Prof. Stephen A. Boppart Profile

Prof. Stephen A. Boppart

Full-Time Faculty Member at Beckman Institute for Advanced Science and Technology

SPIE Involvement:

Conference Program Committee | Author | Editor

Publications (199)

SPIE Journal Paper | 20 December 2024 Open Access

To label or not: the need for validation in label-free imaging

Joseph Szulczewski, Filiz Yesilkoy, Tyler Ulland, Randy Bartels, Bryan Millis, Stephen Boppart, Kevin Eliceiri

JBO, Vol. 29, Issue S2, S22717, (December 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.S2.S22717

KEYWORDS: Biological imaging, Biomedical optics, Imaging spectroscopy, Raman spectroscopy, Spectroscopy, Vibration, Autofluorescence, Fluorescence, Tissues, Nicotinamide adenine dinucleotide

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SPIE Journal Paper | 19 December 2024 Open Access

Introducing the Special Issue on Label-Free Quantitative Phase Imaging Honoring Prof. Gabriel Popescu, a Pioneer in Biomedical Optics

Stephen Boppart, Catherine Best-Popescu, Randy Bartels, Kevin Eliceiri

JBO, Vol. 29, Issue S2, S22701, (December 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.S2.S22701

KEYWORDS: Biomedical optics, Phase imaging, Biological imaging, Biomedical applications, Microscopy, Light emitting diodes, Tissues, Reflection, Optical imaging, Engineering

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SPIE Journal Paper | 25 March 2024 Open Access

Bichromatic tetraphasic full-field optical coherence microscopy

Rishyashring Iyer, Mantas Žurauskas, Yug Rao, Eric Chaney, Stephen Boppart

JBO, Vol. 29, Issue S2, S22704, (March 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.S2.S22704

KEYWORDS: Biological samples, Phase reconstruction, Optical coherence tomography, Scattering, Biological imaging, Optical coherence microscopy, Spectroscopy, Biomedical optics, Phase shifts, Beam splitters

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SPIE Journal Paper | 14 March 2024 Open Access

Compact simultaneous label-free autofluorescence multi-harmonic microscopy for user-friendly photodamage-monitored imaging

Geng Wang, Stephen Boppart, Haohua Tu

JBO, Vol. 29, Issue 03, 036501, (March 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.3.036501

KEYWORDS: Imaging systems, Pulse signals, Biomedical optics, Autofluorescence, Windows, Biological imaging, Signal to noise ratio, Sampling rates, Tissues, Laser sources

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Proceedings Article | 13 March 2024 Presentation

Early selection of desired biopharmaceutical CHO cell lines using label-free multimodal optical microscopy and machine learning

Jindou Shi, Alexander Ho, Eric Chaney, Janet Sorrells, Kevin Tan, Aneesh Alex, Remben Talaban, Darold Spillman, Marina Marjanovic, Minh Doan, Steve Hood, Stephen Boppart

Proceedings Volume PC12846, PC1284603 (2024) https://doi.org/10.1117/12.3001298

KEYWORDS: Optical microscopy, Machine learning, Multiphoton fluorescence microscopy, Fluorescence lifetime imaging, Profiling, Ovary, Multiphoton microscopy, Multimodal imaging, Monte Carlo methods, Manufacturing

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Proceedings Article | 13 March 2024 Presentation

Dispersion compensation technique for evident chromatic anomalies in ultrafast optical interferometry

Rishyashring Iyer, Lingxiao Yang, Janet Sorrells, Stephen Boppart

Proceedings Volume PC12875, PC1287502 (2024) https://doi.org/10.1117/12.3000646

KEYWORDS: Ultrafast phenomena, Optical interferometry, Colorimetry, Optical coherence tomography, Ultrafast imaging, Quantum interferometry, Multiphoton microscopy, Reconstruction algorithms, Phase shift keying, Biomedical applications

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Proceedings Article | 13 March 2024 Presentation

Bichromatic tetraphasic optical coherence microscopy for full-field single-shot imaging of biological dynamics

Rishyashring Iyer, Mantas Žurauskas, Eric Chaney, Stephen Boppart

Proceedings Volume PC12830, PC1283025 (2024) https://doi.org/10.1117/12.3000645

KEYWORDS: Biological imaging, Optical coherence microscopy, Phase shifts, Wave plates, Tumors, Tissues, Tissue optics, Spectroscopy, Speckle, Spatial resolution

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Proceedings Article | 13 March 2024 Presentation

Attention-based weakly-supervised deep learning for the identification and localization of drug fingerprints based on label-free hyperspectral CARS microscopy

Jindou Shi, Kajari Bera, Prabuddha Mukherjee, Aneesh Alex, Eric Chaney, Bradley Spencer-Dene, Jan Majer, Marina Marjanovic, Darold Spillman, Steve Hood, Stephen Boppart

Proceedings Volume PC12821, PC1282106 (2024) https://doi.org/10.1117/12.3001269

KEYWORDS: Microscopy, Deep learning, Biological samples, Nervous system, Complex systems, Vibration, Spatial learning, Profiling, Optical imaging, Nondestructive evaluation

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Proceedings Article | 13 March 2024 Presentation

Probing magnetic field effects on cellular redox state using autofluorescence intensity and lifetime microscopy

Kevin Tan, Carlos Renteria, Rishyashring Iyer, Alexander Ho, Janet Sorrells, Robert Usselman, Stephen Boppart

Proceedings Volume PC12863, PC1286306 (2024) https://doi.org/10.1117/12.3003226

KEYWORDS: Magnetism, Autofluorescence, Imaging systems, Microscopy, Modulation, Quantum fields, Quantum effects, Biological imaging, Visualization, Tissues

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Proceedings Article | 13 March 2024 Presentation

Prognostic value of optical coherence tomography (OCT) with machine learning for assessing clinical outcomes of otitis media

Alexander Ho, Qian Jiang, Katherine Peterson, Roxanne Link, Guillermo Monroy, Darold Spillman, Edita Aksamitiene, Joseph Kerschner, Stephen Boppart, Minh Do

Proceedings Volume PC12818, (2024) https://doi.org/10.1117/12.3003143

KEYWORDS: Optical coherence tomography, Machine learning, Biofilms, Visual process modeling, Tissues, Diseases and disorders, Visualization, Video, Scattering, Image resolution

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Proceedings Article | 13 March 2024 Presentation

Academia to industry translation of SLAM technology

Aneesh Alex, Kayvan Tehrani, Mantas Zurauskas, Matthew Durack, Reid Groseclose, Steve Hood, Stephen Boppart

Proceedings Volume PC12821, PC128210B (2024) https://doi.org/10.1117/12.3003121

KEYWORDS: Industry, Microscopy, Microscopes, Image analysis, Biological research, Autofluorescence, Analytical research, 3D modeling, Visualization, Visual process modeling

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Proceedings Article | 13 March 2024 Presentation

Predicting productivity in CHO cells based on co-occurrence of metabolism-related features in simultaneous label-free autofluorescence multiharmonic (SLAM) microscopy

Alexander Ho, Jindou Shi, Eric Chaney, Janet Sorrells, Kevin Tan, Aneesh Alex, Remben Talaban, Darold Spillman, Marina Marjanovic, Minh Doan, Steve Hood, Stephen Boppart

Proceedings Volume PC12854, PC1285407 (2024) https://doi.org/10.1117/12.3003094

KEYWORDS: Microscopy, Fluorescence lifetime imaging, Autofluorescence, Feature extraction, Support vector machines, Second harmonic generation, Proteins, Ovary, Multimodal imaging, Monte Carlo methods

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Proceedings Article | 13 March 2024 Presentation

Robust supercontinuum generation using an yttrium aluminum garnet crystal for multimodal label-free multiphoton microscopy

Alejandro De la Cadena, Jaena Park, Kayvan Forouhesh Tehrani, Carlos Renteria, Guillermo Monroy, Stephen Boppart

Proceedings Volume PC12854, PC128540N (2024) https://doi.org/10.1117/12.3002654

KEYWORDS: YAG lasers, Supercontinuum generation, Multiphoton microscopy, Crystals, Nonlinear crystals, Microscopes, Tissues, Photonic crystals, Laser radiation, Radiotherapy

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Proceedings Article | 13 March 2024 Presentation

Imaging middle ear tissues with biofilms and cholesteatoma using polarization-sensitive swept-source optical coherence tomography

Adam Markowicz, Rishyashring Iyer, Kavya Sudhir, Guillermo Monroy, Darold Spillman, Stephen Boppart

Proceedings Volume PC12818, (2024) https://doi.org/10.1117/12.3001909

KEYWORDS: Biofilms, Ear, Tissues, Optical coherence tomography, Pathology, Birefringence, Portability, Polarization, In vivo imaging, In vitro testing

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Proceedings Article | 13 March 2024 Presentation

Pixelation with concentration-encoded effective photons for molecular optical sectioning microscopy

Geng Wang, Rishyashring Iyer, Janet Sorrells, Edita Aksamitiene, Eric Chaney, Carlos Renteria, Jaena Park, Jindou Shi, Yi Sun, Stephen Boppart, Haohua Tu

Proceedings Volume PC12836, PC128360H (2024) https://doi.org/10.1117/12.3001809

KEYWORDS: Photons, Optical microscopy, Multiphoton fluorescence microscopy, Microscopy, Reproducibility, Fluorescence microscopy, Fluorescence, Second harmonic generation, Reliability, Quality control

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Proceedings Article | 13 March 2024 Presentation

Label-free polarimetric multimodal optical imaging of collagen

Lingxiao Yang, Rishyashring Iyer, Janet Sorrells, Eric Chaney, Stephen Boppart

Proceedings Volume PC12834, PC1283402 (2024) https://doi.org/10.1117/12.3001241

KEYWORDS: Collagen, Optical imaging, Tissues, Second harmonic generation, Polarimetry, Polarization, Microscopy, Imaging systems, Biological imaging, Visualization

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Proceedings Article | 13 March 2024 Presentation

Multiphoton imaging and control of melanopsin activation in living cellular systems by spectral-temporal modulation of a supercontinuum source

Carlos Renteria, Jiho Kahng, Brian Tibble, Rishyashring Iyer, Kayvan Tehrani, Yuan-Zhi Liu, Stephen Boppart

Proceedings Volume PC12863, PC1286308 (2024) https://doi.org/10.1117/12.3001042

KEYWORDS: Calcium, In vitro testing, Absorption, Retina, Ultrafast phenomena, Ultrafast lasers, Ultrafast laser spectroscopy, Spectroscopy, Pulse signals, Phase shift keying

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Proceedings Article | 13 March 2024 Poster

Self-supervised deep learning enables robust fluorescence lifetime estimation with limited photons

Jindou Shi, Alexander Ho, Kevin Tan, Janet Sorrells, Rishyashring Iyer, Eric Chaney, Darold Spillman, Marina Marjanovic, Stephen Boppart

Proceedings Volume PC12857, PC1285719 (2024) https://doi.org/10.1117/12.3001312

KEYWORDS: Fluorescence lifetime imaging, Photons, Fluorescence, Deep learning, Statistical analysis, Education and training, Biological research, Reliability, Molecular interactions, Microscopy

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Proceedings Article | 12 March 2024 Paper

VAMPIRE microscopy enables fast and simultaneous structural, metabolic, and chemical characterization of living tissues label-free

Rishyashring Iyer, Janet Sorrells, Lingxiao Yang, Eric Chaney, Stephen Boppart

Proceedings Volume 12847, 128470B (2024) https://doi.org/10.1117/12.3000644

KEYWORDS: Microscopy, Fluorescence lifetime imaging, Biological imaging, Second harmonic generation, Fluorescence, Signal detection, Birefringence, Raman scattering, Optical coherence microscopy, Signal processing for photon counting, Computational imaging

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Proceedings Article | 25 April 2023 Poster + Paper

Fast fluorescence lifetime imaging microscopy using single- and multi-photon peak event detection for rapid quantification of NAD(P)H-related metabolic dynamics during apoptosis

Janet Sorrells, Marina Marjanovic, Rishyashring Iyer, Lingxiao Yang, Eric Chaney, Geng Wang, Haohua Tu, Stephen Boppart

Proceedings Volume 12384, 123840N (2023) https://doi.org/10.1117/12.2648963

KEYWORDS: Tumors, Cell death, In vivo imaging, Fluorescence lifetime imaging, Fluorescence intensity, Photon counting, Fluorescence, Time correlated single photon counting, In vitro testing, Single photon detectors

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Proceedings Article | 17 March 2023 Presentation

Versatile phase and amplitude pulse shaping using 2D spatial light modulator for spectrally optimized multimodal optical imaging

Lingxiao Yang, Rishyashring Iyer, Janet Sorrells, Carlos Renteria, Kayvan Tehrani, Darold Spillman, Stephen Boppart

Proceedings Volume PC12411, PC1241102 (2023) https://doi.org/10.1117/12.2647608

KEYWORDS: Pulse shaping, Optical imaging, Spatial light modulators, Phase shift keying, Optical coherence tomography, Raman spectroscopy, Phase modulation, Amplitude modulation, Ultrafast laser spectroscopy, Supercontinuum sources

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Proceedings Article | 17 March 2023 Presentation

Speciation of otitis media causing bacterial biofilms using texture analysis features from OCT images

Farzana Zaki, Kavya Sudhir, Guillermo Monroy, Jindou Shi, Stephen Boppart

Proceedings Volume 12354, 1235403 (2023) https://doi.org/10.1117/12.2647878

KEYWORDS: Optical coherence tomography, Biological research, Ear, In vitro testing, Image analysis, Principal component analysis, In vivo imaging, Feature extraction, Binary data

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Proceedings Article | 17 March 2023 Presentation

All-optical neurophysiology using superfast polarization-sensitive off-axis full-field optical coherence microscopy (SPoOF OCM) at kilohertz frame rates

Rishyashring Iyer, Carlos Renteria, Jiho Kahng, Stephen Boppart

Proceedings Volume PC12365, PC123650F (2023) https://doi.org/10.1117/12.2649258

KEYWORDS: Neurophysiology, Optical coherence microscopy, Optogenetics, Neurons, Optical imaging, Statistical analysis, Proteins, Neuroscience, Luminescence, Image resolution

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Proceedings Article | 17 March 2023 Presentation

Integrated Raman spectroscopy and optical coherence tomography system for characterizing otitis media

Guillermo Monroy, Sean Fitzgerald, Andrea Locke, Jungeun Won, Darold Spillman, Alexander Ho, Farzana Zaki, Honggu Choi, Eric Chaney, Jay Werkhaven, Kevin Mason, Anita Mahadevan-Jansen, Stephen Boppart

Proceedings Volume 12354, 1235404 (2023) https://doi.org/10.1117/12.2648504

KEYWORDS: Optical coherence tomography, Ear, Raman spectroscopy, Remote sensing, Visualization, Prototyping, In vitro testing, Human subjects, Diagnostics, Bone

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Proceedings Article | 17 March 2023 Presentation

Label-free identification of Alzheimer’s disease plaques using multiple co-registered nonlinear optical biomarkers

Kayvan Tehrani, Jaena Park, Carlos Renteria, Stephen Boppart

Proceedings Volume 12364, 1236405 (2023) https://doi.org/10.1117/12.2648013

KEYWORDS: Alzheimer's disease, Proteins, Microscopy, Harmonic generation, Brain, Analytical research, Visualization, Tissues, Second-harmonic generation, Raman spectroscopy

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Proceedings Article | 17 March 2023 Presentation

