Multimodal measurements of brain tissue metabolism and perfusion in a neonatal model of hypoxic-ischaemic injury

Gemma Bale; Ajay Rajaram; Matthew Kewin; Laura Morrison; Alan Bainbridge; Linshan Liu; Udunna Anazodo; Mamadou Diop; Keith St. Lawrence; Ilias Tachtsidis

doi:10.1117/12.2526729

11 July 2019 Multimodal measurements of brain tissue metabolism and perfusion in a neonatal model of hypoxic-ischaemic injury

Gemma Bale, Ajay Rajaram, Matthew Kewin, Laura Morrison, Alan Bainbridge, Linshan Liu, Udunna Anazodo, Mamadou Diop, Keith St. Lawrence, Ilias Tachtsidis

Author Affiliations +

Proceedings Volume 11074, Diffuse Optical Spectroscopy and Imaging VII; 1107414 (2019) https://doi.org/10.1117/12.2526729
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

This is the first multimodal study of cerebral tissue metabolism and perfusion post-hypoxic-ischaemic (HI) brain injury with broadband near-infrared spectroscopy (bNIRS), diffuse correlation spectroscopy (DCS), positron emission tomography (PET) and magnetic resonance spectroscopy (MRS). In 5 piglet models of HI, we measured cerebral tissue saturation (StO₂), cerebral blood flow (CBF), cerebral oxygen metabolism (CMRO₂), changes in the mitochondrial oxidation state of cytochrome-c-oxidase (oxCCO), cerebral glucose metabolism (CMRglc), and tissue biochemistry (Lac+Thr/tNAA). At baseline, the parameters measured were: 64±6 % StO₂, 35±11 ml/100g/min CBF, and 2.0±0.4 μmol/100g/min CMRO₂. After HI the parameters measured were: 68±6% StO₂, 35±6 ml/100g/min CBF, 1.3±0.1 μmol/100g/min CMRO₂, 0.4±0.2 Lac+Thr/tNAA, and 9.5±2.0 CMRglc. This study demonstrates the capacity of a multimodal set up to interrogate the pathophysiology of HIE using a combination of optical methods, MRS, and PET.

Citation Download Citation

Gemma Bale, Ajay Rajaram, Matthew Kewin, Laura Morrison, Alan Bainbridge, Linshan Liu, Udunna Anazodo, Mamadou Diop, Keith St. Lawrence, and Ilias Tachtsidis "Multimodal measurements of brain tissue metabolism and perfusion in a neonatal model of hypoxic-ischaemic injury", Proc. SPIE 11074, Diffuse Optical Spectroscopy and Imaging VII, 1107414 (11 July 2019); https://doi.org/10.1117/12.2526729

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