AlSalhi, Trinka Vijmasi, Kanaganaj Govindarajan, Ram Rathan Rai, Muhammad Atif, Saradh Prasad, and Abdullah Aldwayyan "Fluorescence spectra of blood and urine for cervical cancer detection," Journal of Biomedical Optics 17(9), 098001 (6 September 2012). https://doi.org/10.1117/1.JBO.17.9.098001

Published: 6 September 2012

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