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22 November 2012 Imaging of biological tissues with pixel-level analysis of second-order susceptibility
Po-Sheng Hu, Ara Ghazaryan, Vladimir A. Hovhannisyan, Shean-Jen Chen, Yang-Fang Chen, Chang-Seok Kim, Tsung-Hua Tsai, Chen-Yuan Dong
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Journal of Biomedical Optics, Vol. 18, Issue 3, 031102 (November 2012). https://doi.org/10.1117/1.JBO.18.3.031102
Abstract
We discuss the recent advances in the development and applications of second-order susceptibility as a contrast mechanism in optical microscopy for biological tissues. We review nonlinear optical methods and approaches for differentiation of tissue structures and discrimination of normal and pathological skin tissues, which have been demonstrated for the potential use in clinical diagnosis. In addition, the potential of second-order susceptibility imaging, encompassing applications in differentiating various types of collagen molecules for clinical diagnosis, is demonstrated. Finally, we discuss future development and application of this technique.
© The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Po-Sheng Hu, Ara Ghazaryan, Vladimir A. Hovhannisyan, Shean-Jen Chen, Yang-Fang Chen, Chang-Seok Kim, Tsung-Hua Tsai, and Chen-Yuan Dong "Imaging of biological tissues with pixel-level analysis of second-order susceptibility," Journal of Biomedical Optics 18(3), 031102 (22 November 2012). https://doi.org/10.1117/1.JBO.18.3.031102
Published: 22 November 2012
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Cited by 12 scholarly publications.
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KEYWORDS
Second-harmonic generation
Tissues
Collagen
Microscopy
Biological research
Polarization
Skin
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