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19 February 2016 In vivo deep tissue imaging using wavefront shaping optical coherence tomography
Hyeonseung Yu, Peter Lee, KyeoReh Lee, Jaeduck Jang, Jaeguyn Lim, Wooyoung Jang, Yong Jeong, YongKeun Park
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Journal of Biomedical Optics, Vol. 21, Issue 10, 101406 (February 2016). https://doi.org/10.1117/1.JBO.21.10.101406
Abstract
Multiple light scattering in tissue limits the penetration of optical coherence tomography (OCT) imaging. Here, we present in vivo OCT imaging of a live mouse using wavefront shaping (WS) to enhance the penetration depth. A digital micromirror device was used in a spectral-domain OCT system for complex WS of an incident beam which resulted in the optimal delivery of light energy into deep tissue. Ex vivo imaging of chicken breasts and mouse ear tissues showed enhancements in the strength of the image signals and the penetration depth, and in vivo imaging of the tail of a live mouse provided a multilayered structure inside the tissue.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Hyeonseung Yu, Peter Lee, KyeoReh Lee, Jaeduck Jang, Jaeguyn Lim, Wooyoung Jang, Yong Jeong, and YongKeun Park "In vivo deep tissue imaging using wavefront shaping optical coherence tomography," Journal of Biomedical Optics 21(10), 101406 (19 February 2016). https://doi.org/10.1117/1.JBO.21.10.101406
Published: 19 February 2016
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Cited by 23 scholarly publications.
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KEYWORDS
Optical coherence tomography
Wavefronts
Tissues
In vivo imaging
Tissue optics
Image enhancement
Light scattering
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