Combined two-photon microscopy and angiographic optical coherence tomography

Bumju Kim; Taejun Wang; Qingyun Li; Jutaek Nam; Sekyu Hwang; Euiheon Chung; Sungjee Kim; Ki Hean Kim

doi:10.1117/1.JBO.18.8.080502

7 August 2013 Combined two-photon microscopy and angiographic optical coherence tomography

Bumju Kim, Taejun Wang, Qingyun Li, Jutaek Nam, Sekyu Hwang, Euiheon Chung, Sungjee Kim, Ki Hean Kim

Author Affiliations +

Journal of Biomedical Optics, Vol. 18, Issue 8, 080502 (August 2013). https://doi.org/10.1117/1.JBO.18.8.080502

Abstract

A combined two-photon microscopy (TPM) and angiographic optical coherence tomography (OCT) is developed, which can provide molecular, cellular, structural, and vascular information of tissue specimens in vivo. This combined system is implemented by adding an OCT vasculature visualization method to the previous combined TPM and OCT, and then is applied to in vivo tissue imaging. Two animal models, a mouse brain cranial window model and a mouse ear cancer model, are used. Both molecular, cellular information at local regions of tissues, and structural, vascular information at relatively larger regions are visualized in the same sections. In vivo tissue microenvironments are better elucidated by the combined TPM and angiographic OCT.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Bumju Kim, Taejun Wang, Qingyun Li, Jutaek Nam, Sekyu Hwang, Euiheon Chung, Sungjee Kim, and Ki Hean Kim "Combined two-photon microscopy and angiographic optical coherence tomography," Journal of Biomedical Optics 18(8), 080502 (7 August 2013). https://doi.org/10.1117/1.JBO.18.8.080502

Published: 7 August 2013

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Cited by 6 scholarly publications.

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KEYWORDS

Optical coherence tomography

Angiography

Ear

Cancer

In vivo imaging

Tumor growth modeling

Animal model studies

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