Viscous optical clearing agent for in vivo optical imaging

Zijian Deng; Lijia Jing; Ning Wu; Pengyu lv; Xiaoyun Jiang; Qiushi Ren; Changhui Li

doi:10.1117/1.JBO.19.7.076019

28 July 2014 Viscous optical clearing agent for in vivo optical imaging

Zijian Deng, Lijia Jing, Ning Wu, Pengyu lv, Xiaoyun Jiang, Qiushi Ren, Changhui Li

Author Affiliations +

Journal of Biomedical Optics, Vol. 19, Issue 7, 076019 (July 2014). https://doi.org/10.1117/1.JBO.19.7.076019

Abstract

By allowing more photons to reach deeper tissue, the optical clearing agent (OCA) has gained increasing attention in various optical imaging modalities. However, commonly used OCAs have high fluidity, limiting their applications in in vivo studies with oblique, uneven, or moving surfaces. In this work, we reported an OCA with high viscosity. We measured the properties of this viscous OCA, and tested its successful performances in the imaging of a living animal’s skin with two optical imaging modalities: photoacoustic microscopy and optical coherence tomography. Our results demonstrated that the viscous OCA has a great potential in the study of different turbid tissues using various optical imaging modalities.

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Zijian Deng, Lijia Jing, Ning Wu, Pengyu lv, Xiaoyun Jiang, Qiushi Ren, and Changhui Li "Viscous optical clearing agent for in vivo optical imaging," Journal of Biomedical Optics 19(7), 076019 (28 July 2014). https://doi.org/10.1117/1.JBO.19.7.076019

Published: 28 July 2014

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