Effect of target biological tissue and choice of light source on penetration depth and resolution in optical coherence tomography

Ann Sainter; Terence A. King; Mark Russell Dickinson

doi:10.1117/1.1628243

1 January 2004 Effect of target biological tissue and choice of light source on penetration depth and resolution in optical coherence tomography

Ann Sainter, Terence A. King, Mark Russell Dickinson

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Journal of Biomedical Optics, Vol. 9, Issue 1, (January 2004). https://doi.org/10.1117/1.1628243

The effectiveness of an optical coherence tomography (OCT) system depends largely on the light source chosen. Published data on the optical properties of tissues are used to quantify the exponential attenuation of broadband light on transport through tissue. The effective attenuation coefficient is taken to be the sum of the absorption and scattering coefficients. This is used to demonstrate the effect on the spectra of a wide range of published OCT sources and the change in system resolution induced, and hence to comment on the suitability of different sources for OCT. The tissues studied include skin dermis, liver, and gallbladder. Sources at higher wavelengths are shown to be capable of high-resolution OCT imaging at greater depths. Titanium:sapphire lasers would be most suited for high-resolution OCT over comparatively shallow depths into tissue. For lower-resolution applications of OCT, a semiconductor optical amplifier and ytterbium fiber sources have better powers and bandwidths than superluminescent diodes. The resolution of OCT systems is not reduced significantly with imaging depth.

©(2004) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Ann Sainter, Terence A. King, and Mark Russell Dickinson "Effect of target biological tissue and choice of light source on penetration depth and resolution in optical coherence tomography," Journal of Biomedical Optics 9(1), (1 January 2004). https://doi.org/10.1117/1.1628243

Published: 1 January 2004

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