Metal-enhanced emission from indocyanine green: a new approach to in vivo imaging

Joanna B. Malicka; Ignacy Gryczynski; Chris D. Geddes; Joseph R. Lakowicz

doi:10.1117/1.1578643

1 July 2003 Metal-enhanced emission from indocyanine green: a new approach to in vivo imaging

Joanna B. Malicka, Ignacy Gryczynski, Chris D. Geddes, Joseph R. Lakowicz

Author Affiliations +

Journal of Biomedical Optics, Vol. 8, Issue 3, (July 2003). https://doi.org/10.1117/1.1578643

Indocyanine green (ICG) is widely used in medical imaging and testing. Its complex spectral behavior and low quantum yield limits some applications. We show that proximity of ICG to a metallic silver particle increases its intensity approximately 20-fold and decreases the decay time. Since the rate of photobleaching is not increased, our results suggest that ICG-silver particle complexes can yield at least 20-fold more photons per ICG molecule for improved medical imaging.

©(2003) Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation Download Citation

Joanna B. Malicka, Ignacy Gryczynski, Chris D. Geddes, and Joseph R. Lakowicz "Metal-enhanced emission from indocyanine green: a new approach to in vivo imaging," Journal of Biomedical Optics 8(3), (1 July 2003). https://doi.org/10.1117/1.1578643

Published: 1 July 2003

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
7 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY