Detecting the efficacy of endotracheal tube suctioning in intubated ICU patients using in vivo catheter-based OCT  (Conference Presentation)

Roshan Dsouza; Darold R. Spillman Jr.; Ronit Barkalifa; Guillermo L. Monroy; Eric J. Chaney; Karen C. White; Stephen A. Boppart

doi:10.1117/12.2508022

7 March 2019 Detecting the efficacy of endotracheal tube suctioning in intubated ICU patients using in vivo catheter-based OCT (Conference Presentation)

Roshan Dsouza, Darold R. Spillman Jr., Ronit Barkalifa, Guillermo L. Monroy, Eric J. Chaney, Karen C. White, Stephen A. Boppart

Author Affiliations +

Proceedings Volume 10853, Optical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2019; 108530C (2019) https://doi.org/10.1117/12.2508022
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Mechanical ventilation is a critical intervention given to intensive care unit (ICU) patients who need airway support. However, this intervention with an endotracheal tube (ETT) is associated with complications such as ventilator-associated pneumonia (VAP). VAP is reported to develop within 48 hours after intubation and is associated with a mortality rate between 20 to 50%. The formation of bacterial biofilms within these ETT tubes provides a niche for infectious bacteria to become resistant to antibiotics. Suctioning of the ETT is believed to prevent airway colonization by pathogens, reduce resistance to airflow, and decrease biofilm formation. However, reports have shown that standard-of-care suctioning is not adequate to eliminate secretions from the ETT, and additional measures aiming to reduce the formation of ETT biofilms have been proposed to reduce VAP. We have recently demonstrated the use of catheter-based 3-D OCT imaging to identify the presence of in vivo biofilms within the ETTs of intubated human subjects in the ICU. In this study, we quantify the volume of mucus and biofilm in ETTs in intubated ICU patients using 3-D OCT, and define the efficacy of suctioning. Longitudinal OCT imaging was performed daily before and after suctioning at approximately 24-hour intervals until extubation. Extubated ETTs were subsequently imaged for further analysis. OCT image analysis results were correlated with clinical data and fluorescence microscopy/Gram stain images to verify the presence of bacteria and biofilm. In vivo catheter-based 3-D OCT offers the potential to rapidly determine the efficacy of ETT suctioning in order to effectively compare suctioning and brushing strategies in an effort to reduce the incidence of VAP.

Conference Presentation

Citation Download Citation

Roshan Dsouza, Darold R. Spillman Jr., Ronit Barkalifa, Guillermo L. Monroy, Eric J. Chaney, Karen C. White, and Stephen A. Boppart "Detecting the efficacy of endotracheal tube suctioning in intubated ICU patients using in vivo catheter-based OCT (Conference Presentation)", Proc. SPIE 10853, Optical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2019, 108530C (7 March 2019); https://doi.org/10.1117/12.2508022

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Optical coherence tomography

In vivo imaging

Bacteria

Image analysis

3D image processing

Human subjects

Luminescence

Show All Keywords

Keywords/Phrases

Search In:

Publication Years