Prediction of reader estimates of mammographic density using convolutional neural networks

Georgia V. Ionescu; Martin Fergie; Michael Berks; Elaine F. Harkness; Johan Hulleman; Adam R. Brentnall; Jack Cuzick; D. Gareth Evans; Susan M. Astley

doi:10.1117/1.JMI.6.3.031405

31 January 2019 Prediction of reader estimates of mammographic density using convolutional neural networks

Georgia V. Ionescu, Martin Fergie, Michael Berks, Elaine F. Harkness, Johan Hulleman, Adam R. Brentnall, Jack Cuzick, D. Gareth Evans, Susan M. Astley

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Journal of Medical Imaging, Vol. 6, Issue 3, 031405 (January 2019). https://doi.org/10.1117/1.JMI.6.3.031405

Abstract

Mammographic density is an important risk factor for breast cancer. In recent research, percentage density assessed visually using visual analogue scales (VAS) showed stronger risk prediction than existing automated density measures, suggesting readers may recognize relevant image features not yet captured by hand-crafted algorithms. With deep learning, it may be possible to encapsulate this knowledge in an automatic method. We have built convolutional neural networks (CNN) to predict density VAS scores from full-field digital mammograms. The CNNs are trained using whole-image mammograms, each labeled with the average VAS score of two independent readers. Each CNN learns a mapping between mammographic appearance and VAS score so that at test time, they can predict VAS score for an unseen image. Networks were trained using 67,520 mammographic images from 16,968 women and for model selection we used a dataset of 73,128 images. Two case-control sets of contralateral mammograms of screen detected cancers and prior images of women with cancers detected subsequently, matched to controls on age, menopausal status, parity, HRT and BMI, were used for evaluating performance on breast cancer prediction. In the case-control sets, odd ratios of cancer in the highest versus lowest quintile of percentage density were 2.49 (95% CI: 1.59 to 3.96) for screen-detected cancers and 4.16 (2.53 to 6.82) for priors, with matched concordance indices of 0.587 (0.542 to 0.627) and 0.616 (0.578 to 0.655), respectively. There was no significant difference between reader VAS and predicted VAS for the prior test set (likelihood ratio chi square, p = 0.134). Our fully automated method shows promising results for cancer risk prediction and is comparable with human performance.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Georgia V. Ionescu, Martin Fergie, Michael Berks, Elaine F. Harkness, Johan Hulleman, Adam R. Brentnall, Jack Cuzick, D. Gareth Evans, and Susan M. Astley "Prediction of reader estimates of mammographic density using convolutional neural networks," Journal of Medical Imaging 6(3), 031405 (31 January 2019). https://doi.org/10.1117/1.JMI.6.3.031405

Received: 2 October 2018; Accepted: 17 December 2018; Published: 31 January 2019

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