Microplasma exposure as a novel therapeutic treatment for otitis media demonstrated in a pre-clinical chinchilla model

Guillermo Monroy, Jinhong Kim, Alexander Ho, Andrey Mironov, Farzana Zaki, Darold Spillman, Gabrielle Choo-Kang, Jungeun Won, Peter Sun, Edita Aksamitiene, Marina Marjanovic, Eric Chaney, Thanh Huong Nguyen, J. Gary Eden, Stephen Boppart

Proceedings Volume PC12358, PC1235809 (2023) https://doi.org/10.1117/12.2648469

KEYWORDS: Ear, Chemical mechanical planarization, Optical coherence tomography, In vitro testing, Injuries, Animal model studies, Tissues, Resistance, Medicine, Instrument modeling

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Proceedings Article | 17 March 2023 Presentation

Imaging and assessment of human ear wax with optical coherence tomography

Alexander Ho, Guillermo Monroy, Edita Aksamitiene, Darold Spillman, Marina Marjanovic, Stephen Boppart

Proceedings Volume 12354, 1235402 (2023) https://doi.org/10.1117/12.2649235

KEYWORDS: Optical coherence tomography, Ear, Image segmentation, Signal attenuation, Proteins, Product engineering, Medicine, Imaging systems, Human subjects, Fungi

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Proceedings Article | 17 March 2023 Presentation

Visualizing and quantifying cisplatin-induced nephrotoxicity using nonlinear optical imaging

Aneesh Alex, Eric Chaney, Crysthiane Ishiy, Ciarán Fisher, Darold Spillman, Marina Marjanovic, Jan Roger, Reid Groseclose, Steve Hood, Stephen Boppart

Proceedings Volume 12357, 1235705 (2023) https://doi.org/10.1117/12.2649232

KEYWORDS: Visualization, Optical imaging, Tissue optics, Luminescence, Harmonic generation, Second-harmonic generation, Multiphoton microscopy, Microscopy, Medicine, Kidney

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Proceedings Article | 17 March 2023 Presentation

Fast label-free multiphoton fluorescence lifetime imaging microscopy for metabolic characterization of the skin microbiome

Janet Sorrells, Rishyashring Iyer, Lingxiao Yang, Farzana Zaki, Eric Chaney, Marina Marjanovic, Stephen Boppart

Proceedings Volume PC12358, PC1235802 (2023) https://doi.org/10.1117/12.2648984

KEYWORDS: Multiphoton fluorescence microscopy, Skin, Multiphoton microscopy, Microscopy, Bacteria, Photon counting, Mode conditioning cables, Algorithm development, Single photon detectors, Single photon

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Proceedings Article | 16 March 2023 Presentation

Fewer photons for fast FLIM using analog multiplexing of laser clock (Conference Presentation)

Rishyashring Iyer, Janet Sorrells, Geng Wang, Lingxiao Yang, Haohua Tu, Stephen Boppart

Proceedings Volume PC12390, PC123900S (2023) https://doi.org/10.1117/12.2649178

KEYWORDS: Fluorescence lifetime imaging, Microscopy, Photon counting, Photons, Clocks, Multiplexing, Analog electronics, Single photon detectors, Electronics

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Proceedings Article | 16 March 2023 Presentation

High signal-to-noise ratio rapid third-order label-free and harmonic generation microscopy of neural dynamics through electronic heterodyne amplification (Conference Presentation)

Kayvan Tehrani, Alejandro De la Cadena, Stephen Boppart

Proceedings Volume PC12390, PC1239009 (2023) https://doi.org/10.1117/12.2648069

KEYWORDS: Signal to noise ratio, Microscopy, Heterodyning, Harmonic generation, Tissues, Signal processing, Interference (communication), In vivo imaging, Ultrafast lasers, Tissue optics

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Proceedings Article | 16 March 2023 Presentation

Label-free optophysiology of neural activity using dual-channel fast autofluorescence lifetime imaging microscopy (Conference Presentation)

Rishyashring Iyer, Janet Sorrells, Carlos Renteria, Lingxiao Yang, Jiho Kahng, Stephen Boppart

Proceedings Volume PC12391, PC1239106 (2023) https://doi.org/10.1117/12.2649251

KEYWORDS: Microscopy, Photon counting, Field programmable gate arrays, Neurons, Signal to noise ratio, Parallel processing, Neurophysiology, Luminescence, Chemical analysis, Fluorescence lifetime imaging

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Proceedings Article | 15 March 2023 Presentation

Characterization of Chinese hamster ovary (CHO) cell lines by simultaneous label-free autofluorescence multi-harmonic (SLAM) microscopy for upstream bioprocessing (Conference Presentation)

Alexander Ho, Jindou Shi, Eric Chaney, Corey Snyder, Aneesh Alex, Remben Talaban, Janet Sorrells, Darold Spillman, Marina Marjanovic, Steve Hood, Stephen Boppart

Proceedings Volume PC12383, PC1238302 (2023) https://doi.org/10.1117/12.2646378

KEYWORDS: Microscopy, Ovary, Image processing, Luminescence, Image segmentation, Third-harmonic generation, Second-harmonic generation, Proteins, Multimodal imaging, Manufacturing

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Proceedings Article | 6 March 2023 Presentation

Characterizing metabolic signatures of human biofluid-derived extracellular vesicles using label-free multimodal nonlinear optical microscopy

Janet Sorrells, Jaena Park, Edita Aksamitiene, Elisabeth Martin, Eric Chaney, Marina Marjanovic, Anna Higham, Kimberly Cradock, Zheng Liu, Stephen Boppart

Proceedings Volume PC12373, PC123730B (2023) https://doi.org/10.1117/12.2648976

KEYWORDS: Optical microscopy, Microscopy, Breast cancer, Surgery, Multiphoton microscopy, Diagnostics, Cancer, Tissues, Tissue optics, Statistical analysis

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Proceedings Article | 6 March 2023 Presentation

Photon counting with analog photodetection for high-signal-rate quantitative nonlinear microscopy

Geng Wang, Janet Sorrells, Rishyashring Iyer, Stephen A. Boppart, Haohua Tu

Proceedings Volume PC12370, PC1237006 (2023) https://doi.org/10.1117/12.2648438

KEYWORDS: Photon counting, Analog electronics, Photodetectors, Microscopy, Imaging systems, Photomultipliers, Optical microscopy, Oncology, Neuroscience, Medical research

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Proceedings Article | 6 March 2023 Presentation

Nonlinear imaging histopathology: a method to correlate the gold-standard hematoxylin and eosin staining with modern nonlinear microcopy

Kayvan Tehrani, Jaena Park, Eric Chaney, Haohua Tu, Stephen Boppart

Proceedings Volume PC12368, PC123680C (2023) https://doi.org/10.1117/12.2648062

KEYWORDS: Tissues, Microscopy, Laser ablation, Multilayers, Laser marking, Gold, Femtosecond phenomena, Cancer

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SPIE Journal Paper | 28 May 2022 Open Access

Label-free multimodal nonlinear optical imaging of needle biopsy cores for intraoperative cancer diagnosis

Lingxiao Yang, Jaena Park, Eric Chaney, Janet Sorrells, Marina Marjanovic, Heidi Phillips, Darold Spillman, Stephen Boppart

JBO, Vol. 27, Issue 05, 056504, (May 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.5.056504

KEYWORDS: Tissues, Tumors, Imaging systems, Liver, Biopsy, Tissue optics, Second-harmonic generation, Cancer, Optical imaging, Multimodal imaging

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Significance: Needle biopsy (NB) procedures are important for the initial diagnosis of many types of cancer. However, the possibility of NB specimens being unable to provide diagnostic information, (i.e., non-diagnostic sampling) and the time-consuming histological evaluation process can cause delays in diagnoses that affect patient care. Aim: We aim to demonstrate the advantages of this label-free multimodal nonlinear optical imaging (NLOI) technique as a non-destructive point-of-procedure evaluation method for NB tissue cores, for the visualization and characterization of the tissue microenvironment. Approach: A portable, label-free, multimodal NLOI system combined second-harmonic generation (SHG) and third-harmonic generation and two- and three-photon autofluorescence (2PF, 3PF) microscopy. It was used for intraoperative imaging of fresh NB tissue cores acquired during canine cancer surgeries, which involved liver, lung, and mammary tumors as well as soft-tissue sarcoma; in total, eight canine patients were recruited. An added tissue culture chamber enabled the use of this NLOI system for longitudinal imaging of fresh NB tissue cores taken from an induced rat mammary tumor and healthy mouse livers. Results: The intraoperative NLOI system was used to assess fresh canine NB specimens during veterinary cancer surgeries. Histology-like morphological features were visualized by the combination of four NLOI modalities at the point-of-procedure. The NLOI results provided quantitative information on the tissue microenvironment such as the collagen fiber orientation using Fourier-domain SHG analysis and metabolic profiling by optical redox ratio (ORR) defined by 2PF/(2PF + 3PF). The analyses showed that the canine mammary tumor had more randomly oriented collagen fibers compared to the tumor margin, and hepatocarcinoma had a wider distribution of ORR with a lower mean value compared to the liver fibrosis and the normal-appearing liver. Moreover, the loss of metabolic information during tissue degradation of fresh murine NB specimens was shown by overall intensity decreases in all channels and an increase of mean ORR from 0.94 (standard deviation 0.099) to 0.97 (standard deviation 0.077) during 1-h longitudinal imaging of a rat mammary tumor NB specimen. The tissue response to staurosporine (STS), an apoptotic inducer, from fresh murine liver NB specimens was also observed. The mean ORR decreased from 0.86 to 0.74 in the first 40 min and then increased to 0.8 during the rest of the hour of imaging, compared to the imaging results without the addition of STS, which showed a continuous increase of ORR from 0.72 to 0.75. Conclusions: A label-free, multimodal NLOI platform reveals microstructural and metabolic information of the fresh NB cores during intraoperative cancer imaging. This system has been demonstrated on animal models to show its potential to provide a more comprehensive histological assessment and a better understanding of the unperturbed tumor microenvironment. Considering tissue degradation, or loss of viability upon fixation, this intraoperative NLOI system has the advantage of immediate assessment of freshly excised tissue specimens at the point of procedure.

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Proceedings Article | 28 April 2022 Presentation

Neuronal activation and ballistic cellular dynamics by phase-sensitive optical coherence microscopy

Honggu Choi, Rishyashring Iyer, Carlos Renteria, Brian Tibble, Mantas Žurauskas, Stephen Boppart

Proceedings Volume PC11946, PC119460E (2022) https://doi.org/10.1117/12.2609753

KEYWORDS: Optical coherence microscopy, Neurons, Diffusion, Signal to noise ratio, Ion exchange

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Proceedings Article | 9 March 2022 Presentation

Explainable weakly-supervised learning for optical biomarker discovery in multiphoton virtual histology

Jindou Shi, Haohua Tu, Jaena Park, Stephen Boppart

Proceedings Volume PC12019, PC1201905 (2022) https://doi.org/10.1117/12.2608769

KEYWORDS: Tumors, Tumor growth modeling, Breast cancer, Biomedical optics, Neural networks, Microscopy, Eye, Excel, Data modeling, Collagen

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Proceedings Article | 7 March 2022 Presentation + Paper

FreeView: a portable multiphoton imaging system for multimodal high-data-content label-free imaging

Mantas Žurauskas, Matthew Durack, Haohua Tu, Stephen Boppart

Proceedings Volume 11949, 1194907 (2022) https://doi.org/10.1117/12.2607377

KEYWORDS: Imaging systems, Tissues, Multimodal imaging, Microscopy, Signal detection, Multichannel imaging systems, Harmonic generation, Prototyping, Data modeling, Tissue optics

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Proceedings Article | 7 March 2022 Presentation

Computational single-photon counting for fast fluorescence lifetime imaging microscopy using single- and multi-photon peak event detection

Janet Sorrells, Rishyashring Iyer, Lingxiao Yang, Eric Chaney, Marina Marjanovic, Haohua Tu, Stephen Boppart

Proceedings Volume PC11965, PC119650D (2022) https://doi.org/10.1117/12.2607777

KEYWORDS: Fluorescence lifetime imaging, Single photon detectors, Photon counting, Multiphoton microscopy, Multiphoton fluorescence microscopy, Microscopy, Analog electronics, Sensors, Detection and tracking algorithms, Confocal microscopy

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Proceedings Article | 7 March 2022 Presentation

Phase- and polarization-sensitive full-field optical coherence microscopy for label-free imaging of millisecond scale neural activity

Rishyashring Iyer, Yuan-Zhi Liu, Honggu Choi, Carlos Renteria, Brian Tibble, Stephen Boppart

Proceedings Volume PC11948, PC1194807 (2022) https://doi.org/10.1117/12.2609374

KEYWORDS: Optical coherence microscopy, Electrophysiology, Neurophysiology, Neurons, Microscopy, Luminescence, Ions, Birefringence

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Proceedings Article | 7 March 2022 Presentation

Label free and non-destructive imaging approach for cell line selection of genetically modified functional Chinese Hamster Ovary (CHO) Cells

Prabuddha Mukherjee, Edita Aksamitiene, Aneesh Alex, Jindou Shi, Eric Chaney, Remben Talaban, Maire Daly, Darold Spillman, Marina Marjanovic, Gary Finka, Steve Hood, Stephen Boppart

Proceedings Volume PC11964, PC119640C (2022) https://doi.org/10.1117/12.2608764

KEYWORDS: Ovary, Nondestructive evaluation, Fluorescence lifetime imaging, Optical imaging, Mode conditioning cables, Microscopy, Luminescence, Image analysis, Genetics, Cell biology

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Proceedings Article | 7 March 2022 Presentation

Differential uptake of antisense oligonucleotides in mouse hepatocytes and macrophages revealed by simultaneous 2P-fluorescence and coherent Raman imaging

Prabuddha Mukherjee, Edita Aksamitiene, Aneesh Alex, Jindou Shi, Kajari Bera, Chi Zhang, Darold Spillman, Marina Marjanovic, Michael Fazio, Punit Seth, Kendall Frazier, Steve Hood, Stephen Boppart

Proceedings Volume PC11938, PC119380D (2022) https://doi.org/10.1117/12.2608740

KEYWORDS: Coherence imaging, Luminescence, Raman spectroscopy, Liver, Receptors, Two photon imaging, Tissues, Multimodal imaging, Molecules, Modulation

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Proceedings Article | 7 March 2022 Presentation

Non-invasive detection and characterization of otitis media causing bacteria and bacterial biofilms through Raman spectroscopy and optical coherence tomography

Farzana Zaki, Andrea Locke, Sean Fitzgerald, Kavya Sudhir, Guillermo Monroy, Honggu Choi, Jungeun Won, Stephen Boppart, Anita Mahadevan-Jansen

Proceedings Volume PC11935, PC1193502 (2022) https://doi.org/10.1117/12.2608410

KEYWORDS: Optical coherence tomography, Raman spectroscopy, Bacteria, Ear, Remote sensing, Diagnostics, Spectroscopy, Resistance, Refractive index, Real time imaging

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Proceedings Article | 7 March 2022 Presentation

Monitoring the delivery of lipid nanoparticle encapsulated self-amplifying mRNA vaccine using coherent Raman microscopy and multiphoton imaging

Kajari Bera, Prabuddha Mukherjee, Edita Aksamitiene, Aneesh Alex, Jindou Shi, Darold Spillman, Marina Marjanovic, Ahmed Shabana, Russell Johnson, Steve Hood, Stephen Boppart

Proceedings Volume PC11938, PC119380A (2022) https://doi.org/10.1117/12.2609087

KEYWORDS: Multiphoton microscopy, Microscopy, Nanoparticles, Raman spectroscopy, Green fluorescent protein, CARS tomography, Multiphoton fluorescence microscopy, Luminescence, Proteins, Multimodal imaging

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Proceedings Article | 7 March 2022 Presentation

Ultra-parallel label-free optophysiology of dynamic neural activity and circuit connectivity

Stephen Boppart

Proceedings Volume PC11944, PC119440E (2022) https://doi.org/10.1117/12.2617168

KEYWORDS: Electrophysiology, Neurophysiology, Neurons, Microscopy, Luminescence, Ions, Birefringence, Optical coherence microscopy

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Proceedings Article | 7 March 2022 Presentation

User-friendly photodamage-monitored imaging by simultaneous label-free autofluorescence multiharmonic (SLAM) microscopy

Geng Wang, Rishyashring Iyer, Janet Sorrells, Kayvan Tehrani, Kajari Bera, Eric Chaney, Haohua Tu, Stephen Boppart

Proceedings Volume PC11954, PC1195404 (2022) https://doi.org/10.1117/12.2608849

KEYWORDS: Microscopy, Signal to noise ratio, Imaging systems, Optical microscopy, Image resolution, Image processing, Ultrafast phenomena, Tissues, Signal attenuation, Photonic crystal fibers

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Proceedings Article | 7 March 2022 Presentation

AI-assisted simultaneous label-free autofluorescence multiharmonic (SLAM) microscopy for the discovery of human breast cancer-related optical biomarkers

Jindou Shi, Haohua Tu, Jaena Park, Stephen Boppart

Proceedings Volume PC11952, PC1195205 (2022) https://doi.org/10.1117/12.2608857

KEYWORDS: Microscopy, Breast, Tissue optics, Tumors, Breast cancer, Tumor growth modeling, Tissues, Reliability, Profiling, Optical microscopy

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Proceedings Article | 7 March 2022 Presentation

Nanodiamond based phantom for assessing multimodal fluorescence and multiharmonic imaging systems

Mantas Žurauskas, Aneesh Alex, Jaena Park, Steve Hood, Stephen Boppart

Proceedings Volume PC11951, PC1195103 (2022) https://doi.org/10.1117/12.2608258

KEYWORDS: Imaging systems, Luminescence, Microscopy, Control systems, Calibration, Microscopes, Harmonic generation, Scattering, Quality systems, Optical instrument design

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Proceedings Article | 7 March 2022 Presentation

Photon budget analysis for label-free quantitative multiphoton microscopy

Rishyashring Iyer, Janet Sorrells, Geng Wang, Lingxiao Yang, Haohua Tu, Stephen Boppart

Proceedings Volume PC11951, PC119510I (2022) https://doi.org/10.1117/12.2609392

KEYWORDS: Multiphoton microscopy, Photonic microstructures, Luminescence, Biological research, Tissues, Stochastic processes, Statistical analysis, Sensors, Photodetectors, In vitro testing

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Proceedings Article | 2 March 2022 Presentation

Label-free multi-photon super-resolution microscopy by multiplexed single point spread function image acquisition

Kayvan Forouhesh Tehrani, Stephen Boppart

Proceedings Volume PC11966, PC119660B (2022) https://doi.org/10.1117/12.2607832

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Proceedings Article | 2 March 2022 Presentation

Label-free imaging and optical biomarker discovery in the tumor and tissue microenvironment with SLAM microscopy

Stephen Boppart

Proceedings Volume PC11972, PC119720E (2022) https://doi.org/10.1117/12.2607166

KEYWORDS: Tissue optics, Tumors, Optical imaging, Microscopy, Biomedical optics, Cancer, Visualization, Tissues, Surgery, Photonic crystal fibers

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Proceedings Article | 2 March 2022 Presentation

Label-free multimodal multiphoton imaging of Liver-on-a-Chip models

Aneesh Alex, Terrence Roh, BanuPriya Sridharan, Jindou Shi, Prabuddha Mukherjee, Eric Chaney, James Tunstead, Jan Majer, Kajari Bera, Darold Spillman, Marina Marjanovic, Jason Ekert, Steve Hood, Stephen Boppart

Proceedings Volume PC11972, PC1197202 (2022) https://doi.org/10.1117/12.2608861

KEYWORDS: Liver, Multiphoton microscopy, Multimodal imaging, 3D modeling, Multiphoton fluorescence microscopy, Microscopy, Optical imaging, Fluorescence lifetime imaging, Toxicology, Tissues

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Proceedings Article | 2 March 2022 Presentation

FOCALS microscopy: a label-free single-source multimodal optical system for holistic characterization of dynamic living samples

Rishyashring Iyer, Janet Sorrells, Lingxiao Yang, Eric Chaney, Haohua Tu, Marina Marjanovic, Stephen Boppart

Proceedings Volume PC11972, PC1197203 (2022) https://doi.org/10.1117/12.2609386

KEYWORDS: Microscopy, Adaptive optics, Luminescence, In vivo imaging, Sensors, Optical aberrations, In vitro testing, Harmonic generation, Coherence imaging, Tumors

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Proceedings Article | 2 March 2022 Presentation

Doppler shift induced by dynamic light scattering of biofilm morphology transition

Honggu Choi, Farzana Zaki, Guillermo Monroy, Jungeun Won, Stephen Boppart

Proceedings Volume PC11959, PC1195905 (2022) https://doi.org/10.1117/12.2609802

KEYWORDS: Doppler tomography, Dynamic light scattering, Diffusion, Biological research, Structural dynamics, Optical coherence tomography, Interfaces

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Proceedings Article | 5 March 2021 Presentation

Inactivation and sensitization of middle ear infection related bacteria and biofilm by microplasma jet array

Jungeun Won, Peter Sun, Gabrielle Choo-Kang, Shouyan Li, Wenyuan Chen, Guillermo Monroy, Eric Chaney, J. Eden, Thanh Nguyen, Stephen Boppart

Proceedings Volume 11626, 116260K (2021) https://doi.org/10.1117/12.2577424

KEYWORDS: Ear, Bacteria, Plasmas, Resistance, Plasma treatment

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Proceedings Article | 5 March 2021 Presentation

Enhancing liver on a chip Complex In Vitro Model studies using label-free optical imaging

Aneesh Alex, BanuPriya Sridharan, Edita Aksamitiene, Chi Zhang, Jindou Shi, Prabuddha Mukherjee, Mantas Zurauskas, Darold Spillman, Marina Marjanovic, Jason Ekert, Steve Hood, Stephen Boppart

Proceedings Volume 11624, 116240G (2021) https://doi.org/10.1117/12.2578531

KEYWORDS: Optical imaging, In vitro testing, Animal model studies, Multiphoton microscopy, Multiphoton fluorescence microscopy, Microscopy, 3D modeling, Tissues, Fluorescence lifetime imaging, Tumors

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Proceedings Article | 5 March 2021 Presentation

Superfast polarization-sensitive off-axis full-field optical coherence microscopy for label-free imaging of neural activity

Rishyashring Iyer, Yuan-Zhi Liu, Carlos Renteria, Mantas Žurauskas, Stephen Boppart

Proceedings Volume 11630, 1163006 (2021) https://doi.org/10.1117/12.2583679

KEYWORDS: Optical coherence microscopy, Refractive index, Birefringence, Polarization, Optogenetics, Optical networks, Optical imaging, Neural networks, Modulation, Ions

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Proceedings Article | 5 March 2021 Presentation

Label-free multimodal multiphoton imaging with deep learning for cancer detection and diagnosis

Stephen Boppart

Proceedings Volume 11634, 116340C (2021) https://doi.org/10.1117/12.2585139

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Proceedings Article | 5 March 2021 Presentation

Characterization of cellular response to extracellular vesicles using two-photon FLIM of NAD(P)H

Janet Sorrells, Elisabeth Martin, Edita Aksamitiene, Rishyashring Iyer, Lingxiao Yang, Marina Marjanovic, Stephen Boppart

Proceedings Volume 11647, 116470A (2021) https://doi.org/10.1117/12.2577668

KEYWORDS: Fluorescence lifetime imaging, Microscopy, Tumors, Tissues, Particles, Optical microscopy, Modulation, Mode conditioning cables, Breast cancer

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Proceedings Article | 5 March 2021 Presentation

Real-time phasor analysis of fast FLIM for visualizing metabolic dynamics

Janet Sorrells, Rishyashring Iyer, Lingxiao Yang, Andrew Bower, Marina Marjanovic, Stephen Boppart

Proceedings Volume 11655, 1165503 (2021) https://doi.org/10.1117/12.2576001

KEYWORDS: Fluorescence lifetime imaging, Visualization, Visual analytics, Luminescence, Imaging systems, Mode conditioning cables, Data acquisition, Biological research, Tissues, Statistical analysis

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Proceedings Article | 5 March 2021 Presentation

Differential uptake of antisense oligonucleotides in mouse hepatocytes and macrophages revealed by simultaneous 2P-fluorescence and CARS

Prabuddha Mukherjee, Edita Aksamitiene, Aneesh Alex, Derek Shi, Darold Spillman, Marina Marjanovic, Michael Fazio, Punit Seth, Kendal Frazier, Steve Hood, Stephen Boppart

Proceedings Volume 11624, 116240E (2021) https://doi.org/10.1117/12.2578037

KEYWORDS: Two photon imaging, Receptors, Luminescence, Liver, Tissues, Multimodal imaging, Molecules, Modulation, Chemistry, CARS tomography

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Proceedings Article | 5 March 2021 Presentation

In vivo optical characterization of middle ear effusions associated with otitis media

Jungeun Won, Guillermo Monroy, Ryan Porter, Michael Novak, Ronit Barkalifa, Darold Spillman, Edita Aksamitiene, Eric Chaney, Stephen Boppart

Proceedings Volume 11627, 116270A (2021) https://doi.org/10.1117/12.2577278

KEYWORDS: Ear, Optical coherence tomography, In vivo imaging, Surgery, Visualization, Testing and analysis, Scattering, Proteins, Diagnostics, Biomedical optics

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Proceedings Article | 5 March 2021 Presentation

Automated single-shot sensorless adaptive optics on a multimodal imaging platform using computational adaptive optics

Rishyashring Iyer, Janet Sorrells, Lingxiao Yang, Mantas Žurauskas, Stephen Boppart

Proceedings Volume 11652, 116520C (2021) https://doi.org/10.1117/12.2576991

KEYWORDS: Adaptive optics, Sensors, Multimodal imaging, Wavefronts, Wavefront sensors, Microscopy, Aberration correction, Optical components, Optical coherence microscopy, Optical aberrations

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Proceedings Article | 5 March 2021 Presentation

Single-cell analysis pipeline for quantification of intracellular drug distribution by CARS/2PF/FLIM

Jindou Shi, Prabuddha Mukherjee, Aneesh Alex, Edita Aksamitiene, Darold Spillman, Marina Marjanovic, Minh Doan, Steve Hood, Stephen Boppart

Proceedings Volume 11649, 1164911 (2021) https://doi.org/10.1117/12.2577041

KEYWORDS: Image analysis, Fluorescence lifetime imaging, Optical imaging, Microscopy, Luminescence, CARS tomography

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Proceedings Article | 5 March 2021 Presentation + Paper

Single-shot 4-phase shifting optical coherence microscopy

Mantas Žurauskas, Rishyashring Iyer, Stephen Boppart

Proceedings Volume 11630, 1163019 (2021) https://doi.org/10.1117/12.2583583

KEYWORDS: Optical coherence tomography, Tissues, Phase measurement, Image resolution, Coherence imaging, Speckle, Sensors, Phase shifting, Optical coherence microscopy, Imaging systems

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Proceedings Article | 5 March 2021 Presentation

Longitudinal OCT tracking of antibiotic treatment response on experimentally induced otitis media

Jungeun Won, Wenzhou Hong, Pawjai Khampang, Darold Spillman, Samuels Marshall, Ke Yan, Ryan Porter, Michael Novak, Joseph Kerschner, Stephen Boppart

Proceedings Volume 11627, 1162709 (2021) https://doi.org/10.1117/12.2577289

KEYWORDS: Optical coherence tomography, Ear, Animal model studies, Therapeutics, Luminescence, In vivo imaging, Human subjects, Diagnostics, Bacteria

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Proceedings Article | 5 March 2021 Presentation

FlimTK: a Python-based toolkit package for fluorescence lifetime imaging microscopy (FLIM) data analysis

Jindou Shi, Mantas Žurauskas, Prabuddha Mukherjee, Aneesh Alex, Darold Spillman, Marina Marjanovic, Steve Hood, Stephen Boppart

Proceedings Volume 11649, 1164907 (2021) https://doi.org/10.1117/12.2577939

KEYWORDS: Fluorescence lifetime imaging, Microscopy, Data analysis, Image analysis, Visualization, Visual analytics, Molecular biology, Luminescence, Image visualization, Graphics processing units

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Proceedings Article | 5 March 2021 Presentation

Label-Free detection of antisense oligonucleotide uptake in Murine cells using hyperspectral CARS imaging

Prabuddha Mukherjee, Aneesh Alex, Edita Aksamitiene, Derek Shi, Darold Spillman, Marina Marjanovic, Michael Fazio, Punit Seth, Kendal Frazier, Steve Hood, Stephen Boppart

Proceedings Volume 11656, 116561F (2021) https://doi.org/10.1117/12.2578061

KEYWORDS: CARS tomography, Hyperspectral imaging, Microscopy, Raman spectroscopy, Proteins, Picosecond phenomena, Molecules, Luminescence, In vivo imaging, Imaging spectroscopy

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Proceedings Article | 5 March 2021 Presentation

Phase sensitive coherence gated quantitative imaging for investigating intracellular and cellular dynamics

Mantas Žurauskas, Rishyashring Lyer, Stephen Boppart

Proceedings Volume 11653, 116530N (2021) https://doi.org/10.1117/12.2578333

KEYWORDS: Coherence imaging, Coherence (optics), Gated imaging, Phase shifts, Tissues, Phase imaging, Optical coherence microscopy, Light sources, Light emitting diodes, Interferometry

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Proceedings Article | 5 March 2021 Presentation

label-free multimodal nonlinear imaging of the treatment response in pancreatic tumor patient-derived xenografts in mice

Jaena Park, Eric Chaney, Sixian You, Amro Abdelrahman, Jennifer Leiting, Jennifer Yonkus, Peter Groves, Jonathan Harrington, Darold Spillman, Issac Lynch, Marina Marjanovic, Haohua Tu, Colleen Bushell, Heidi Nelson, Mark Truty, Stephen Boppart

Proceedings Volume 11655, 116550J (2021) https://doi.org/10.1117/12.2576912

KEYWORDS: Tumors, Multimodal imaging, Microscopy, Pancreatic cancer, In vivo imaging, Supercontinuum sources, Photonic crystal fibers, Oncology, Harmonic generation, Convolution

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SPIE Journal Paper | 26 November 2020 Open Access

Handheld optical coherence tomography for clinical assessment of dental plaque and gingiva

Jungeun Won, Pin-Chieh Huang, Darold Spillman, Eric Chaney, Ralf Adam, Malgorzata Klukowska, Ronit Barkalifa, Stephen Boppart

JBO, Vol. 25, Issue 11, 116011, (November 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.11.116011

KEYWORDS: Optical coherence tomography, Imaging systems, Teeth, Visualization, Tissues, In vivo imaging, Mirrors, Calculus, Natural surfaces, Inflammation

