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1 September 2004 Measuring red blood cell flow dynamics in a glass capillary using Doppler optical coherence tomography and Doppler amplitude optical coherence tomography
Julian Moger, Stephen John Matcher, C. Peter Winlove, Angela C. Shore
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Journal of Biomedical Optics, Vol. 9, Issue 5, (September 2004). https://doi.org/10.1117/1.1781163
Abstract
Blood, being a suspension of deformable red cells suspended in plasma, displays flow dynamics considerably more complicated than those of an ideal Newtonian fluid. Flow dynamics in blood capillaries of a few hundred micrometers in diameter are investigated using Doppler optical coherence tomography (DOCT) and Doppler amplitude optical coherence tomography (DAOCT), a novel extension of DOCT. Velocity profiles and concentration distributions of normal and rigidified in vitro red blood cell suspensions are shown to vary as functions of mean flow velocity, cell concentration, and cell rigidity. Deviation from the parabolic velocity profile expected for Pouseille flow is observed for both rigid and normal cells at low flow rates. Axial red cell migration both toward and away from the tube axis is observed for both rigid and normal cells as a function of flow velocity. Good agreement is found between our measurements, and theoretical expectations.
©(2004) Society of Photo-Optical Instrumentation Engineers (SPIE)
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Julian Moger, Stephen John Matcher, C. Peter Winlove, and Angela C. Shore "Measuring red blood cell flow dynamics in a glass capillary using Doppler optical coherence tomography and Doppler amplitude optical coherence tomography," Journal of Biomedical Optics 9(5), (1 September 2004). https://doi.org/10.1117/1.1781163
Published: 1 September 2004
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Cited by 39 scholarly publications and 1 patent.
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KEYWORDS
Blood
Particles
Capillaries
Optical coherence tomography
Doppler tomography
Optical spheres
Doppler effect
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