KEYWORDS: Breast, Biopsy, Digital breast tomosynthesis, Monte Carlo methods, Biological research, X-rays, Sensors, Target acquisition, X-ray detectors, Dielectrophoresis
Stereotactic breast biopsy (SBB) is a common clinical procedure for suspicious breast lesion analysis. With the arrival of DBT-guided biopsy systems, the clinical performance of such procedures has improved enormously since breast lesions are better detected. However, little information is found in the literature regarding the patient’s radiation dose during these clinical procedures. This work presents, for the first time, a first approach to estimate the mean glandular dose (MGD) within the biopsy window for 101 patients who underwent breast biopsy in a commercially available DBT-guided prone table. This study is supported by the calculation of normalised glandular dose (DgN) coefficients from Monte Carlo simulations. Preliminary results show that the total MGD of the biopsy procedure varies between 10.2 mGy and 19.2 mGy for patients with breast thickness between 2 cm and 8 cm. Furthermore, a great variability in the number of acquisitions (tomo scan or stereo projections) of the biopsy procedure was observed. For the investigated system, MGD for DBT-guided breast biopsies are, for 5-6 cm thick breasts, around 23% lower than MGD observed in stereo biopsy procedures. The proposed method represents a first approach towards a full dose estimation of DBTguided breast biopsy procedures.
Geometric distortion is the inaccurate representation of the size or shape of a structure in the radiographic image. Exaggerated distortion makes radiography unacceptable for diagnosis. A new algorithm that was developed by us provides data on geometric distortion (GD) and ghost artifact-distortion (GAD) of digital breast tomosynthesis (DBT) images. This algorithm is similar to the one developed by the National Coordinating Centre for the Physics of Mammography (NCCPM), with the advantage of allowing the user to select the best-fit region of interest (ROI). The selection ensures that no information about the artifact dispersion contained in a ROI is lost. The aim of this study was to evaluate the dependence of ROI dimension (width and height) on the GD and GDA evaluation in digital breast tomosynthesis images using the new algorithm and to compare the results obtained with the limit values of reference, based on routine quality control tests for breast tomosynthesis. For the analyzes, the images were initially acquired with a 5 mm thick rectangular phantom composed of polymethyl methacrylate (PMMA) containing 1 mm diameter aluminum spheres. The phantom was inserted in the 60 mm thick PMMA phantom, positioned 25 mm away from the compression tray. The height of in-focus plane, the accuracy of positioning in the focus plane, and the appearance of aluminum spheres in the adjacent in-focus planes were analyzed for different ROI dimensions.
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