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SPIE Journal Paper | 11 November 2020 Open Access

Statistical evaluation of reader variability in assessing the diagnostic performance of optical coherence tomography

Sarah Erickson-Bhatt, Douglas Simpson, Stephen Boppart

JBO, Vol. 25, Issue 11, 116002, (November 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.11.116002

KEYWORDS: Optical coherence tomography, Statistical analysis, Diagnostics, Cancer, Tumors, Surgery, Tissues, Breast, Imaging systems, Image analysis

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SPIE Journal Paper | 3 November 2020 Open Access

Simultaneous two-photon activation and imaging of neural activity based on spectral–temporal modulation of supercontinuum light

Yuan-Zhi Liu, Carlos Renteria, Connor Courtney, Baher Ibrahim, Sixian You, Eric Chaney, Ronit Barkalifa, Rishyashring Iyer, Mantas Zurauskas, Haohua Tu, Daniel Llano, Catherine Christian-Hinman, Stephen Boppart

NPh, Vol. 7, Issue 04, 045007, (November 2020) https://doi.org/10.1117/12.10.1117/1.NPh.7.4.045007

KEYWORDS: Calcium, Optogenetics, Brain, Image compression, Two photon imaging, Imaging systems, Supercontinuum sources, Neuroimaging, Luminescence, Light sources

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Proceedings Article | 10 March 2020 Presentation

Tracing the formation and degradation of fatty-acid-rich mitochondria using label-free chemical imaging (Conference Presentation)

Chi Zhang, Stephen Boppart

Proceedings Volume 11252, 112521V (2020) https://doi.org/10.1117/12.2546083

KEYWORDS: Imaging spectroscopy, Microscopy, Visualization, Imaging technologies, Raman spectroscopy, Raman scattering, CARS tomography, Cancer, Mode conditioning cables

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Proceedings Article | 10 March 2020 Presentation

Rapid detection of antibiotic-resistant bacteria at the single-cell level using two-photon excitation fluorescence and coherent anti-Stokes Raman scattering microscopy (Conference Presentation)

Chi Zhang, Jungeun Won, Stephen Boppart

Proceedings Volume 11223, 112230B (2020) https://doi.org/10.1117/12.2545438

KEYWORDS: Bacteria, Luminescence, CARS tomography, Microscopy, Resistance, Mode conditioning cables, Diagnostics, Pathogens, Molecules

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Proceedings Article | 9 March 2020 Presentation

Label-free multi-modal multiphoton imaging for real-time point-of-procedure assessment of core-needle and fine-needle biopsy specimens (Conference Presentation)

Lingxiao Yang, Yi Sun, Darold Spillman, Sixian You, Stephen Boppart

Proceedings Volume 11234, 112340X (2020) https://doi.org/10.1117/12.2543216

KEYWORDS: Biopsy, Real time imaging, Multimodal imaging, Tissues, Tumors, Imaging systems, Fine needle aspiration, Error analysis, Luminescence, Harmonic generation

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Proceedings Article | 9 March 2020 Presentation

Understanding opioid-induced metabolic changes in brain and neurons using label-free multimodal nonlinear optical imaging (Conference Presentation)

Chi Zhang, Jaena Park, Carlos Renteria, Eric Chaney, Stephen Boppart

Proceedings Volume 11226, 112260O (2020) https://doi.org/10.1117/12.2546179

KEYWORDS: Brain, Neurons, Neuroimaging, Multimodal imaging, Optical imaging, Mode conditioning cables, Molecules, Magnetic resonance imaging, Positron emission tomography, Electroencephalography

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Proceedings Article | 9 March 2020 Presentation

Dynamic signatures of lipid droplets reveal cellular metabolic changes associated with stimuli and drug treatments (Conference Presentation)

Chi Zhang, Stephen Boppart

Proceedings Volume 11243, 112430V (2020) https://doi.org/10.1117/12.2545387

KEYWORDS: CARS tomography, Microscopy, Statistical analysis, Testing and analysis, Molecules, Imaging technologies, Luminescence, Cancer, Oncology, Cell death

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Proceedings Article | 7 March 2019 Presentation

Compact low-cost briefcase OCT system with automated classification for point-of-care diagnosis of otitis media (Conference Presentation)

Roshan Dsouza, Jungeun Won, Guillermo Monroy, Darold Spillman, Stephen Boppart

Proceedings Volume 10869, 1086908 (2019) https://doi.org/10.1117/12.2508010

KEYWORDS: Optical coherence tomography, Point-of-care devices, Classification systems, Diagnostics, Ear, Computing systems, Video

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Proceedings Article | 7 March 2019 Presentation

Detecting the efficacy of endotracheal tube suctioning in intubated ICU patients using in vivo catheter-based OCT (Conference Presentation)

Roshan Dsouza, Darold Spillman, Ronit Barkalifa, Guillermo Monroy, Eric Chaney, Karen White, Stephen Boppart

Proceedings Volume 10853, 108530C (2019) https://doi.org/10.1117/12.2508022

KEYWORDS: Optical coherence tomography, In vivo imaging, Bacteria, Image analysis, Pathogens, Resistance, 3D image processing, Stereoscopy, Human subjects, Luminescence

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Proceedings Article | 4 March 2019 Presentation

Drug toxicity assessment using label-free multimodal nonlinear optical imaging (Conference Presentation)

Aneesh Alex, Jang Hyuk Lee, Jose Rico-Jimenez, Eric Chaney, Sunish Mohanan, Stephen Boppart, Steve Hood

Proceedings Volume 10859, 108590I (2019) https://doi.org/10.1117/12.2510032

KEYWORDS: Toxicity, Multimodal imaging, Optical imaging, Multiphoton microscopy, Multiphoton fluorescence microscopy, Microscopy, Fluorescence lifetime imaging, Toxicology, Drug development, Drug discovery

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Proceedings Article | 4 March 2019 Presentation

Label-free multimodal multiphoton microscopy for monitoring of cell and tissue preservation and degradation in ex vivo whole organs (Conference Presentation)

Jang Hyuk Lee, Aneesh Alex, Jose Rico-Jimenez, Eric Chaney, Steve Hood, Stephen Boppart

Proceedings Volume 10881, 108810D (2019) https://doi.org/10.1117/12.2507482

KEYWORDS: Tissues, Multiphoton microscopy, Fluorescence lifetime imaging, Optical properties, Ultrafast imaging, Nonlinear optics, Light-matter interactions, Signal generators, Cell mechanics, Image processing

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SPIE Journal Paper | 24 September 2018 Open Access

Economical and compact briefcase spectral-domain optical coherence tomography system for primary care and point-of-care applications

Roshan Dsouza, Jungeun Won, Guillermo Monroy, Darold Spillman, Stephen Boppart

JBO, Vol. 23, Issue 09, 096003, (September 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.9.096003

KEYWORDS: Optical coherence tomography, Imaging systems, Spectroscopy, In vivo imaging, Point-of-care devices, Skin, Mirrors, Sensors, CCD cameras, Image registration

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Proceedings Article | 15 March 2018 Presentation

Highly integrated label-free multiphoton nonlinear optical microspectroscopy imaging system for biomolecular imaging (Conference Presentation)

Jang Hyuk Lee, Jose Rico-Jimenez, Aneesh Alex, Eric Chaney, Ronit Barkalifa, Haohua Tu, Marina Marjanovic, Zane Arp, Stephen Boppart

Proceedings Volume 10505, 105050V (2018) https://doi.org/10.1117/12.2287194

KEYWORDS: Luminescence, Imaging systems, Imaging spectroscopy, Multiphoton fluorescence microscopy, Multiphoton microscopy, Microscopy, Spectroscopy, Optical coherence tomography, Fluorescence lifetime imaging, Harmonic generation

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Proceedings Article | 14 March 2018 Presentation

Intraoperative determination of tumor aggressiveness by real-time label-free nonlinear imaging and characterization of tumor-associated extracellular vesicles (Conference Presentation)

Yi Sun, Sixian You, Haohua Tu, Darold Spillman, Marina Marjanovic, Eric Chaney, George Liu, Anna Higham, Kimberly Cradock, Stephen Boppart

Proceedings Volume 10478, 1047805 (2018) https://doi.org/10.1117/12.2288818

KEYWORDS: Tumors, Breast cancer, Breast, Tissues, Imaging systems, Harmonic generation, Auto-fluorescence imaging, Real time imaging, Collagen, Visualization

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Proceedings Article | 14 March 2018 Presentation

Detecting testicular toxicity using label-free multimodal nonlinear optical imaging (Conference Presentation)

Aneesh Alex, Jang Hyuk Lee, Jose Rico-Jimenez, Sunish Mohanan, Stephen Boppart, Zane Arp

Proceedings Volume 10486, 104860B (2018) https://doi.org/10.1117/12.2290646

KEYWORDS: Multiphoton microscopy, Multiphoton fluorescence microscopy, Microscopy, Toxicity, Optical imaging, Nonlinear optics, Safety, Fluorescence lifetime imaging, Tissue optics, Multimodal imaging

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Proceedings Article | 14 March 2018 Presentation

Noninvasive monitoring of pharmacodynamics in the skin wound healing process using multimodal microscopy (Conference Presentation)

Jose Rico-Jimenez, Jang Hyuk Lee, Aneesh Alex, Eric Chaney, Ronit Barkalifa, Eric Olson, David Adams, Marina Marjanovic, Zane Arp, Stephen Boppart

Proceedings Volume 10475, 104750C (2018) https://doi.org/10.1117/12.2288621

KEYWORDS: Wound healing, Microscopy, Fluorescence lifetime imaging, Collagen, Skin, Optical coherence tomography, Angiography, Harmonic generation, Raman scattering, Multimodal imaging

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Proceedings Article | 14 March 2018 Presentation

Computational algorithm for assessing inter-neuronal connectivity to optimize optogenetic stimulation and neural circuit activity (Conference Presentation)

Carlos Renteria, Shreya Santhanam, Yuan-Zhi Liu, Denise Medina, Parijat Sengupta, Stephen Boppart

Proceedings Volume 10482, 1048210 (2018) https://doi.org/10.1117/12.2291233

KEYWORDS: Brain, Imaging systems, Optogenetics, Genetic algorithms, Algorithm development, Neuroscience, Machine learning, Signal processing, Neuroimaging, Calcium

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Proceedings Article | 14 March 2018 Presentation

Reconstruction and depixelation of multicore fiber bundle images by fiber bundle rotation (Conference Presentation)

Carlos Renteria, Javier Suarez, Parijat Sengupta, Stephen Boppart

Proceedings Volume 10481, 104810Q (2018) https://doi.org/10.1117/12.2291297

KEYWORDS: Image restoration, Optogenetics, Neuroscience, Brain, Fiber optics, Image processing, Neurons, Neurophotonics, Image quality, Reconstruction algorithms

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SPIE Journal Paper | 29 December 2017 Open Access

Label-free optical imaging technologies for rapid translation and use during intraoperative surgical and tumor margin assessment

Stephen A. Boppart, J. Quincy Brown, Camile S. Farah, Esther Kho, Laura Marcu, Christobel M. Saunders, Henricus J. C. M. Sterenborg

JBO, Vol. 23, Issue 02, 021104, (December 2017) https://doi.org/10.1117/12.10.1117/1.JBO.23.2.021104

KEYWORDS: Tumors, Tissues, Optical imaging, Surgery, Tissue optics, In vivo imaging, Biomedical optics, Pathology, Natural surfaces, Cancer

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SPIE Journal Paper | 23 December 2017 Open Access

Noninvasive in vivo optical coherence tomography tracking of chronic otitis media in pediatric subjects after surgical intervention

Guillermo Monroy, Paritosh Pande, Ryan Nolan, Ryan Shelton, Ryan Porter, Michael Novak, Darold Spillman, Eric Chaney, Daniel McCormick, Stephen Boppart

JBO, Vol. 22, Issue 12, 121614, (December 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.12.121614

KEYWORDS: Optical coherence tomography, Surgery, Ear, Bragg cells, In vivo imaging, Visualization, Optical tracking, Imaging systems, Diagnostics, Image analysis

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SPIE Journal Paper | 23 December 2017 Open Access

Biophotonics: the big picture

Laura Marcu, Stephen A. Boppart, Mark Hutchinson, Jürgen Popp, Brian Wilson

JBO, Vol. 23, Issue 02, 021103, (December 2017) https://doi.org/10.1117/12.10.1117/1.JBO.23.2.021103

KEYWORDS: Biomedical optics, Medicine, Imaging systems, Photonics, Image processing, Biology, Optical imaging, Visualization, Interference (communication), Signal detection

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SPIE Journal Paper | 22 December 2017 Open Access

Review of optical coherence tomography in oncology

Jianfeng Wang, Yang Xu, Stephen Boppart

JBO, Vol. 22, Issue 12, 121711, (December 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.12.121711

KEYWORDS: Optical coherence tomography, Tumors, Cancer, Oncology, Tissues, Tissue optics, In vivo imaging, Breast, Bladder, Brain

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SPIE Journal Paper | 19 December 2017 Open Access

Clinical translation of handheld optical coherence tomography: practical considerations and recent advancements

Guillermo Monroy, Jungeun Won, Darold Spillman, Roshan Dsouza, Stephen Boppart

JBO, Vol. 22, Issue 12, 121715, (December 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.12.121715

KEYWORDS: Optical coherence tomography, Imaging systems, Tissues, Computer aided design, Ear, In vivo imaging, Surgery, Retina, Visualization, Tissue optics

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SPIE Journal Paper | 25 July 2017 Open Access

Intracellular imaging of docosanol in living cells by coherent anti-Stokes Raman scattering microscopy

Sixian You, Yuan Liu, Zane Arp, Youbo Zhao, Eric Chaney, Marina Marjanovic, Stephen Boppart

JBO, Vol. 22, Issue 07, 070502, (July 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.7.070502

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Proceedings Article | 21 April 2017 Presentation

Photonic crystal fiber-generated coherent supercontinuum for fast stain-free histopathology and intraoperative multiphoton imaging (Conference Presentation)

Haohua Tu, Sixian You, Yi Sun, Darold Spillman, Partha Ray, George Liu, Stephen Boppart

Proceedings Volume 10094, 1009402 (2017) https://doi.org/10.1117/12.2252096

KEYWORDS: Breast cancer, Pollution control, Fiber lasers, Supercontinuum generation, Cancer, Surgery, Photonic crystals, Sapphire lasers, Biophotonic applications, Laser resonators

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Proceedings Article | 19 April 2017 Presentation

Spectral-temporal modulation of supercontinuum generation for two-photon optogenetics (Conference Presentation)

Yuan-Zhi Liu, Haohua Tu, Javier Suarez, Parijat Sengupta, Stephen Boppart

Proceedings Volume 10052, 100520M (2017) https://doi.org/10.1117/12.2251501

KEYWORDS: Neurons, Optogenetics, Supercontinuum generation, Two photon imaging, Calcium, Modulation, Tunable lasers, Femtosecond phenomena, Genetics, Neuroscience

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Proceedings Article | 19 April 2017 Presentation

Spatial control of in vivo optogenetic light stimulation and recording via an imaging fiber bundle (Conference Presentation)

Javier Suárez, Parijat Sengupta, Jonathan Guo-Han Mun, Justin Rhodes, Stephen Boppart

Proceedings Volume 10052, 1005203 (2017) https://doi.org/10.1117/12.2252582

KEYWORDS: In vivo imaging, Neurons, Optogenetics, Multimode fibers, Brain, Optical imaging, Neuroimaging, Optical recording, Objectives, Continuous wave operation

