Solid tissue simulating phantoms having absorption at 970 nm for diffuse optics

Gordon T. Kennedy; Griffin R. Lentsch; Brandon Trieu; Adrien Ponticorvo; Rolf B. Saager; Anthony J. Durkin

doi:10.1117/1.JBO.22.7.076013

20 July 2017 Solid tissue simulating phantoms having absorption at 970 nm for diffuse optics

Gordon T. Kennedy, Griffin R. Lentsch, Brandon Trieu, Adrien Ponticorvo, Rolf B. Saager, Anthony J. Durkin

Author Affiliations +

Journal of Biomedical Optics, Vol. 22, Issue 7, 076013 (July 2017). https://doi.org/10.1117/1.JBO.22.7.076013

Abstract

Tissue simulating phantoms can provide a valuable platform for quantitative evaluation of the performance of diffuse optical devices. While solid phantoms have been developed for applications related to characterizing exogenous fluorescence and intrinsic chromophores such as hemoglobin and melanin, we report the development of a poly(dimethylsiloxane) (PDMS) tissue phantom that mimics the spectral characteristics of tissue water. We have developed these phantoms to mimic different water fractions in tissue, with the purpose of testing new devices within the context of clinical applications such as burn wound triage. Compared to liquid phantoms, cured PDMS phantoms are easier to transport and use and have a longer usable life than gelatin-based phantoms. As silicone is hydrophobic, 9606 dye was used to mimic the optical absorption feature of water in the vicinity of 970 nm. Scattering properties are determined by adding titanium dioxide, which yields a wavelength-dependent scattering coefficient similar to that observed in tissue in the near-infrared. Phantom properties were characterized and validated using the techniques of inverse adding-doubling and spatial frequency domain imaging. Results presented here demonstrate that we can fabricate solid phantoms that can be used to simulate different water fractions.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Gordon T. Kennedy, Griffin R. Lentsch, Brandon Trieu, Adrien Ponticorvo, Rolf B. Saager, and Anthony J. Durkin "Solid tissue simulating phantoms having absorption at 970 nm for diffuse optics," Journal of Biomedical Optics 22(7), 076013 (20 July 2017). https://doi.org/10.1117/1.JBO.22.7.076013

Received: 9 June 2017; Accepted: 26 June 2017; Published: 20 July 2017

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