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Proceedings Article | 19 April 2017 Presentation

Automated computational aberration correction method for OCT and OCM (Conference Presentation)

Yuan-Zhi Liu, Paritosh Pande, Fredrick South, Stephen Boppart

Proceedings Volume 10053, 100530V (2017) https://doi.org/10.1117/12.2251514

KEYWORDS: Evolutionary algorithms, Image resolution, Optical coherence tomography, Aberration correction, Adaptive optics, Imaging systems, Image filtering, Tissue optics, Image processing, Zernike polynomials

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Proceedings Article | 19 April 2017 Presentation

Imaging bio-distribution of a topically applied dermatological cream on minipig skin using fluorescence lifetime imaging microscopy (Conference Presentation)

Aneesh Alex, Eric Chaney, Jennifer Criley, Darold Spillman, Phaedra Hutchison, Joanne Li, Marina Marjanovic, Steve Frey, Steven Cook, Stephen Boppart, Zane Arp

Proceedings Volume 10046, 100460E (2017) https://doi.org/10.1117/12.2253112

KEYWORDS: Optical tracking, Skin, Fluorescence lifetime imaging, Multiphoton fluorescence microscopy, Multiphoton microscopy, Microscopy, Optical imaging, Biopsy, Visualization, In vivo imaging

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Proceedings Article | 19 April 2017 Presentation

Intra-operative label-free multimodal multiphoton imaging of breast cancer margins and microenvironment (Conference Presentation)

Yi Sun, Sixian You, Haohua Tu, Darold Spillman, Marina Marjanovic, Eric Chaney, George Liu, Partha Ray, Anna Higham, Stephen Boppart

Proceedings Volume 10043, 1004307 (2017) https://doi.org/10.1117/12.2251057

KEYWORDS: Tumors, Imaging systems, Breast cancer, Multimodal imaging, Microscopes, Tissues, Breast, Mammography, Laser tissue interaction, Laser sources

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SPIE Journal Paper | 1 March 2017 Open Access

Quantitative characterization of mechanically indented in vivo human skin in adults and infants using optical coherence tomography

Pin-Chieh Huang, Paritosh Pande, Ryan L. Shelton, Frank Joa, Dave Moore, Elisa Gillman, Kimberly Kidd, Ryan Nolan, Mauricio Odio, Andrew Carr, Stephen Boppart

JBO, Vol. 22, Issue 03, 034001, (March 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.3.034001

KEYWORDS: Skin, Optical coherence tomography, Tissues, Tissue optics, In vivo imaging, Natural surfaces, Human subjects, Collagen, Image resolution, Pathology

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SPIE Journal Paper | 31 October 2016 Open Access

Rapid diagnosis and differentiation of microbial pathogens in otitis media with a combined Raman spectroscopy and low-coherence interferometry probe: toward in vivo implementation

Youbo Zhao, Guillermo Monroy, Sixian You, Ryan Shelton, Ryan Nolan, Haohua Tu, Eric Chaney, Stephen Boppart

JBO, Vol. 21, Issue 10, 107005, (October 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.10.107005

KEYWORDS: Raman spectroscopy, Ear, Pathogens, Remote sensing, In vivo imaging, Surface plasmons, Tissues, Microorganisms, Spectroscopy, Bacteria

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SPIE Journal Paper | 2 September 2016 Open Access

Ratiometric analysis of in vivo retinal layer thicknesses in multiple sclerosis

Basanta Bhaduri, Ryan Nolan, Ryan Shelton, Lara Pilutti, Robert W. Motl, Stephen Boppart

JBO, Vol. 21, Issue 09, 095001, (September 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.9.095001

KEYWORDS: Optical coherence tomography, Image segmentation, In vivo imaging, Biological research, Statistical analysis, Visualization, Nerve, Retina, Magnetic resonance imaging, Pathology

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SPIE Journal Paper | 16 August 2016 Open Access

In vivo evaluation of adipose- and muscle-derived stem cells as a treatment for nonhealing diabetic wounds using multimodal microscopy

Joanne Li, Yair Pincu, Marina Marjanovic, Andrew Bower, Eric Chaney, Tor Jensen, Marni Boppart, Stephen Boppart

JBO, Vol. 21, Issue 08, 086006, (August 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.8.086006

KEYWORDS: Stem cells, Skin, Collagen, Wound healing, Second-harmonic generation, Photography, In vivo imaging, Microscopy, Imaging systems, Visualization

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Proceedings Article | 27 April 2016 Presentation

Magnetic hyperthermia dosimetry by biomechanical properties revealed in magnetomotive optical coherence elastography (MM-OCE) (Conference Presentation)

Pin-Chieh Huang, Marina Marjanovic, Darold Spillman, Boris Odintsov, Stephen Boppart

Proceedings Volume 9722, 972211 (2016) https://doi.org/10.1117/12.2213198

KEYWORDS: Tissues, Magnetism, Elastography, Tissue optics, Coherence (optics), Temperature metrology, Nanoparticles, Solids, Tumors, Injuries

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Proceedings Article | 27 April 2016 Presentation

Magnetomotive optical coherence elastography (MM-OCE) for thermal therapy dosimetry (Conference Presentation)

Pin-Chieh Huang, Marina Marjanovic, Darold Spillman, Boris Odintsov, Stephen Boppart

Proceedings Volume 9710, 97100R (2016) https://doi.org/10.1117/12.2213145

KEYWORDS: Tissues, Magnetism, Tissue optics, Elastography, Coherence (optics), Thermography, Tumors, Temperature metrology, Nanoparticles, Injuries

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Proceedings Article | 27 April 2016 Presentation

Differentiation of bacterial versus viral otitis media using a combined Raman scattering spectroscopy and low coherence interferometry probe (Conference Presentation)

Youbo Zhao, Ryan Shelton, Haohua Tu, Ryan Nolan, Guillermo Monroy, Eric Chaney, Stephen Boppart

Proceedings Volume 9689, 96892E (2016) https://doi.org/10.1117/12.2211824

KEYWORDS: Raman spectroscopy, Raman scattering, Interferometry, Spectroscopy, Molecular spectroscopy, Diagnostics, Resistance, Spectroscopes, Viruses, Bacteria

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Proceedings Article | 27 April 2016 Presentation

Comparison of advanced optical imaging techniques with current otolaryngology diagnostics for improved middle ear assessment (Conference Presentation)

Ryan Nolan, Ryan Shelton, Guillermo Monroy, Darold Spillman, Michael Novak, Stephen Boppart

Proceedings Volume 9689, 96892J (2016) https://doi.org/10.1117/12.2213158

KEYWORDS: Ear, Diagnostics, Optical imaging, Optical coherence tomography, Doppler tomography, Vibrometry, Acoustics, Reflectometry, Standards development, Tissues

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Proceedings Article | 27 April 2016 Presentation

A novel mosaicking algorithm for in vivo full-field thickness mapping of the human tympanic membrane using low coherence interferometry (Conference Presentation)

Paritosh Pande, Ryan Shelton, Guillermo Monroy, Ryan Nolan, Stephen Boppart

Proceedings Volume 9689, 96892C (2016) https://doi.org/10.1117/12.2213636

KEYWORDS: In vivo imaging, Interferometry, Imaging systems, Image registration, Ear, Pathology, Coherence (optics), Video, Biomedical optics, Retinal scanning

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Proceedings Article | 27 April 2016 Presentation

Investigation of an angiogenesis-promoting topical treatment for diabetic wounds using multimodal microscopy (Conference Presentation)

Joanne Li, Andrew Bower, Zane Arp, Eric Olson, Claire Holland, Eric Chaney, Marina Marjanovic, Stephen Boppart

Proceedings Volume 9689, 96890I (2016) https://doi.org/10.1117/12.2211647

KEYWORDS: Wound healing, Microscopy, Skin, Hypoxia, Fluorescence lifetime imaging, Oxygen, Tissues, In vivo imaging, Optical coherence tomography, Control systems

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Proceedings Article | 26 April 2016 Presentation

Development of a low-cost hand-held system for optical coherence tomography imaging (Conference Presentation)

Paritosh Pande, Ryan Shelton, Guillermo Monroy, Ryan Nolan, Stephen Boppart

Proceedings Volume 9697, 96971D (2016) https://doi.org/10.1117/12.2213660

KEYWORDS: Imaging systems, Optical coherence tomography, Coherence imaging, Optical imaging, Interferometers, Signal to noise ratio, Coherence (optics), Light, Beam splitters, Detector arrays

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Proceedings Article | 26 April 2016 Presentation

Spatially controlled optogenetic light stimulation and recording platform via imaging fiber bundles (Conference Presentation)

Javier Suárez, Parijat Sengupta, Jonathan Mun, Rajashekar Iyer, Justin Rhodes, Martha Gillette, Stephen Boppart

Proceedings Volume 9690, 969029 (2016) https://doi.org/10.1117/12.2213320

KEYWORDS: Optogenetics, In vivo imaging, Multimode fibers, Neurons, Optical imaging, Brain, Optical recording, Objectives, Continuous wave operation, Semiconductor lasers

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Proceedings Article | 4 March 2016 Paper

Computational adaptive optics of the human retina

Fredrick South, Yuan-Zhi Liu, P. Scott Carney, Stephen Boppart

Proceedings Volume 9693, 96931F (2016) https://doi.org/10.1117/12.2213523

KEYWORDS: Optical coherence tomography, Adaptive optics, Retina, Aberration correction, Wavefronts, Interferometry, Retinal scanning, Data acquisition, Wavefront sensors, Spatial frequencies

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Proceedings Article | 12 March 2015 Paper

A computational approach to high-resolution imaging of the living human retina without hardware adaptive optics

Nathan Shemonski, Steven Adie, Yuan-Zhi Liu, Fredrick South, P. Carney, Stephen Boppart

Proceedings Volume 9307, 930710 (2015) https://doi.org/10.1117/12.2078308

KEYWORDS: Optical coherence tomography, Retina, Aberration correction, Imaging systems, Eye, Adaptive optics, In vivo imaging, Motion measurement, Cones, Computer simulations

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Proceedings Article | 10 March 2015 Paper

Computational adaptive optics for broadband optical interferometric tomography of biological tissue

Stephen Boppart

Proceedings Volume 9335, 933505 (2015) https://doi.org/10.1117/12.2078050

KEYWORDS: Optical coherence tomography, Adaptive optics, Tissues, Tissue optics, Interferometry, Tomography, Imaging systems, Aberration correction, Scattering, Optical tomography

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SPIE Journal Paper | 3 December 2014 Open Access

Volumetric full-range magnetomotive optical coherence tomography

Adeel Ahmad, Jongsik Kim, Nathan Shemonski, Marina Marjanovic, Stephen Boppart

JBO, Vol. 19, Issue 12, 126001, (December 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.12.126001

KEYWORDS: Optical coherence tomography, Modulation, Magnetism, Tissues, Signal processing, Particles, Data acquisition, 3D acquisition, 3D image processing, Line scan image sensors

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Proceedings Article | 4 March 2014 Paper

Real-time computed optical interferometric tomography

Nathan Shemonski, Yuan-Zhi Liu, Adeel Ahmad, Steven Adie, P. Scott Carney, Stephen Boppart

Proceedings Volume 8934, 89341W (2014) https://doi.org/10.1117/12.2041938

KEYWORDS: Optical coherence tomography, Tissue optics, Cameras, In vivo imaging, Tomography, Interferometry, Computed tomography, Data acquisition, Optical aberrations, Optical tomography

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Proceedings Article | 28 February 2014 Paper

Implementation and evaluation of Google Glass for visualizing real-time image and patient data in the primary care office

Guillermo Monroy, Nathan Shemonski, Ryan Shelton, Ryan Nolan, Stephen Boppart

Proceedings Volume 8935, 893514 (2014) https://doi.org/10.1117/12.2040221

KEYWORDS: Glasses, Medicine, Imaging systems, Diagnostics, Optical coherence tomography, Image visualization, Heads up displays, Video, Visualization, Tissues

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Proceedings Article | 27 February 2014 Paper

In vivo intra-operative breast tumor margin detection using a portable OCT system with a handheld surgical imaging probe

Sarah Erickson-Bhatt, Ryan Nolan, Nathan Shemonski, Steven Adie, Jeffrey Putney, Donald Darga, Daniel McCormick, Andrew Cittadine, Marina Marjanovic, Eric Chaney, Guillermo Monroy, Fredrick South, P. Scott Carney, Kimberly Cradock, Z. George Liu, Partha Ray, Stephen Boppart

Proceedings Volume 8935, 89351C (2014) https://doi.org/10.1117/12.2040315

KEYWORDS: Tumors, Optical coherence tomography, Surgery, In vivo imaging, Imaging systems, Tissues, Breast, Breast cancer, Mammography, Tissue optics

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SPIE Journal Paper | 19 December 2013 Open Access

Special Section Guest Editorial: Optical Elastography and Measurement of Tissue Biomechanics

Ruikang Wang, David Sampson, Stephen Boppart, Brendan Kennedy

JBO, Vol. 18, Issue 12, 121501, (December 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.12.121501

KEYWORDS: Tissue optics, Elastography, Tissues, Optical testing, Tumors, Ultrasonography, Optical coherence tomography, Magnetic resonance imaging, Spatial resolution, Cancer

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SPIE Journal Paper | 21 October 2013 Open Access

Magnetomotive optical coherence elastography for microrheology of biological tissues

Vasilica Crecea, Adeel Ahmad, Stephen Boppart

JBO, Vol. 18, Issue 12, 121504, (October 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.12.121504

KEYWORDS: Tissues, Magnetism, Elastography, Lung, Tissue optics, Coherence (optics), Biomedical optics, Data acquisition, Optical coherence tomography, Nanoparticles

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Proceedings Article | 20 May 2013 Paper

Optical coherence tomography for the diagnosis of human otitis media

Nam Hyun Cho, Unsang Jung, Jeong Hun Jang, Woonggyu Jung, Jeehyun Kim, Sang Heun Lee, Stephen Boppart

Proceedings Volume 8879, 88790N (2013) https://doi.org/10.1117/12.2017723

KEYWORDS: Optical coherence tomography, Ear, In vivo imaging, Diagnostics, Information visualization, Thulium, Visualization, Adhesives, Image resolution, Imaging spectroscopy

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Proceedings Article | 20 March 2013 Paper

Interferometric synthetic aperture microscopy implementation on a floating point multi-core digital signal processer

Adeel Ahmad, Murtaza Ali, Fredrick South, Guillermo Monroy, Steven Adie, Nathan Shemonski, P. Scott Carney, Stephen Boppart

Proceedings Volume 8571, 857134 (2013) https://doi.org/10.1117/12.2006876

KEYWORDS: Digital signal processing, Optical coherence tomography, Signal processing, Data processing, Image processing, Interferometry, Synthetic aperture microscopy, Fourier transforms, Infinite impulse response filters, Graphics processing units

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Proceedings Article | 11 December 2012 Paper

Coherent fiber supercontinuum laser for nonlinear biomedical imaging

Haohua Tu, Yuan Liu, Xiaomin Liu, Jesper Lægsgaard, Dmitry Turchinovich, Stephen Boppart

Proceedings Volume 8553, 85530A (2012) https://doi.org/10.1117/12.999522

KEYWORDS: Fiber lasers, Optical imaging, Photonic crystal fibers, Biomedical optics, Femtosecond phenomena, Ytterbium, Optical coherence tomography, Nonlinear optics, Raman spectroscopy, Sapphire lasers

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Proceedings Article | 10 June 2011 Paper

Molecular histopathology by nonlinear interferometric vibrational imaging

Stephen Boppart

Proceedings Volume 8087, 808704 (2011) https://doi.org/10.1117/12.889782

KEYWORDS: Tissues, Raman spectroscopy, Interferometry, Photons, Molecules, Tumors, Raman scattering, Signal processing, Tissue optics, Biomedical optics

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Proceedings Article | 28 February 2011 Paper

Long-term time-lapse multimodal microscopy for tracking cell dynamics in live tissue

Benedikt Graf, Maria Valero, Eric Chaney, Marina Marjanovic, Marni Boppart, Stephen Boppart

Proceedings Volume 7902, 790206 (2011) https://doi.org/10.1117/12.874183

KEYWORDS: Skin, Tissues, Microscopy, Green fluorescent protein, Visualization, Bone, Multiphoton microscopy, Time lapse microscopy, Image registration, Ions

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Proceedings Article | 16 February 2011 Open Access

Magnetomotive optical coherence microscopy for cell dynamics and biomechanics

Xing Liang, Benedikt Graf, Renu John, Vasilica Crecea, Freddy Nguyen, Huafeng Ding, Hyon-min Song, Gabriel Popescu, Alexander Wei, Stephen Boppart

Proceedings Volume 7889, 788926 (2011) https://doi.org/10.1117/12.875139

KEYWORDS: Magnetism, Modulation, Microscopy, Transducers, Nanoparticles, Light scattering, Diffraction, Luminescence, Fourier transforms, Coherence imaging

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Proceedings Article | 16 February 2011 Paper

Low power real time signal processing engine for optical coherence tomography systems using multi-core digital signal processor

Murtaza Ali, Renuka Parlapalli, Renu John, Stephen Boppart

Proceedings Volume 7889, 78892J (2011) https://doi.org/10.1117/12.875523

KEYWORDS: Digital signal processing, Signal processing, Optical coherence tomography, Imaging systems, Image restoration, Optical signal processing, Coherence imaging, Image processing, Coherence (optics), Surgery

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Proceedings Article | 16 February 2011 Paper

The impact of aberrations on object reconstruction with interferometric synthetic aperture microscopy

Steven Adie, Benedikt Graf, Adeel Ahmad, Budiman Darbarsyah, Stephen Boppart, P. Scott Carney

Proceedings Volume 7889, 78891O (2011) https://doi.org/10.1117/12.875592

KEYWORDS: Point spread functions, Monochromatic aberrations, Optical coherence tomography, Objectives, Interferometry, Synthetic aperture microscopy, Fourier transforms, Signal detection, Gaussian beams, Imaging systems

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Proceedings Article | 12 February 2011 Paper

Magnetomotive molecular probes for targeted contrast enhancement and therapy

Stephen Boppart

Proceedings Volume 7910, 791004 (2011) https://doi.org/10.1117/12.873862

KEYWORDS: Magnetism, Tissues, Optical coherence tomography, In vivo imaging, Modulation, Scattering, Biomedical optics, Tumors, Magnetic resonance imaging, Cancer

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SPIE Journal Paper | 1 November 2010 Open Access

Numerical analysis of gradient index lens-based optical coherence tomography imaging probes

Woonggyu Jung, Wladimir Benalcazar, Adeel Ahmad, Utkarsh Sharma, Haohua Tu, Stephen Boppart

JBO, Vol. 15, Issue 06, 066027, (November 2010) https://doi.org/10.1117/12.10.1117/1.3523374

KEYWORDS: GRIN lenses, Refractive index, Optical coherence tomography, Prisms, Numerical analysis, Coherence imaging, Cements, Single mode fibers, Optical fibers, Endoscopy

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Proceedings Article | 26 February 2010 Paper

Versatile photonic crystal fiber-enabled source for multi-modality biophotonic imaging beyond conventional multiphoton microscopy

Haohua Tu, Stephen Boppart

Proceedings Volume 7569, 75692D (2010) https://doi.org/10.1117/12.841298

KEYWORDS: Solitons, Multiphoton microscopy, Biomedical optics, Microscopy, Fluorescence lifetime imaging, Fiber lasers, Confocal microscopy, Supercontinuum generation, Picosecond phenomena, Transient nonlinear optics

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SPIE Journal Paper | 1 May 2009 Open Access

Dual-spectrum laser source based on fiber continuum generation for integrated optical coherence and multiphoton microscopy

Benedikt Graf, Zhi Jiang, Haohua Tu, Stephen Boppart

JBO, Vol. 14, Issue 03, 034019, (May 2009) https://doi.org/10.1117/12.10.1117/1.3147422

KEYWORDS: Photonic crystal fibers, Sapphire lasers, In vivo imaging, Laser sources, Coherence (optics), Multiphoton microscopy, Skin, Fluorescent markers, Tissues, Beam splitters

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Proceedings Article | 20 February 2009 Paper

Validation of nonlinear interferometric vibrational imaging as a molecular OCT technique by the use of Raman microscopy

Wladimir Benalcazar, Zhi Jiang, Daniel Marks, Joseph Geddes, Stephen Boppart

Proceedings Volume 7168, 71680T (2009) https://doi.org/10.1117/12.809384

KEYWORDS: Raman spectroscopy, Interferometry, Microscopy, Tissues, Optical coherence tomography, Signal processing, Raman scattering, Photons, Silicon, Silicates

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Proceedings Article | 19 February 2009 Paper

Chirped four-wave mixing in the largely normal dispersion regime from femtosecond pulse-pumped photonic crystal fiber

Haohua Tu, Zhi Jiang, Daniel Marks, Stephen Boppart

Proceedings Volume 7195, 71952O (2009) https://doi.org/10.1117/12.808879

KEYWORDS: Dispersion, Femtosecond phenomena, Four wave mixing, Photonic crystal fibers, Spectroscopy, Near field, Ultrafast laser spectroscopy, Visible radiation, Spectrum analysis, Refractive index

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Proceedings Article | 13 February 2009 Paper

Optical pulse shaping for selective excitation of coherent molecular vibrations by stimulated Raman scattering

Joseph Geddes, Daniel Marks, Stephen Boppart

Proceedings Volume 7183, 718311 (2009) https://doi.org/10.1117/12.809539

KEYWORDS: Raman spectroscopy, Signal detection, Molecules, Optical design, Interferometry, Chemical species, Bioalcohols, Raman scattering, CARS tomography, Signal processing

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SPIE Journal Paper | 1 July 2008 Open Access

High-speed processing architecture for spectral-domain optical coherence microscopy

Robin Chelliyil, Tyler Ralston, Daniel Marks, Stephen Boppart

JBO, Vol. 13, Issue 04, 044013, (July 2008) https://doi.org/10.1117/12.10.1117/1.2960018

KEYWORDS: Computer architecture, Optical coherence microscopy, Optical coherence tomography, Image processing, Fourier transforms, Spectroscopy, Confocal microscopy, Biomedical optics, Objectives, Microscopes

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Proceedings Article | 17 April 2008 Open Access

Coherent optical imaging and guided interventions in breast cancer: translating technology into clinical applications

Stephen Boppart, Freddy Nguyen, Adam Zysk, Eric Chaney, Jan Kotynek, Uretz Oliphant, Frank Bellafiore, Kendrith Rowland, Patricia Johnson

Proceedings Volume 6991, 699102 (2008) https://doi.org/10.1117/12.780168

KEYWORDS: Optical coherence tomography, Tumors, Tissues, Lymphatic system, Breast cancer, Tissue optics, Cancer, Surgery, Scattering, Breast

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Proceedings Article | 22 February 2008 Paper

Magnetic protein microspheres as dynamic contrast agents for magnetomotive optical coherence tomography

Freddy Nguyen, Elizabeth Dibbern, Eric Chaney, Amy Oldenburg, Kenneth Suslick, Stephen Boppart

Proceedings Volume 6867, 68670F (2008) https://doi.org/10.1117/12.762428

KEYWORDS: Optical coherence tomography, Proteins, Magnetism, Tumors, Receptors, Nanoparticles, Oxides, Cancer, Iron, Particles

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Proceedings Article | 22 February 2008 Paper

Interferometric synthetic aperture microscopy: tissue structure inferred by computed imaging techniques

Daniel Marks, Tyler Ralston, Brynmor Davis, P. Scott Carney, Stephen Boppart

Proceedings Volume 6864, 686407 (2008) https://doi.org/10.1117/12.763390

KEYWORDS: Optical coherence tomography, Tissues, Synthetic aperture radar, Interferometry, Image processing, Signal processing, Synthetic aperture microscopy, Spatial frequencies, Tissue optics, Light scattering

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Proceedings Article | 22 February 2008 Paper

Plasmon-resonant gold nanorods provide spectroscopic OCT contrast in excised human breast tumors

Amy Oldenburg, Matthew Hansen, Alexander Wei, Stephen Boppart

Proceedings Volume 6867, 68670E (2008) https://doi.org/10.1117/12.761886

KEYWORDS: Optical coherence tomography, Tissues, Tissue optics, Spectroscopy, Tumors, Breast, Gold, Imaging spectroscopy, RGB color model, Nanorods

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Proceedings Article | 18 February 2008 Paper

Spectral-domain magnetomotive OCT imaging of magnetic nanoparticle biodistribution

Amy Oldenburg, Vasilica Crecea, Stephanie Rinne, Robabeh Rezaeipoor, Eric Chaney, Stephen Boppart

Proceedings Volume 6847, 684719 (2008) https://doi.org/10.1117/12.761931

KEYWORDS: Nanoparticles, Magnetism, Optical coherence tomography, Modulation, Magnetic resonance imaging, Signal to noise ratio, Tissues, Iron, Spleen, Tissue optics

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Proceedings Article | 15 February 2008 Paper

Nonlinear interferometric vibrational imaging of biological tissue

Zhi Jiang, Daniel Marks, Joseph Geddes, Stephen Boppart

Proceedings Volume 6860, 68600Y (2008) https://doi.org/10.1117/12.763306

KEYWORDS: Raman spectroscopy, Interferometry, Signal detection, Tissues, Silicon, Silicates, Picosecond phenomena, Sodium, Laser beam diagnostics, CARS tomography

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Proceedings Article | 15 February 2008 Paper

Modeling and measurement of tissue elastic moduli using optical coherence elastography

Xing Liang, Amy Oldenburg, Vasilica Crecea, Sureshkumar Kalyanam, Michael Insana, Stephen Boppart

Proceedings Volume 6858, 685803 (2008) https://doi.org/10.1117/12.760779

KEYWORDS: Tissues, Tissue optics, Elastography, Optical coherence tomography, Silicon, Coherence (optics), Tumors, Soft tissue optics, Breast, 3D modeling

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Proceedings Article | 13 February 2008 Paper

Observation of the photoscattering effect from supercontinuum-generating germanosilicate fiber

Haohua Tu, Daniel Marks, Stephen Boppart

Proceedings Volume 6875, 68750Z (2008) https://doi.org/10.1117/12.763000

KEYWORDS: Waveguides, Light scattering, Silica, Glasses, Scattering, Fiber Bragg gratings, Absorption, Optical fibers, Spectroscopy, Laser damage threshold

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SPIE Journal Paper | 1 September 2007 Open Access

Optical coherence tomography: a review of clinical development from bench to bedside

Adam Zysk, Freddy Nguyen, Amy Oldenburg, Daniel Marks, Stephen Boppart

JBO, Vol. 12, Issue 05, 051403, (September 2007) https://doi.org/10.1117/12.10.1117/1.2793736

KEYWORDS: Optical coherence tomography, Tissues, Imaging systems, Tissue optics, Standards development, Biomedical optics, Visualization, In vivo imaging, Diagnostics, Tumors

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Proceedings Article | 15 February 2007 Paper

Real-time inverse scattering for optical coherence tomography

Tyler Ralston, Daniel Marks, P. Scott Carney, Stephen Boppart

Proceedings Volume 6446, 644608 (2007) https://doi.org/10.1117/12.699285

KEYWORDS: Optical coherence tomography, Inverse scattering, Fourier transforms, Scattering, Tissues, Real-time computing, Spatial frequencies, Gaussian beams, Quantum efficiency, Convolution

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Proceedings Article | 7 February 2007 Paper

High-numerical-aperture full-field optical coherence tomography with space-invariant resolution without scanning the focus

Daniel Marks, Tyler Ralston, P. Scott Carney, Stephen Boppart

Proceedings Volume 6429, 64291R (2007) https://doi.org/10.1117/12.703372

KEYWORDS: Optical coherence tomography, Telescopes, Fourier transforms, Beam splitters, Objectives, Inverse scattering, Signal detection, Diffraction, Image resolution, Data acquisition

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Proceedings Article | 7 February 2007 Paper

Backscattering albedo contrast in OCT using plasmon-resonant gold nanorods

Amy Oldenburg, Matthew Hansen, Alexander Wei, Stephen Boppart

Proceedings Volume 6429, 64291Z (2007) https://doi.org/10.1117/12.702847

KEYWORDS: Optical coherence tomography, Gold, Tissues, Backscatter, Scattering, Particles, Absorption, Tissue optics, Nanoparticles, Nanorods

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Proceedings Article | 7 February 2007 Paper

Phase-resolved spectral-domain magnetomotive optical coherence tomography

Vasilica Crecea, Amy Oldenburg, Tyler Ralston, Stephen Boppart

Proceedings Volume 6429, 64291X (2007) https://doi.org/10.1117/12.702649

KEYWORDS: Magnetism, Nanoparticles, Optical coherence tomography, Modulation, Tissues, Tissue optics, Phase shift keying, Data acquisition, Cameras, Light scattering

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Proceedings Article | 6 February 2007 Paper

Needle-probe system for the measurement of tissue refractive index

Adam Zysk, Steven Adie, Julian Armstrong, Matthew Leigh, Alexandre Paduch, Freddy Nguyen, David Sampson, Stephen Boppart

Proceedings Volume 6430, 64300O (2007) https://doi.org/10.1117/12.700955

KEYWORDS: Refractive index, Tissue optics, Tissues, Scattering, Optical coherence tomography, Interferometry, Channel projecting optics, Prototyping, Silicon, Interfaces

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Proceedings Article | 6 February 2007 Paper

Portable real-time optical coherence tomography system for intraoperative imaging and staging of breast cancer

Freddy Nguyen, Adam Zysk, Jan Kotynek, Frank Bellafiore, Kendrith Rowland, Patricia Johnson, J. Eric Chaney, Stephen Boppart

Proceedings Volume 6430, 64300H (2007) https://doi.org/10.1117/12.701128

KEYWORDS: Optical coherence tomography, Tissues, Tumors, Lymphatic system, Breast cancer, Cancer, Surgery, Imaging systems, Breast, Signal to noise ratio

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SPIE Journal Paper | 1 September 2006 Open Access

Computational methods for analysis of human breast tumor tissue in optical coherence tomography images

Adam Zysk, Stephen Boppart

JBO, Vol. 11, Issue 05, 054015, (September 2006) https://doi.org/10.1117/12.10.1117/1.2358964

KEYWORDS: Tissues, Tumors, Optical coherence tomography, Breast, Tissue optics, Biopsy, Scattering, Biological research, Signal attenuation, Computing systems

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SPIE Journal Paper | 1 May 2006 Open Access

High-resolution three-dimensional imaging of biofilm development using optical coherence tomography

Chuanwu Xi, Daniel Marks, Simon Schlachter, Wei Luo, Stephen Boppart

JBO, Vol. 11, Issue 03, 034001, (May 2006) https://doi.org/10.1117/12.10.1117/1.2209962

KEYWORDS: Optical coherence tomography, 3D image processing, Imaging systems, Visualization, Confocal microscopy, 3D image reconstruction, In vivo imaging, Microscopy, Scattering, Polymers

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SPIE Journal Paper | 1 March 2006 Open Access

Three-dimensional optical coherence tomography of the embryonic murine cardiovascular system

Wei Luo, Daniel Marks, Tyler Ralston, Stephen Boppart

JBO, Vol. 11, Issue 02, 021014, (March 2006) https://doi.org/10.1117/12.10.1117/1.2193465

KEYWORDS: Optical coherence tomography, 3D image processing, Heart, Tissue optics, Cardiovascular system, Visualization, Image resolution, Imaging systems, Tissues, 3D acquisition

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Proceedings Article | 20 February 2006 Paper

Light-scattering spectroscopic optical coherence tomography for differentiating cells in 3D cell culture

Chenyang Xu, P. Scott Carney, Wei Tan, Stephen Boppart

Proceedings Volume 6088, 608804 (2006) https://doi.org/10.1117/12.644415

KEYWORDS: Optical coherence tomography, Scattering, Light scattering, Spectroscopy, Polarization, Optical spheres, Modulation, Gaussian beams, Tissues, Optical spectroscopy

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Proceedings Article | 20 February 2006 Paper

Multi-modality imaging of structure and function combining spectral-domain optical coherence and multiphoton microscopy

Claudio Vinegoni, Tyler Ralston, Wei Tan, Wei Luo, Daniel Marks, Stephen Boppart

Proceedings Volume 6079, 60791D (2006) https://doi.org/10.1117/12.648745

KEYWORDS: Microscopes, Tissue optics, Multiphoton microscopy, Tissues, Imaging systems, Mirrors, Spectroscopy, Scattering, Photons, Signal detection

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Proceedings Article | 20 February 2006 Paper

Demonstration of inverse scattering in optical coherence tomography

Tyler Ralston, Dan Marks, P. Scott Carney, Stephen Boppart

Proceedings Volume 6079, 60791T (2006) https://doi.org/10.1117/12.648243

KEYWORDS: Optical coherence tomography, Confocal microscopy, Inverse scattering, Data modeling, Fourier transforms, Image resolution, Gaussian beams, Numerical simulations, Scattering, Data acquisition

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Proceedings Article | 20 February 2006 Paper

Detection of ultrastructural changes in genetically altered and exercised skeletal muscle using PS-OCT

James Pasquesi, Simon Schlachter, Marni Boppart, Eric Chaney, Stephen Kaufman, Stephen Boppart

Proceedings Volume 6079, 607926 (2006) https://doi.org/10.1117/12.646584

KEYWORDS: Birefringence, Polarization, Tissues, Optical fibers, Modulators, Proteins, Control systems, Luminescence, Electrodes, Optical coherence tomography

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Proceedings Article | 14 February 2006 Paper

High-resolution in vivo nanoparticle imaging using magnetomotive optical coherence tomography

Amy Oldenburg, Wei Luo, Stephen Boppart

Proceedings Volume 6097, 609702 (2006) https://doi.org/10.1117/12.643609

KEYWORDS: Particles, Magnetism, Optical coherence tomography, Nanoparticles, Tissues, Tissue optics, In vivo imaging, Scattering, Modulation, Signal detection

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Proceedings Article | 7 October 2005 Paper

Optical coherence tomography of cell dynamics in three-dimensional engineered tissues

Stephen Boppart, Wei Tan, Han-Jo Ko, Claudio Vinegoni

Proceedings Volume 5861, 58610Z (2005) https://doi.org/10.1117/12.632993

KEYWORDS: Tissues, Optical coherence tomography, Cell death, 3D image processing, Confocal microscopy, 3D modeling, Tissue optics, Microscopy, Imaging systems, Scattering

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SPIE Journal Paper | 1 July 2005 Open Access

Optical probes and techniques for molecular contrast enhancement in coherence imaging

Stephen Boppart, Amy Oldenburg, Chenyang Xu, Daniel Marks

JBO, Vol. 10, Issue 04, 041208, (July 2005) https://doi.org/10.1117/12.10.1117/1.2008974

KEYWORDS: Optical coherence tomography, Scattering, Tissue optics, Absorption, Tissues, Signal detection, Molecules, Biomedical optics, Nanoparticles, Molecular imaging

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Proceedings Article | 13 April 2005 Paper

Optical coherence elastography of developing biological tissues

Han-Jo Ko, Wei Tan, Ronald Stack, Stephen Boppart

Proceedings Volume 5690, (2005) https://doi.org/10.1117/12.592755

KEYWORDS: Tissues, Optical coherence tomography, Elastography, Tissue optics, Coherence (optics), Animal model studies, Image compression, Collagen, Biomedical optics, Scattering

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Proceedings Article | 13 April 2005 Paper

Molecularly sensitive optical ranging using nonlinear interferometric vibrational imaging

Daniel Marks, Claudio Vinegoni, Jeremy Bredfeldt, Stephen Boppart

Proceedings Volume 5690, (2005) https://doi.org/10.1117/12.592725

KEYWORDS: Optical coherence tomography, Ranging, Nonlinear optics, Interferometry, Beam splitters, Raman spectroscopy, Signal detection, Interfaces, CARS tomography, Raman scattering

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Proceedings Article | 13 April 2005 Paper

A least-square fitting algorithm for separating absorption and scattering profiles in spectroscopic optical coherence tomography

Chenyang Xu, Daniel Marks, Minh Do, Stephen Boppart

Proceedings Volume 5690, (2005) https://doi.org/10.1117/12.592568

KEYWORDS: Absorption, Scattering, Optical coherence tomography, Spectroscopy, Signal attenuation, Tissues, Signal to noise ratio, Time-frequency analysis, Monte Carlo methods, Optical spectroscopy

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Proceedings Article | 31 March 2005 Paper

Characterization of plasmon-resonant gold nanorods as near-infrared optical contrast agents investigated using a double-integrating sphere system

Amy Oldenburg, Daniel Zweifel, Chenyang Xu, Alexander Wei, Stephen Boppart

Proceedings Volume 5703, (2005) https://doi.org/10.1117/12.589617

KEYWORDS: Optical coherence tomography, Optical spheres, Scattering, Gold, Absorption, Light scattering, Imaging systems, Particles, Tissue optics, Nanorods

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Proceedings Article | 30 March 2005 Paper

Nonlinear interferometric vibrational imaging: optical ranging and spatial localization of CARS

Stephen Boppart, Daniel Marks, Jeremy Bredfeldt, Claudio Vinegoni

Proceedings Volume 5700, (2005) https://doi.org/10.1117/12.592862

KEYWORDS: Interferometry, Optical coherence tomography, Ranging, Molecules, Tissue optics, Tissues, Raman spectroscopy, Microscopy, Molecular imaging, Photons

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Proceedings Article | 29 March 2005 Paper

Optical coherence tomography of cell dynamics in three-dimensional engineered tissues

Wei Tan, Tejal Desai, Deborah Leckband, Stephen Boppart

Proceedings Volume 5699, (2005) https://doi.org/10.1117/12.590562

KEYWORDS: Tissues, Optical coherence tomography, Cell death, 3D image processing, 3D modeling, Imaging systems, Optical imaging, Tissue optics, Microscopes, Systems modeling

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Proceedings Article | 24 March 2005 Paper

Gaussian beam deconvolution in optical coherence tomography

Tyler Ralston, Daniel Marks, Farzad Kamalabadi, Stephen Boppart

Proceedings Volume 5701, (2005) https://doi.org/10.1117/12.590443

KEYWORDS: Optical coherence tomography, Gaussian beams, Confocal microscopy, Deconvolution, Reconstruction algorithms, Image resolution, Wavefronts, Spectral resolution, Signal analyzers, Signal to noise ratio

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SPIE Journal Paper | 1 November 2004 Open Access

Adaptive spectral apodization for sidelobe reduction in optical coherence tomography images

Daniel Marks, Paul Carney, Stephen Boppart

JBO, Vol. 9, Issue 06, (November 2004) https://doi.org/10.1117/12.10.1117/1.1806471

KEYWORDS: Optical coherence tomography, Signal to noise ratio, Optical filters, Filtering (signal processing), Optical fibers, Apodization, Digital filtering, Imaging systems, Scattering, Linear filtering

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SPIE Journal Paper | 1 November 2004 Open Access

Retinal response of Macaca mulatta to picosecond laser pulses of varying energy and spot size

William Roach, Clarence Cain, Drew Narayan, Gary Noojin, Stephen Boppart, Reginald Birngruber, James Fujimoto, Cynthia Toth

JBO, Vol. 9, Issue 06, (November 2004) https://doi.org/10.1117/12.10.1117/1.1805554

KEYWORDS: Optical coherence tomography, Reflectivity, Retina, Injuries, Laser induced breakdown spectroscopy, Picosecond phenomena, Tissues, Photomicroscopy, Eye, Laser energy

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Proceedings Article | 13 July 2004 Paper

Real-time digital design for an optical coherence tomography acquisition and processing system

Tyler Ralston, Jose Mayen, Dan Marks, Stephen Boppart

Proceedings Volume 5324, (2004) https://doi.org/10.1117/12.527829

KEYWORDS: Optical coherence tomography, Digital signal processing, Doppler effect, Data acquisition, Field programmable gate arrays, Optical filters, Spectroscopy, Finite impulse response filters, Demodulation, Doppler tomography

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Proceedings Article | 1 July 2004 Paper

Magnetic contrast agents for optical coherence tomography

Amy Oldenburg, Jillian Gunther, Farah Toublan, Daniel Marks, Kenneth Suslick, Stephen Boppart

Proceedings Volume 5316, (2004) https://doi.org/10.1117/12.529119

KEYWORDS: Magnetism, Optical coherence tomography, Particles, Tissues, Modulation, In vivo imaging, In vitro testing, Hematite, Scattering, Proteins

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Proceedings Article | 1 July 2004 Paper

Nonlinear interferometric vibrational imaging of molecular species

Jeremy Bredfeldt, Daniel Marks, Claudio Vinegoni, Selezion Hambir, Dana Dlott, Stephen Boppart

Proceedings Volume 5321, (2004) https://doi.org/10.1117/12.527834

KEYWORDS: Raman spectroscopy, Molecules, Interferometry, Spectroscopy, Optical coherence tomography, Polarization, Imaging spectroscopy, Optical spectroscopy, Nonlinear optics, Confocal microscopy

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Proceedings Article | 1 July 2004 Paper

Functional optical coherence tomography of stimulated and spontaneous scattering changes in neural tissue

Mariya Lazebnik, Daniel Marks, Kurt Potgieter, Rhanor Gillette, Stephen Boppart

Proceedings Volume 5316, (2004) https://doi.org/10.1117/12.530978

KEYWORDS: Optical coherence tomography, Tissue optics, Scattering, Optical fibers, Nerve, Temperature metrology, Light scattering, Ocean optics, Tissues, Laser scattering

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Proceedings Article | 1 July 2004 Paper

Structural and functional imaging of engineered tissue development using an integrated OCT and multiphoton microscope

Lester Fahrner, Wei Tan, Claudio Vinegoni, Thomas Eurell, Stephen Boppart

Proceedings Volume 5319, (2004) https://doi.org/10.1117/12.528328

KEYWORDS: Optical coherence tomography, Tissues, Microscopes, Confocal microscopy, Luminescence, Molecules, Objectives, Mirrors, Integration, Tissue engineering

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Proceedings Article | 23 December 2003 Paper

Imaging of mixing dynamics in micromixers using microscopy and optical coherence tomography

Chuanwu Xi, Dan Marks, Devang Parikh, Lutgarde Raskin, Stephen Boppart

Proceedings Volume 5345, (2003) https://doi.org/10.1117/12.523395

KEYWORDS: Optical coherence tomography, Microfluidics, Microscopy, 3D image processing, 3D image reconstruction, Image analysis, Confocal microscopy, Microfluidic imaging, Imaging systems, Scattering

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Proceedings Article | 12 September 2003 Paper

Optical characterization of contrast agents for optical coherence tomography

Tin-Man Lee, Farah Toublan, Amy Oldenburg, Shoeb Sitafalwalla, Wei Luo, Daniel Marks, Kenneth Suslick, Stephen Boppart

Proceedings Volume 4967, (2003) https://doi.org/10.1117/12.478396

KEYWORDS: Optical coherence tomography, Tissues, Scattering, Absorption, Gold, Carbon, Liver, Light scattering, Optical properties, Refractive index

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Proceedings Article | 8 July 2003 Paper

Molecular species-sensitive optical coherence tomography using coherent anti-stokes Raman scattering spectroscopy

Daniel Marks, Jeremy Bredfeldt, Selezion Hambir, Dana Dlott, Barbara Kitchell, Martin Gruebele, Stephen Boppart

Proceedings Volume 4956, (2003) https://doi.org/10.1117/12.477787

KEYWORDS: Optical coherence tomography, Molecules, Interferometry, Tissues, Signal detection, CARS tomography, Nonlinear optics, Raman spectroscopy, Molecular spectroscopy, Optical amplifiers

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Proceedings Article | 8 July 2003 Paper

Distortion corrected imaging using projected index computed tomography

Adam Zysk, James Reynolds, Daniel Marks, P. Scott Carney, Stephen Boppart

Proceedings Volume 4956, (2003) https://doi.org/10.1117/12.479031

KEYWORDS: Optical coherence tomography, Distortion, Refraction, Computed tomography, Tomography, Reflectivity, Natural surfaces, Optical testing, CT reconstruction, Refractive index

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Proceedings Article | 19 June 2003 Paper

Optical manipulation of silicon microparticles in biological environments

Amy Oldenburg, Se-Jung Moon, Karthy Kasi, Taekyung Kim, Chuen Ho, Rolf Timp, Hyungsoo Choi, Vladimir Gelfand, Joseph Roland, Kyekyoon Kim, Stephen Boppart, Gregory Timp

Proceedings Volume 4962, (2003) https://doi.org/10.1117/12.478123

KEYWORDS: Particles, Silicon, Optical tweezers, Bragg cells, Optical spheres, Objectives, Polymethylmethacrylate, Microscopes, Optical manipulation, Latex

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Proceedings Article | 17 January 2003 Paper

Use of molecular beacons for the detection of bacteria in microfluidic devices

Chuanwu Xi, Stephen Boppart, Lutgarde Raskin

Proceedings Volume 4982, (2003) https://doi.org/10.1117/12.478143

KEYWORDS: Microfluidics, Luminescence, Oxygen, Confocal microscopy, Biosensors, Plasma, Bacteria, Diamond, BioMEMS, Pathogens

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SPIE Journal Paper | 1 October 1999 Open Access

Comparison of optical coherence tomography imaging of cataracts with histopathology

Cheryl DiCarlo, William Roach, Donald Gagliano, Stephen Boppart, Daniel Hammer, Ann Cox, James Fujimoto

JBO, Vol. 4, Issue 04, (October 1999) https://doi.org/10.1117/12.10.1117/1.429951

KEYWORDS: Optical coherence tomography, Photomicroscopy, Opacity, Reflectivity, Eye, Lab on a chip, Tissues, Coherence imaging, Photography, Lenses

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Proceedings Article | 9 July 1999 Paper

Endoscopic optical coherence tomography imaging for surgical diagnostics and guidance in the gastrointestinal tract

Stephen Boppart, Xing Li, Constantinos Pitris, Debra Stamper, Mark Brezinski, James Fujimoto

Proceedings Volume 3595, (1999) https://doi.org/10.1117/12.351529

KEYWORDS: Optical coherence tomography, Tissue optics, In vivo imaging, Imaging systems, Tissues, Image resolution, Esophagus, Endoscopy, Diagnostics, Ultrasonography

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Proceedings Article | 22 June 1999 Paper

High-resolution in-vivo intra-arterial imaging with optical coherence tomography

Stephen Boppart, Constantinos Pitris, Ravi Ghanta, Xing Li, Wolfgang Drexler, James Fujimoto, Mark Brezinski

Proceedings Volume 3590, (1999) https://doi.org/10.1117/12.350978

KEYWORDS: Optical coherence tomography, Image resolution, In vivo imaging, Imaging systems, Blood, Coherence imaging, Tissue optics, Optical imaging, Image acquisition, In vitro testing

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Proceedings Article | 30 April 1999 Paper

Subcellular optical coherence tomography with a Kerr lens mode-locked Ti:Al2O3 laser

Wolfgang Drexler, Uwe Morgner, Constantinos Pitris, Stephen Boppart, Franz Kaertner, Xing Li, Seong-Ho Cho, Erich Ippen, Mark Brezinski, James Fujimoto

Proceedings Volume 3598, (1999) https://doi.org/10.1117/12.347502

KEYWORDS: Optical coherence tomography, Image resolution, Mode locking, In vivo imaging, Imaging systems, Light sources, Tissues, Spectroscopy, Scattering, Mirrors

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Proceedings Article | 30 April 1999 Paper

High-resolution imaging of neoplastic lesions using optical coherence tomography

Constantinos Pitris, Annekathryn Goodman, Stephen Boppart, Wolfgang Drexler, Christine Jesser, Debra Stamper, Mark Brezinski, James Fujimoto

Proceedings Volume 3598, (1999) https://doi.org/10.1117/12.347476

KEYWORDS: Optical coherence tomography, Tissue optics, Image resolution, Tissues, Cancer, Endoscopes, Imaging technologies, Ultrasonography, Imaging systems, In vivo imaging

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Proceedings Article | 18 August 1997 Paper

Endoscopic optical coherence tomography

Guillermo Tearney, Brett Bouma, Mark Brezinski, Stephen Boppart, Constantinos Pitris, James Southern, Eric Swanson, James Fujimoto

Proceedings Volume 2979, (1997) https://doi.org/10.1117/12.280212

KEYWORDS: Optical coherence tomography, Endoscopy, Imaging systems, Image resolution, In vivo imaging, Tissues, Coherence (optics), Image acquisition, Tissue optics, Optical imaging

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Proceedings Article | 16 June 1997 Paper

Optical coherence tomography of the retinal response to ultrashort laser pulses

Cynthia Toth, Drew Narayan, William Roach, Reginald Birngruber, Stephen Boppart, Michael Hee, Cheryl DiCarlo, Clarence Cain, Gary Noojin, James Fujimoto

Proceedings Volume 2975, (1997) https://doi.org/10.1117/12.275466

KEYWORDS: Optical coherence tomography, Reflectivity, Injuries, Retina, Ultrafast phenomena, Picosecond phenomena, Tissue optics, Laser tissue interaction, Pulsed laser operation, In vivo imaging

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Proceedings Article | 22 May 1997 Paper

Mode-locked solid state laser sources for optical coherence tomography

Brett Bouma, Guillermo Tearney, Stephen Boppart, Boris Golubovic, Igor Bilinsky, Mark Brezinski, James Fujimoto

Proceedings Volume 2981, (1997) https://doi.org/10.1117/12.274320

KEYWORDS: Optical coherence tomography, Tissue optics, Image resolution, Mode locking, Coherence (optics), Tissues, Modulation, Solid state lasers, Tomography, Laser sources

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Proceedings Article | 22 May 1995 Paper

In vivo imaging of the development of linear and nonlinear retinal laser effects using optical coherence tomography in correlation with histopathological findings

Reginald Birngruber, Michael Hee, Stephen Boppart, James Fujimoto, Eric Swanson, Cynthia Toth, Cheryl DiCarlo, Clarence Cain, Gary Noojin, William Roach

Proceedings Volume 2391, (1995) https://doi.org/10.1117/12.209892

KEYWORDS: Optical coherence tomography, Retina, Eye, In vivo imaging, Argon ion lasers, Nonlinear optics, Laser optics, Tissues, Image resolution, Injuries

Read Abstract +

Optical Coherence Tomography (OCT) is a new, non-invasive diagnostic technique for high resolution optical 3D imaging, which was developed and applied to several different biological materials during the lasi; five years [1, 2, 3]. A unique application ofthis technique is the microscopical cross-sectional imaging ofpostenor structures ofthe eye which are not accessable with other high resolution techniques in-vivo neither with x-ray-imaging nor with high frequency ultrasound scanning. The superior spatial resolution on the order ofabout lOtm laterally and axially, the high signal-to-noise ratio ofmore than 100 db and the fast acquisition-time of one second for a two dimensional scan provides a technique for cross-sectional in-vivo-momtoring ofintraocular structures and therefore the possibility to study the time course of anatomical and pathological developments in the eye. The acute morphological changes of ocular structures and their biological healing response after shortterm impacts such as high-intensity laser exposures are ofparticular interest for the understanding of the mechanisms responsible for therapeutic laser-application in ophthal-mology as well as for laser injury to the eye. A correlation between cross-sectional OCT-images and structural findings using classical histopathological techniques facilitates a better interpretation ofthe characteristic patterns seen in OCTimages and defines the sensitivity ofthe OCT-technique to image morphological details. On the other hand preparational artefacts not avoidable in all histological procedures can be identified and analyzed by comparing histological micrographs with OCT-images of exactly the same structure. First results of an experimental study where retinal effects were produced in monkey eyes using laser pulses from 200 ms to 130 fs in duration are presented in this article. The applied energies from 5tJ to 50 mJ were able to induce the whole spectrum of biological effects possible in the eye, ranging from intraretinal microruptures to extensive thermal denaturation and massive preretinal hemorrhages [4, 5, 6].

Proceedings Article | 22 May 1995 Paper

First-order model for computation of laser-induced breakdown thresholds in condensed media

Paul Kennedy, Stephen Boppart, Daniel Hammer, Benjamin Rockwell, Gary Noojin, William Roach

Proceedings Volume 2391, (1995) https://doi.org/10.1117/12.209922

KEYWORDS: Ionization, Electrons, Eye models, Laser induced breakdown spectroscopy, Solid modeling, Laser damage threshold, Plasma, Laser induced damage, Liquids, Polonium

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Proceedings Article | 12 May 1995 Paper

New noninvasive imaging technique for cataract evaluation in the rhesus monkey

Cheryl DiCarlo, Stephen Boppart, Donald Gagliano, Rodney Amnotte, Audrey Smith, Daniel Hammer, Ann Cox, Michael Hee, James Fujimoto, Eric Swanson, William Roach

Proceedings Volume 2395, (1995) https://doi.org/10.1117/12.209062

KEYWORDS: Optical coherence tomography, Opacity, Lab on a chip, Reflectivity, Eye, Photography, Lamps, In vivo imaging, Tissue optics, Tissues

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Proceedings Article | 17 August 1994 Paper

Femtosecond laser threshold: retinal damage versus induced breakdown mechanisms

Clarence Cain, Cynthia Toth, Cindy Stein, Gary Noojin, David Stolarski, Benjamin Rockwell, Stephen Boppart, William Roach

Proceedings Volume 2134, (1994) https://doi.org/10.1117/12.182940

KEYWORDS: Eye, Femtosecond phenomena, Laser damage threshold, Laser induced breakdown spectroscopy, Vitreous, Water, Laser induced damage

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Proceedings Article | 17 August 1994 Paper

Temperature dependence of laser-induced breakdown

Daniel Hammer, Rex Eiserer, Gary Noojin, Stephen Boppart, Paul Kennedy, William Roach

Proceedings Volume 2134, (1994) https://doi.org/10.1117/12.182956

KEYWORDS: Laser induced breakdown spectroscopy, Laser induced damage, Laser optics, Picosecond phenomena, Eye, Temperature metrology, Femtosecond phenomena, Visible radiation, Near infrared, Vitreous

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Proceedings Article | 7 July 1993 Paper

Shielding effectiveness of femtosecond laser-induced plasmas in ultrapure water

Stephen Boppart, C. Toth, William Roach, Benjamin Rockwell

Proceedings Volume 1882, (1993) https://doi.org/10.1117/12.147675

KEYWORDS: Laser induced breakdown spectroscopy, Plasmas, Pulsed laser operation, Picosecond phenomena, Femtosecond phenomena, Retina, Eye, Laser tissue interaction, Amplifiers, Sensors

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Showing 5 of 199 publications

Proceedings Volume Editor (2)

SPIE Conference Volume | 4 October 2019

Optical Coherence Imaging Techniques and Imaging in Scattering Media III

SPIE Conference Volume | 3 October 2017

Optical Coherence Imaging Techniques and Imaging in Scattering Media II

Conference Committee Involvement (77)

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIX

27 January 2025 | San Francisco, California, United States

Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XXIII

27 January 2025 | San Francisco, California, United States

Advanced Chemical Microscopy for Life Science and Translational Medicine 2025

25 January 2025 | San Francisco, California, United States

Biomedical Light Scattering XV

25 January 2025 | San Francisco, California, United States

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII

29 January 2024 | San Francisco, California, United States

Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XXII

29 January 2024 | San Francisco, California, United States

Advanced Chemical Microscopy for Life Science and Translational Medicine 2024

27 January 2024 | San Francisco, California, United States

Biomedical Applications of Light Scattering XIV

27 January 2024 | San Francisco, California, United States

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII

30 January 2023 | San Francisco, California, United States

Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XXI

30 January 2023 | San Francisco, California, United States

Advanced Chemical Microscopy for Life Science and Translational Medicine 2023

28 January 2023 | San Francisco, California, United States

Biomedical Applications of Light Scattering XIII

28 January 2023 | San Francisco, California, United States

Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XX

24 January 2022 | San Francisco, California, United States

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI

24 January 2022 | San Francisco, California, United States

Advanced Chemical Microscopy for Life Science and Translational Medicine 2022

23 January 2022 | San Francisco, California, United States

Biomedical Applications of Light Scattering XII

22 January 2022 | San Francisco, California, United States

Advanced Chemical Microscopy for Life Science and Translational Medicine 2021

6 March 2021 | Online Only, California, United States

Biomedical Applications of Light Scattering XI

6 March 2021 | Online Only, California, United States

Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XIX

6 March 2021 | Online Only, California, United States

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV

6 March 2021 | Online Only, California, United States

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV

3 February 2020 | San Francisco, California, United States

Advanced Chemical Microscopy for Life Science and Translational Medicine

1 February 2020 | San Francisco, California, United States

Biomedical Applications of Light Scattering X

1 February 2020 | San Francisco, California, United States

Optics in Health Care and Biomedical Optics IX

21 October 2019 | Hangzhou, China

Optical Coherence Imaging Techniques and Imaging in Scattering Media

25 June 2019 | Munich, Germany

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIII

4 February 2019 | San Francisco, California, United States

Optical Elastography and Tissue Biomechanics VI

2 February 2019 | San Francisco, California, United States

Optics in Health Care and Biomedical Optics VIII

11 October 2018 | Beijing, China

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII

29 January 2018 | San Francisco, California, United States

Optical Elastography and Tissue Biomechanics V

27 January 2018 | San Francisco, California, United States

Optical Coherence Imaging Techniques and Imaging in Scattering Media II

25 June 2017 | Munich, Germany

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI

30 January 2017 | San Francisco, California, United States

Optical Elastography and Tissue Biomechanics IV

28 January 2017 | San Francisco, California, United States

Optics in Health Care and Biomedical Optics VII

12 October 2016 | Beijing, China

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX

15 February 2016 | San Francisco, California, United States

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIV

14 February 2016 | San Francisco, California, United States

Optical Elastography and Tissue Biomechanics III

13 February 2016 | San Francisco, California, United States

Optical Coherence Imaging Techniques and Imaging in Scattering Media

21 June 2015 | Munich, Germany

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX

9 February 2015 | San Francisco, California, United States

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII

8 February 2015 | San Francisco, California, United States

Biomedical Applications of Light Scattering IX

7 February 2015 | San Francisco, California, United States

Optical Elastography and Tissue Biomechanics II

7 February 2015 | San Francisco, California, United States

Optics in Health Care and Biomedical Optics VI

9 October 2014 | Beijing, China

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII

3 February 2014 | San Francisco, California, United States

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XII

2 February 2014 | San Francisco, California, United States

Biomedical Applications of Light Scattering VIII

1 February 2014 | San Francisco, California, United States

Optical Elastography and Tissue Biomechanics

1 February 2014 | San Francisco, California, United States

Optical Coherence Tomography and Coherence Techniques VI

13 May 2013 | Munich, Germany

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII

4 February 2013 | San Francisco, California, United States

Biomedical Applications of Light Scattering VII

2 February 2013 | San Francisco, California, United States

Optics in Health Care and Biomedical Optics V

5 November 2012 | Beijing, China

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI

23 January 2012 | San Francisco, California, United States

Advanced Biomedical and Clinical Diagnostic Systems X

22 January 2012 | San Francisco, California, United States

Biomedical Applications of Light Scattering VI

21 January 2012 | San Francisco, California, United States

Optical Coherence Tomography and Coherence Techniques V

24 May 2011 | Munich, Germany

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV

24 January 2011 | San Francisco, California, United States

Optical Interactions with Tissue and Cells XXII

24 January 2011 | San Francisco, California, United States

Advanced Biomedical and Clinical Diagnostic Systems IX

23 January 2011 | San Francisco, California, United States

Biomedical Applications of Light Scattering V

22 January 2011 | San Francisco, California, United States

Optics in Health Care and Biomedical Optics IV

18 October 2010 | Beijing, China

Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XIV

25 January 2010 | San Francisco, California, United States

Advanced Biomedical and Clinical Diagnostic Systems VIII

24 January 2010 | San Francisco, California, United States

Optics in Tissue Engineering and Regenerative Medicine IV

24 January 2010 | San Francisco, California, United States

Biomedical Applications of Light Scattering IV

23 January 2010 | San Francisco, California, United States

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIII

26 January 2009 | San Jose, California, United States

Biomedical Applications of Light Scattering III

24 January 2009 | San Jose, California, United States

Optics in Tissue Engineering and Regenerative Medicine III

24 January 2009 | San Jose, California, United States

Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII

21 January 2008 | San Jose, California, United States

Optics in Tissue Engineering and Regenerative Medicine II

20 January 2008 | San Jose, California, United States

Biomedical Applications of Light Scattering II

19 January 2008 | San Jose, California, United States

Optical Coherence Tomography and Coherence Techniques

17 June 2007 | Munich, Germany

Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI

22 January 2007 | San Jose, California, United States

Optics in Tissue Engineering & Regenerative Medicine

21 January 2007 | San Jose, California, United States

Biomedical Applications of Light Scattering

20 January 2007 | San Jose, California, United States

Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X

23 January 2006 | San Jose, California, United States

Optical Coherence Tomography and Coherence Techniques II

12 June 2005 | Munich, Germany

Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX

23 January 2005 | San Jose, CA, United States

Showing 5 of 77 Conference Committees

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